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Abamax (Amitriptyline)

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Abamax is used to treat depression. Compared to other antidepressants, it has a higher risk of side effects, such as weight gain and drowsiness. Abamax is a tricyclic antidepressant (TCA). It works on parts of the brain responsible for raising levels of certain chemicals, like serotonin and norepinephrine, to help improve your mood.

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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Abamax dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Abamax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Abamax if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Abamax if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Abamax is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Abamax is not approved for use by anyone younger than 12 years old.

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Elevated ceramide levels in GH4C1 cells treated with retinoic acid. Using cytochrome c oxidase, succinate dehydrogenase, acid phosphatase and NADPH-cytochrome c reductase as marker enzymes, poly(A) hydrolase has been shown to be a mitochondrial enzyme. The data suggest that THC acts to induce sympathetic stimulation and parasympathetic inhibition of cardiovascular control pathways. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. Eight children with histiocytosis X were investigated with reference to immunologic reactivity in vitro (PHA, PWM, Con-A and MLC testing).

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Comparison of nuclear magnetic resonance and histology in necrosis of the femoral head. Modulation of cytokine production from an EpiOcular corneal cell culture model in response to Staphylococcus aureus superantigen. Over the entire dose range tested, little, if any, sensitivity difference between the host and the prophage was found at the end of cell division delay. Between 1973 and 1984, five patients underwent excision of a carotid body tumor without operative mortality, cranial nerve palsy, cerebrovascular accident, or recurrence when followed to the present or to death from unassociated causes. Only the overall extension of the neurite appears to be inhibited. The number of chemosensitive TBCs was much larger than the number of innervated TBCs in a taste bud, indicating the existence of chemosensitivity in non-innervated TBCs.

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In the present study, close ophthalmologic examinations were performed on 11 patients with FCMD, and we found myopia, weakness of the orbicularis oculi, congenital nystagmus, cortical blindness, optic atrophy, chorioretinal degeneration, etc. Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53. Cephalometric technics of assessing the rhinopharyngeal functional area and adenoid tissue. Related effects of copper, zinc and iron on performance, hematology and copper stores of pigs. Eleven of the 139 patients were studied for antibody to lymphocytic choriomeningitis (LCM) virus. Transmission electron microscopy revealed that the tissue cyst wall was composed of granular material and was directly beneath the parasitophorous vacuole membrane. Implosive therapy and desensitization therapy using free association in the treatment of inpatients. Uptake of polyvinyl alcohol by macrophages in the glomerular mesangium of rats. Uroguanylin and guanylin, endogenous ligands of the guanylate cyclase C receptor, are presumed to mediate fluid and electrolyte secretion in the intestine. Three had minimal x-ray degenerative changes, which did not result in increased pain or in loss of motion and grip strength.

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The results obtained in a group of rats treated with allantoin were compared with those obtained in a control group of rats. This article presents a further description on the background, significance, and structure characteristics of Quantitative Medicine Simulation and Operation by Computer (QMSOC). T cell and non-T cell in joint fluid were obtained from patients with RA (19) and osteoarthritis (OA (9)). Left heart volume characteristics with a right ventricular volume overload. Twelve patients received a propofol bolus (1 mg/kg) followed by an infusion of 3 mg/kg/hr. LAD-1 is absent in a subset of junctional epidermolysis bullosa patients. Immunological relationships among antihemorrhagic factors (AHF) present in the plasma of different snakes and a mammal (opossum) were studied. In these cloned cultures, virus growth was not detectable upon infection with SV40, while a small amount of virus was produced upon infection with polyoma virus.

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Clinical study on splenic autotransplantation after splenectomy in idiopathic thrombocytopenic purpura. Clinical importance of the interaction of phenytoin and isoniazid: a report from the Boston Collaborative Drug Surveillance Program. Epidemiology of fetal alcohol syndrome among American Indians of the Southwest. As expected, primary tumor size, grade, and the presence of peritumoral vascular invasion are the most important prognostic factors. None of these hormones suppressed the cytotoxic activity of previously sensitized effector cells generated in vitro. To replenish this deficiency, the adenosine deaminase level was studied in 12 rat tissues at experimental crush syndrome in vivo. These measurements allow clear appreciation of the marked difference between the mechanical and chemico-physical properties at the aqueous interface of the uncoated and hyaluronan-coated lenses.

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Revised distribution parameters for serum markers for trisomy 18. The pharmacokinetics and effects of prochlorperazine in elderly female volunteers. A number of inhibitors of glycolysis and uncouplers of oxidative phosphorylation have been shown to increase the leakage of intracellular enzymes from preparations of rat lymphocytes and human lymphocytes and erythrocytes. Each subject was asked to stare at a simple picture of a facial expression (crying or smiling faces) during the auditory and visual oddball tasks. The mAb did not react with rOvIL-1 alpha, IL-2, IL-4, IL-8, tumor necrosis factor-alpha, gamma-interferon or recombinant human IL-1 beta in indirect EIA. Delayed cutaneous hypersensitivity in normals: choice of antigens and comparison to in vitro assays of cell-mediated immunity. Western blot and immunohistochemical analyses were carried out by using a monoclonal antibody (D3) directed against an epitope of the intracellular domain specific to NCAM 180 and antibodies against all NCAM isoforms. pombe telomere sequence, suggesting that the ability to improve the segregation of ARS plasmids is a general property of telomere repeats.

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With current technological advances, it is now possible to measure in less than 50 microL of plasma picomolar amounts of circulating products of platelet activation, products of protease activation related to coagulation and fibrinolytic pathways, and prostaglandin metabolites formed during a physiologic or pathologic process. Vaccinator device for delivering propellant-driven aerosols of Streptococcus suis bacterin into the respiratory tracts of swine. Hourly examinations were made, and after 6 hours the cups were removed and gingival mucosa scored for irritation by a previously described method. The evidence suggests that MAO evokes a reflex sympathetic discharge which is subject to override by the carotid sinus depressor reflex. Results of cystometry and urethral pressure profilometry in dogs sedated with medetomidine or xylazine. Expression of a functional asialoglycoprotein receptor through transfection of a cloned cDNA that encodes a macrophage lectin. AIDS has modified the clinical and evolutive forms of the disease. Clinical relevance of acetabular erosion in young patients with a bipolar hip prosthesis. Conventional electron microscopy and high-resolution immunocytochemistry revealed a high degree of structural preservation, a condition in which inorganic elements are expected to can i take 20 mg of claritin maintain their native distribution.

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We present the results from three surveys conducted in 1988, 1991 and 1994 in Hedmark comparing risk factors for cardiovascular disease among men and women age 40-42 years. The gene encoding a novel milk protein-hydrolyzing proteinase was cloned on a 6.56-kb SstI fragment from Streptomyces sp. Contrast mometasone nasal dose material (Renografin 76) caused systemic hypotension, rise in left ventricular diastolic pressure and decreases in LV dp/dt and dp/dt/LVP in both states. Interleukin-2 and alpha interferon therapy of advanced pulmonary metastases. Aminoacyl-tRNA-synthetases were only slightly inactivated under comparable conditions. When undertaken by skilled laparoscopic surgeon, it carries low mortality and morbidity. It was stated that Polish ships were properly equipped and well prepared to comply with the obligations provided by international conventions. We examined whether starvation affected the amount of EF-2 protein as well as the level of its mRNA in the liver and skeletal muscle of mice, to understand the molecular mechanism for nutritional adaptation of protein-turnover. The hormonal condition permitting delayed nidation in rats ovarectomized on day 4 or 5 of pregnancy was studied by administering progesterone and estradiol in differents sequences between days 9 and 14. coli strains infecting the urinary tract, however, the evidence for the expression of these fimbriae in situ has been implied rather than proven.

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Features of the clinical course of burn shock in irradiation of the organism by ionizing radiations. Evaluation of clinical parameters in protonix medication dosage the assessment of disability in hypertension. The results of direct pressure measurement in pulmonary circulation in 452 patients with ventricular septal defect (216 males and 236 females), whose age ranged from 12 months to 37 years, were analysed. Computed tomography imaging with reconstruction identifies acetabular anatomy most clearly and allows precise measurements to be made. Two plant-type ferredoxins were isolated and purified from a blue-green alga, Nostoc verrucosum. We suggest practical strategies for detecting optimal sleep stages.

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