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Abamune (Lamivudine)
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Abamune

Abamune is a first-choice HIV antiretroviral (ARV) used in combination with other HIV ARVs for the treatment of HIV. It can also be used for the treatment of hepatitis B, but it's not a first-choice option.

Other names for this medication:
Abamune, Combivir, Duovir, Emduo, Emtri, Haptavir, Hepavud, Hepitec, Hepravir, Hivir, Ladiwin, Lamidac, Lamivir, Lamivox, Lamivudine, Lamostad, Lamuvid, Lavir, Lazid, Lmivir, Odivir, Retrolam, Shanvudin, Stadin, Stavex, Tenola, Tenolam, Tenvir, Trimune, Trioday, Viramid, Virolam, Virolis

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Also known as: Lamivudine

Description

Abamune is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Abamune is not a cure for HIV or AIDS. Abamune is used to treat chronic hepatitis B. Abamune works by blocking the ability of the hepatitis B virus to multiply and infect new liver cells. Abamune is also known as Lamivudine, Lamivir, Zeffix, Heptovir. Generic Name of Abamune is Lamivudine. Brand names of Abamune are Abamune, Abamune HBR.

Dosage

This section provides information on the proper use of a number of products that contain lamivudine. It may not be specific to Abamune A/F. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Abamune® and Abamune-HBV® both contain the same medicine, but Abamune® has more medicine in each tablet or dose of liquid. Use only the brand of this medicine that your doctor prescribed. If you have HIV or AIDS, you need to use Abamune®. If you have hepatitis B but you do not have HIV or AIDS, you can use Abamune-HBV®.

Your doctor may want to test you for HIV before you start using Abamune-HBV® and during your treatment. Your medicine may need to be changed based on these test results.

It is important to take Abamune® as part of a combination regimen. Take all of the medicines your doctor prescribed at the right time of day. This will make your medicines work better.

Keep using lamivudine for the full time of treatment, even if you or your child begin to feel better. Do not stop using it without checking first with your doctor. When your supply of the medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of the medicine.

If you are using the oral liquid, use a specially marked measuring spoon, dosing syringe, or medicine cup to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (solution or tablets): For treatment of hepatitis B infection: Adults—100 milligrams (mg) once a day. Children 2 to 17 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 3 milligrams (mg) per kilogram (kg) of body weight per day. The doctor may increase your dose as needed. However, the dose is usually not more than 100 mg per day. If your child cannot swallow the tablets, he or she may take the oral liquid. Children younger than 2 years of age—Use and dose must be determined by your doctor. For treatment of HIV infection or AIDS: Adults—300 milligrams (mg) once a day or 150 mg 2 times a day. Children 3 months of age and older— Solution: Dose is based on body weight and must be determined by your doctor. The dose is usually 5 milligrams (mg) per kilogram (kg) of body weight taken 2 times a day, or 10 mg per kg once a day. The doctor may increase your dose as needed. However, the dose is usually not more than 300 mg per day, taken with other HIV medicines. Tablets: Dose is based on body weight and must be determined by your doctor. The dose is usually 150 to 300 mg per day. If your child weighs 14 kg or more, it is preferred that he or she take the scored tablet. Children younger than 3 months of age—Use and dose must be determined by your doctor.

Note: Patients that require treatment for both hepatitis B and either AIDS or HIV should follow the dosing schedule for HIV or AIDS.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Lamivudine dosage information

Side effects

The most common side effects associated with Abamune are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Abamune if you are allergic to lamivudine.

You should not take Abamune-HBV (for treating hepatitis B) if you also take other medicine that contains lamivudine or emtricitabine, which includes Atripla, Biktarvy, Cimduo, Combivir, Complera, Descovy, Emtriva, Epzicom, Genvoya, Odefsey, Stribild, Symfi, Triumeq, Trizivir, and Truvada.

Tell your doctor if you have ever had:

liver disease (especially hepatitis B or C, or a liver transplant); pancreatitis; kidney disease; or diabetes (liquid lamivudine contains 3 to 4 grams of sucrose per dose).

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

You should not breast-feed while you are using lamivudine to treat hepatitis B. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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Rotaviruses have a wide host range infecting a broad range of animal species, however little is known about rotavirus infection in exotic animals. Screening tools available today are effective for several types of dementia. The model can rationalize the various experimental observations including the potency of the truncated GIP peptide. Different behavioral profiles emerged for men and women identified as hazardous drinkers on the AUDIT. Because of the variable results presented in mainly retrospective reports, it has been queried whether local control can be as good with conventional surgery as with micrographic surgery. This would be equally beneficial for improvement of soil nitrogen status. The feasibility of establishing a programme of adjuvant autologous vaccination for renal cell carcinoma. These data were used to propose a mechanism for BAG-1 in the regulation of Hsp70/Hsc70 chaperone activity.

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Previous research on the effects of intracranial stents on arterial hemodynamics has involved computational hemodynamics (CHD) simulations applied to artificially generated stent models. The patient died from complications of acute pancreatitis 3 years after the last operation, without overt clinical signs of cancer recurrence. The medical diflucan medication files of 216 twin pregnancies (group 1) conceived through IVF/ICSI and 377 spontaneously conceived twin pregnancies (group 2) were assessed retrospectively. Based on data from mutant studies, transgenic analysis and gene ontology (GO) annotation, we have identified a total of 1026 genes in the Arabidopsis genome that participate in plant hormone functions. Tamoxifen and raloxifene are both indicated for and equally effective in the prevention of breast cancer in women at high risk for development of the disease. In accordance with the German law on care for helpless persons, an observer rating scale has been developed to allow a staging of need of care. The aim of our study was to investigate the potency of silymarin, the polyphenol fraction from the seeds of Silybum marianum, to modulate UVA-induced oxidative damage to human keratinocytes.

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Studies were identified from a MEDLINE search through 31 May 2006 and from the reference lists of identified publications. A single dose zoledronic acid enhances pin fixation in high tibial osteotomy using the hemicallotasis technique. It also decreased IGF1-induced protein synthesis and phosphorylation of P70S6 kinase and ribosomal S6 protein. If proven safe and efficacious, ferric citrate will likely provide an additional phosphate binder to treat chronic kidney disease associated mineral and bone disorders. In the process the limitations of the interpreter and how the presence of the interpreter can be facilitated, is also highlighted. Gender, body mass index, smoking status, disease duration, extraintestinal manifestation, length of bowel resected, total number of nodes examined, medical treatment, and indications for surgery were not significantly different between the groups. Analysis of genotype frequencies and interlocus association for the PM, DQA1, and D1S80 loci in four populations. Notably, the regional and temporal dependence of diffusion anisotropy and folding were distinct from the patterns observed for cerebral cortical surface area expansion.

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We sought to explore the normal myocardial signal density (SD) levels during multidetector computed tomography coronary angiography (MDCT-CA) acquisitions and evaluated the impact of beam hardening artifacts. On the other hand, APO(a) was localized both in the stroma and within some macrophages. We aimed to establish early predictors of severe in-hospital outcomes in Emergency Department patients presenting with acute salicylate poisoning. Following transurethral microwave thermotherapy and routine post-procedure Foley catheterization at 1 of 9 clinical sites 186 patients meeting study criteria were randomized to receive a Spanner (100) or the standard of care (86). The oil concentrations in intertidal seawater, 15 days after the spill, were as high as 16,600 microg/L and appeared to decrease below the Korean marine water quality standard of 10 microg/L at most sites 10 months after the spill. Intended coping responses to cancer symptoms in healthy adults: the roles of symptom knowledge, detection behavior, and perceived threat. The time required for individual granules to change the light intensity (the releasing time) ranged from 0.15 to 0.70 s. Our clinical experience with robot-assisted laparoscopic surgery shows that it is a feasible technique for aortoiliac vascular and hybrid procedures.

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