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Adapalene is a topical retinoid with FDA approval for the treatment of acne vulgaris. Clinicians use retinoids are used to treat a wide variety of skin disorders. Adapalene also has multiple off-label therapeutic applications.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Risperdal, Buspar, Neoral, Lasix, Imitrex


Adapalene is a third-generation topical retinoid primarily used in the treatment of acne. Adapalene is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Adapalene gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Adapalene works under the skin surface to unclog pores and clear up pimples. Adapalene is also known as Adapalene, Adapen, Adaferin. Generic name of Adapalene is Adapalene.


Usual Adult Dose for Acne:

Adapalene 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Adapalene 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Adapalene dosage information


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adapalene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract. Rats were anesthetized for permanent placement of catheters for measurements of arterial and venous pressures. The three monkeys with reagin-mediated RR demonstrated bronchial hyperreactivity to CAR (p less than 0.25) but not PHY when compared with the three control monkeys. Systemic elastolytic granulomatosis with cutaneous, ocular, lymph nodal, and intestinal involvement. It is concluded that MOM, non-crystalline solid, did not show any toxic effects in this study and the maximum non-toxic dose is presumed to be 400 mg/kg or more in female Beagle dogs administered once daily for 26 weeks. Subsequently, the gram-negative colonization density increased in both groups but the increase was significant (p less than 0.001) only for patients on the open ward. Regulation of in vitro insulin release from a transplantable Syrian hamster insulinoma. Thus, a competitive binding immunoassay for thyroxine was demonstrated based on colorimetric measurement of dihydrofolate reductase activity. Physical exercise modifies the effect of high cholesterol-sucrose feeding in the rat. Subcutaneous and submucosal injections of paraffin were a wide-spread technique in plastic and reconstructive surgery during the early decades of this century.

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The bucco-lingual depth required to reach the main canal was calculated. A consideration of calcium and phosphorus metabolism including the normal and pathologic physiology of the parathyroid glands. DNA synthesis and cell migration were stimulated by isoproterenol, responses blocked by GABA and baclofen. Acquisition of growth autonomy and tumorigenicity by an interleukin 6-dependent human myeloma cell line transfected with interleukin 6 cDNA. Prolonged regulatory effect of thyroliberin on conditioned vegetative responses in hedgehogs. The mutations in gene controlling receptor to lipoproteids of low density, the genes Apo B, Apo A-1, and Apo E have a dominant role in the disturbance of lipid metabolism. Methods used involved self report questionnaires administered to mothers of forty-eight children attending the clinic. Clones containing rRNA genes were isolated from a gene library of Streptomyces lividans when RNA produced under heat shock conditions was used as a probe. Calculation of the probability of paternity by use of the binomial-formula.

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The procedure involved synthesis of 125-I-labeled 5-iodo-dCTP which was subsequently used as a precursor for the in vitro repair synthesis of HSV DNA. Viruses accumulated in sandy and slimy deposits of the sea bottom near the shore and could be easily released into water by means of simple mechanical shaking. Examination of cell-mediated and humoral immune response induced by human vascular antigens. Radiographs taken at yearly intervals reveal an initial widening of the periodontal ligament space that grew into a 3-cm mixed radiolucent and radiopaque tumor over a 4-year period. Comparative anatomy of the arteries of the forelimbs of domestic mammals.

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However, increasing amounts of normal serum did not result in comparable cell triglyceride accumulation. In terms of mechanism of release of bound biotin, we demonstrate that on binding to the Fab fragment of the mAb, the native tetrameric holoavidin undergoes dissociation progressively with time to monomers with no bound biotin associated with the latter. The lipid fractions demonstrated receptor acitity at 34 C but not at 0 C. The purpose of this study is to examine the relationship between HMO marketing strategies and selection bias in TEFRA At-Risk HMOs. Polymerase chain reaction (PCR) was applied to detect the structural change accompanying the activation of oncogenes in hematological malignancies and preleukemic states. GABA transmission was potentiated with Vigabatrin (gamma vinyl GABA, GVG), a suicide inhibitor of GABA transaminase. Addition of Cs A together with insoluble concanavalin A (iCon A) to LNC cultures resulted in suppressed lymphokine production, as assessed by measurement of migration inhibition factor (MIF), the generation of macrophage procoagulant activity (MPCA) and the release of lymphocyte-derived-macrophage chemotactic factor (LDCF). Initially, all eyes that had optic capture without vitrectomy also remained clear, but after 6 months, four of five developed opacification. Continuous 24-hour interactional monitoring in infants reared in two caretaking environments. The data are presented on the formation and main constitutional principles in the blood supply of the neuromuscular spindles in the human forearm and hand during embryogenesis and early postnatal life.

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The invariant handedness of the spindle pole, eyespot position, and mating structure position appears to be based on the inherent asymmetry of the basal body pair, providing an example of how an intracellular pattern can be determined and maintained. The anionic form of the selenohydryl group is a good nucleophile as well as a good leaving group. Prosthetic endocarditis and splenic abscess caused by Clostridium clostridiformis. BrdU incorporation by VSMCs in pulmonary arteries was not different in vehicle- and MCTP-treated rats for the first 48 hr after treatment. The effect of angiotensin II and indomethacin on uterine artery blood flow in pregnant monkeys.

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They disappeared more than five times faster than some Golgi enzymes such as Och1p, implying that the latter are recycled and perhaps partially retained. Metabolic and hormonal effects of muscular exercise in juvenile type diabetics. In both cases the linkage is effected through a disulfide bond provided by the cross-linker N-succinimidyl-3-(2-pyridyldithio)propionate. Is the enzymatic machinery for DNA precursor biosynthesis linked to the DNA replication apparatus?. Glucocorticoid deficiency due to secondary hypoaldosteronism was thought to have caused the Na loss. Three stages in the life cycle of the parasite--tick-derived sporozoites, intramononuclear schizonts, and erythrocytic merozoites--infect cattle. Tactile stimulation of the tentacles, rhinophores and lips excited Bn neurones, but inhibited Bb neurones.

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The presence of alkaline hexamethylenediamine (HMD) in the microcapsule core will affect the final pH of the microcapsules and may influence the stability of some drugs. Endotoxin-induced changes in hemodynamics, blood chemical values, regional blood flow, plasma enzymes, and energy supplies were measured at selected times during the first 6 hours after endotoxin was given. Experiments on animals and clinical observations over patients with infectious-allergic bronchial asthma and rheumatism showed that sodium nucleinate could abolish or suppress the intensity of immediate and delayed type hypersensitivity and the corresponding skin reactions to specific allergens. Under short-day conditions, the epididymis showed marked morphological changes including a decrease in luminal diameter, disappearance of spermatozoa, increase of interductal tissue, increase of intraepithelial lipofuscin deposits, the presence of phagolysosomes in the principal cells and macrophage-like cells, and a considerable modification of most clear cells. This growth factor seems a specific enhancer of collagen VII since the expression of laminin, collagen IV, as well as total protein was increased to a much lesser extent. Cross-sectional study using linked Ohio birth certificates and Medicaid files.

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Dehydroxylation of xanthurenic acid to 8-hydroxy-quinaldic acid. Although considerably more research is needed to identify the most effective approaches to the care of chemically dependent patients with pain, sufficient information now exists to support suggestions for guidelines. Serum thyroid hormones and ECG were evaluated before and serially during amiodarone (15 subjects) and benziodarone (15 subjects) administration. Nutrient mixtures with a high proportion of carbohydrate and protein appear the best dietary therapy to maintain body protein and support other organ systems and and cellular functions. Temperature effects on phosphate uptake and release in the isolated rabbit heart.

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Photon activation therapy as a method to improve effectiveness of extracorporeal irradiation of the blood is presented showing that one can in principle substantially increase the radiation dose to the leukemic cells and reduce the dose to red cells in transit through the irradiator. Cirrhosis of the liver was induced in rats weighing 120--140 g by CCl4 administration for a period of 2 months. Study results were analyzed with reference to long-term survival, morbidity and function. Nonachlazine was found to possess some sympatholytic and spasmolytic effect and could block the uptake of the exogenous NA greatly. The forward spatial filters are low-pass functions of spatial frequency, so more superficial external fields and potentials contain less spatial information than fields and potentials near the source.

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Sheets of RPE implanted into the lens-less eyes of larval hosts transformed into neurons and glial cells only when under the influence of host retinal factors. Acupuncture points are chosen according to involved energy pathways (meridians) and classical acupuncture combinations. The density of the nerves were similar to those previously observed in the adrenergic plexus. The 6 attributes of serum antibody were classified into three groups. Similarly, in pathologic conditions, ultrastructural abnormalities may reflect specific functional derangements of the cells. How soluble cargo molecules concentrate into budding vesicles is the subject of intensive current research. Evidence for a slow tissue adaptation to circulating thyroxine in patients with chronic L-thyroxine treatment. Effects of continuous oral administration of PCB (polychlorobiphenyls, 10-100 mg/kg/day, 4 weeks) on tissue levels of L-ascorbic acid (vitamin C), pyridoxal phosphate and riboflavin (vitamin B2) in various organs and on hepatic metabolism of L-ascorbic acid were examined in male Wistar rats weighing 150-250 g.

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The early closure of constantly contaminated infected wounds with the aid of urethane penicillin mixtures. Nevertheless, anatomic constraints often preclude surgery with generous margins and consequently local recurrence, particularly for conjunctival, nasal, and oral primary lesions, is usually the major first failure in treatment. In addition to IgG adn B-1-C, the glomeruli contained antigenic material that reacted with an antiserum to mouse mamary tumor virus. Skin boot versus knee joint--a sports medicine, orthopedic and biomechanical problem. To determine the effect of bilateral hypoglossal and and glossopharyngeal nerve block on epiglottic and soft palate position and tracheal and pharyngeal pressures in exercising horses. Characteristics of the formation and preservation of the conditioned motor defense reflex during the development of rats. Perioperative management of colon cancer under Medicare risk programs. We have constructed a YAC-based physical map of the 5q31.1 critical locus and localized the transcriptional transactivator Smad5 adjacent to loci showing consistent loss of heterozygosity in these disorders. Value of 1-alpha-hydroxy vitamin D3 in treatment of primary hyperparathyroidism before parathyroidectomy.

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Besides that, observed the destabilization of membrane systems, tracer penetration of the injured cells and inner organelles, the fall of redox potential of mitochondria, the disturbance of the acidic hydrolases compartmentalization, the accumulation of multilamellar bodies indicating the membrane alteration. Case of chemodectoma, originating from the vagus nerve, with marked somatic disorders. That of SB showed a tendency to increase as the adhesive layer became thicker. Nonspecific reactive hepatitis is a manifestation or complication of various diseases, being a variety of secondary hepatitis. Controversy exists over the origins of photosynthetic organelles in that contradictory trees arise from different sequence, biochemical and ultrastructural data sets. The production of an inducible antisense alternative oxidase (Aox1a) plant. The study aimed to compare the hardness and abrasion resistance of Ni-Cr alloys and determine whether there is a correlation between these 2 properties. We describe the case of a 28 years old caucasian woman with tuberous sclerosis diagnosed at 23 when she underwent nephrectomy for a left renal angiomyolipoma with massive hematuria. It is unique to cord sera and it bears immunological identity to human IgG. All strains were able to form dense plaque in the central fissure of the second molar.

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The second day of development was found to be the most sensitive period. Post-transcriptional control of catalase expression in garlic-treated rats. The effects of a plavix generic 75 glycerin-based blood analog on the testing of bioprosthetic heart valves. An experimental test setup is designed and implemented for this purpose. Collagen protein abnormalities produced by site-directed mutagenesis of the pro alpha 1(I) gene. Finally, a description is given of possible instrument extensions. Teaching the wise use of information--evaluation skills for nursing students. Three previously uncharacterized transcripts were found to be upregulated in the dentate gyrus 4 h following systemic kainic acid.

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Cell surface differences in ducts from cancerous and noncancerous human breasts. A comparative study on the use of ultram 50 mg cap flow cytometry and colony forming units for assessment of the antibacterial effect of bacteriocins. Toxicokinetic study in acute poisonings treated with activated charcoal. After treatment the left ventricular performance was found to improve in those who did not reveal evidence of LVH. Compounding of premigration trauma and postmigration stress in asylum seekers.

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Social-medical aspects of the demographic situation in contemporary Poland. The anatomical site of gastrointestinal bleeding may not be determined accurately with a scintigraphic bleeding scan. Enhancement of colony-stimulating activity (CSA) on murine CFU-gm by the H-4-II-E2 (H4) tumor cell line of the rat. The diagnosis is based on bone marrow examination showing marked megaloblastic changes whereas serum folate levels and red cell folate levels are normal. A 30-gauge canula was inserted into the tube at the reservoir end, and fluorescein-stained balanced salt solution was infused into the eye.

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