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Adipine (Nifedipine)

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Adipine is used to treat hypertension (high blood pressure) and angina (chest pain). Adipine is in a class of drugs called calcium channel blockers. Adipine relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Other names for this medication:
Adefin, Amarkor, Antrolin, Aprical, Belnif, Cardalin, Cardifen, Carditas, Conetrin, Cordafen, Cordalat, Cordipin, Corotrend, Duranifin, Farmalat, Fedip, Fenamon, Ficard, Ficor, Glopir, Milfadin, Nelapine, Nidipine, Nifcal, Nifecard, Nifeclair, Nifecor, Nifedel, Nifedicor, Nifedip, Nifedipino, Nifedipress, Nifelat, Nifensar, Nifestad, Nifezzard, Niften, Nilol, Nipin, Nirena, Oxcord, Pabalat, Tensomax, Viscard, Zenusin

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adipine PA 20. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adipine and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adipine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Cholecalciferol added to normal plasma did not become esterified. This is a simple and effective method for the elimination of chronic atrial fibrillation associated with atrial septal defects in adults. To account for this phenomenon, we have proposed that the extent of aminoacylation of a given tRNA species in vivo controls the relative rate of synthesis or turnover of that species. In human diploid cell strains, the substitution of galactose for glucose as the sole hexose in the medium had no measurable effect on the specific activity of the cell protein for any of the three enzymes of the Leloir pathway. Relationship between A-type and C-type particles in cells infected by Rous sarcoma virus. A 16-month preliminary study was performed on 58 patients for corrective surgery of hallux abducto valgus, with AO4 screw fixation.

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The month of birth distribution of SIDS cases did not alter significantly from a uniform, nonseasonal distribution (p greater than 0.25) but month of death was seasonally distributed (p less than 0.01). Urease activity increased from 4.18 nmol/min x mg protein (at 3 months) to 19.0 nmol/min x mg protein (at 2 years), reaching by 12 months of age the level observed in adults. It was concluded that the vulnerability of the second component of the conditioned response to cerebellar damage reflects an important role for the cerebellum in modulating the degree to which long-latency neural systems contribute to the ongoing performance of learned and unlearned behaviors. The findings at computed tomography (CT) were reviewed in 33 patients with laryngeal carcinoma classified as T1 at clinical examination. Intraperitoneal administration of oil-adjuvanted vaccines to Atlantic salmon pre-smolts has occasionally resulted in impaired growth and reduced carcass quality. Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein.

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The effect of intravenous glucose on ventricular vulnerability following acute coronary artery occlusion in the dog. On relationships between synthesis of DNA and incorporation of deoxythymidine into DNA during myocardial infarctions induced in rats by isoproterenol. Higher doses of MNCO have induced a second pattern of change in the pancreatic lobules of rats, which includes cystic and tubular ductlike structures that have been called cystic and tubular ductal complexes. The mean CT-MR registration error for the clinical data obtained without rigid head fixation during scanning is 1.4 mm, which is the highest mean error that we observed. On removal of the C3 or IgG Fc receptors, the quantity of mouse erythrocyte binding receptor remained unchanged. Cumulus expansion was maximal for oocytes incubated with mature FF and minimal for those incubated with EGF-free media.

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We found that full chimerism and graft-versus-leukemia (GVL) effects could be induced in these patients by donor lymphocyte infusions and withdrawal of posttransplantation immunosuppressive therapy. It is concluded that predictable changes in pain behaviors occur within infancy and toddlerhood. We could find no evidence to support a mixed-type receptor or the involvement of nicotinic receptors in the excitation of hippocampal pyramidal cells to cholinergic agents. The recurrence of angina-type pain within a few months of successful coronary angioplasty usually indicative of a diagnosis of coronary re-stenosis. Wound closure may be achieved by secondary intention, skin grafting, or flap closure. The results are discussed in terms of a possible mechanism of the synergism between 5-HT and tryptamine. A rationale for the management of periodontal diseases: effects of tetracycline on subgingival bacteria. It is a tumor, composed of atypical cells, which is neither frankly malignant nor so well organized as a benigh tumor.

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Even with present-day CT scanners (i)TNM provides no accurate staging and routine mediastinoscopy is necessary for precise mediastinal lymph node staging. This example should support the initiation of similar programs in other states. Cutaneous reactions to chlorpromazine as an occupational desease. Synthesis and analgetic activity of sulfur-containing morphinans and related compounds. Developing a competency-based orientation program: the challenge of a multidisciplinary pediatric unit. The reduction of merosin may account for the clinical phenotype of CMD and correlate with the white matter abnormalities in our patient. The combination of materials with each other demonstrated that none of the amalgams was particularly suitable as a repair amalgam. We now have studied which type of immune dysregulation leads to insulitis. Terms associated with gerontology include benign agism or senescence, as a normal consequence of the aging processes common to all biological forms of life.The age period, 65 to 85 years, does not necessarily imply senility, but the normal chronological aging of an individual in an industrialized, urbanized society. Regional localization of human beta-casein gene (CSN2) to 4pter-q21.

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Binding, internalization, and degradation of low density lipoprotein by normal human fibroblasts and by fibroblasts from a case of homozygous familial hypercholesterolemia. Administration of T4 resulted in a significant increase in the incidence of colon tumors in week 35. The results are compared with those of standard linear regression (SLR) filter. Children from the Autonomous Community of Madrid, Spain consume excessive sweets, which could be responsible for a higher prevalence of diseases related to this intake, such as caries, obesity and obesity-related associate diseases. Imported fire ant stings: clinical manifestations and treatment. The original peristaltic direction is preserved so that retroperistalsis in antiperistaltic loops may lead to patient discomfort and pulmonary complications. Glucose transporters of the glomerulus and the implications for diabetic nephropathy. The histochemical characterization of lipids by the Nile blue sulphate test revealed the neutral or triglyceride nature of the cytoplasmic droplets, both after the corn oil and oleic acid feeding.

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Its catalytic properties are similar to those of core polymerase. In 38 patients undergoing femoral artery profundaplasty and in 18 having simple mastectomy with pectoral node biopsy, a 6.2 per cent solution of sodium sulphan blue was injected peripherally to outline the lymph nodes in the groin or axilla. Differential diagnosis in a newborn with dysmorphic features and profound neurologic dysfunction should include the cerebro-hepato-renal syndrome of Zellweger. These results suggested that cyanocycline A binds to DNA, and that it inhibits nucleic acid synthesis. When a K-Complex was elicited, there were no differences in EEG activity prior to and following the stimulus. The time course of the increase suggests that CAIs induce reticulocyte synthesis of carbonic anhydrase. Formulas also are developed to approximate the prediction error variances for such models. L1210 cells stably transfected with pBKCMV-P1A expressed P1A mRNA and were lysed by the syngeneic P815A-specific cytotoxic clone CTL-P1:5, thus confirming that the tag-modified P1A protein underwent correct processing and presentation. Supraventricular and ventricular dysrhythmias, as well as conduction disturbances of varying severity are frequently observed in chronic obstructive pulmonary disease (COPD). Of the 322 isolates screened, 11 isolates were found to produce deoxynivalenol in concentrations ranging from 0.01 to 186 micrograms g-1.

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Gallium-68 labeled red cells and platelets: new agents for positron tomography. Cotrans-duction with bacteriophage P1 more precisely maps nuv at 0.3 min. These data suggest that both microvessel vasodilatation and recruitment are dual mechanisms of IBV change. Early recognition of the skin manifestations of this syndrome and careful follow-up are important to prevent the deleterious effects of hypocalcemia. Plants produce and emit a wide range of compounds whose common precursor is isoprene. Among them, MS-209, a novel quinoline derivative, is one of the most potent MDR-reversing agents: MS-209 at 3 microM effectively reverses MDR in various cell lines in vitro. MEM powers in the second harmonic component were highly correlated with FFT power in temporal frequency above 4Hz. In group 2, AUC, t1/2 and CL/f of lansoprazole were significantly greater, longer, and lower, respectively, than those in group 1.

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Antigenic competitor proteins were found in tumor and non-tumor tissue. Effect of streptozotocin on carnitine and carnitine acyltransferases in rat heart, liver, and kidney. As was observed with TRF, the in vitro TSH-releasing effect of the analogue was reduced in the presence of T4, and the analogue was inactivated by incubation with rat serum. The cyclin kinase inhibitor p16, encoded by the CDKN2A gene, suppresses the transformation of mouse embryonic fibroblasts by oncogenic RAS. Experience in the preparation of dry sorbed typhoid vaccine from soluble antigens. Although he was referred to our hospital in 1999, we had to refer him to another hospital for his regular outpatient hemodialysis. In our department, the first bridge to transplantation in using Thoratec artificial heart was performed in 1995. These considerations must be taken into account before embarking on an institutional bone banking program, to provide safe and satisfactory allogeneic bone for clinical use. baroreflex sensitivity was quantified by the alpha-index, at high frequency (HF, 0.15-0.35 Hz) and mid frequency (MF, 0.05-0.15 Hz), derived from spectral and cross-spectral analysis of spontaneous fluctuations in heart rate and blood pressure. The non-endogenous amino acid, homoglutamine, was used as an internal standard in verifying the consistent derivatization of amino acids and in quantifying amounts of glutamate and GABA released from the caudate-putamen tissue.

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The localization, molecular nature and secretion of Peptide YY (PYY), a putative gut hormone belonging to the Pancreatic Polypeptide family of peptides, was studied in pigs. Behavioral performance effects of nifedipine in normotensive baboons: single dosing. Adult-onset mesangiocapillary glomerulonephritis: a disease with a poor prognosis. This study documented the stronger adverse effect of widowhood on the psychological well-being of men than that of women and explained why this gender difference in the effect of widowhood exists. The effects of early gentling and shock on growth and behavior in rats. With the tumor negative for both ER and PR, on the other hand, there was little difference in tumor cell growth between the treated and control groups, and no inhibitory effect was observed after administration of P or coadministration of E2 and P.

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The latter showed better correlations with the variables related to smoking amount than the former. In this context, the current status and changing trends of antimicrobial resistance in Lebanon are addressed covering the most relevant bacterial, mycobacterial and fungal pathogens. Experimental results show that with the methods employed neither the trypsin inhibitor in the serum nor the inhibitor in the streptokinase nor the antistreptokinase in the serum significantly interfered with the results of titrations of total plasmin. The spontaneous firing of GP neurons is inhibited by stimulation of the GABAergic striatopallidal projection. Increased resistance in mice to Listeria monocytogenes after treatment with a fraction from an inflammatory granuloma. Quantitation of Hb a2 with DE-52 flonase dosage info microchromatography in whole blood as screening test for beta-thalassemia heterozygotes. Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons. The linear formula is analytically equivalent to known filtered-backpropagation formulas for Born inversion, and, at least in the case of small scattering objects, has advantages of computational simplicity and efficiency. To ascertain whether there is any relationship between the expression of particular blood group-related antigens (A, B, H, Lewis (Le)a, sialyl Le(a), Le(x), sialyl Le(x)) in a colorectal tumor, and a tumor having polypoid or non-polypoid growth, we examined 78 PG-type and NPG-type colorectal cancers.

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We report a 22-year-old very thin man, who showed various symptoms and signs of oculoskeletal muscle weakness, episodes of myalgia, prolonged diarrhea, severe myopia, perceptive deafness, electrocardiographic and electroencephalographic abnormalities, and endocrinological abnormality. Thus kidney lysosomes appear to be a target and possibly a mediator of iron toxicity in this tissue. We outline some of the possible data requirements of transmission models and we highlight the need for the collection of appropriate quantitative data, so that modellers can estimate specific parameters for their models. Effect of proteolytic enzymes on the hemagglutinating property of the parvoviruses, H-1, H-3, and RV. Multiple and multifocal carcinomas in female genital organs and breast. Vasodilatation as a therapeutic principle in the treatment of angina pectoris and recent heart infarct. Definitive radiation therapy may be used as primary treatment, or in management of endocrine treatment failure, and in postoperative residual or recurrent cancers. The increase in the excretion of the 11-oxy-17-oxosteroids with age is much more gradual.

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Substitution of corpus luteum effect by 17-alpha-oxy-progesterone-capronate. Main reason for non-participation was absence from school but a small number refused to participate. They also indicate a need for further exploration of the unexpectedly high levels of psychiatric morbidity among some ethnic elderly groups, can you take generic zyrtec while pregnant specifically the Dutch- and Italian-born. Thematic Apperception Test: some evidence bearing on the hero assumption. Hydrazine--a possible cause of isoniazid--induced hepatic necrosis.

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The nucleotide sequences of ten haemagglutinin genes of representative H7N7 equine influenza viruses isolated between 1956 and 1977 have been determined by primer extension sequencing. This ability to activate was not abrograted by trypsinisation of the cells. To determine whether the rat is a good animal model for the food effects observed with bidisomide but not with the structurally similar antiarrhythmic drug, disopyramide in man and to explore a reason for the differences in the food effects of these compounds. The various techniques for aerosol therapy are described, as applied to inflammations of the upper and lower airways. Spontaneous behavior and sleep-wakefulness cycle in isolated and paired REM sleep deprived-marihuana treated rats. Six months after the first operation she underwent a corrective re-operation for release from the PVO using EPTFE (expanded polytetrafluoroethylene) patch. If parenchymal phase imaging is indicated, the LVCT can be used as a bone subtraction mask and diagnostic scan, eg, for tumor imaging.

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We have determined the magnetic susceptibilities of nanogram quantities of many paramagnetic materials. Selection of patients for IVF therapy or alternative therapy methods. Reversibility of anatomical and functional asplenia by chronic transfusion diovan 160mg tab in a child with sickle cell anemia. Fluorometric determination of glucose in cerebrospinal fluid and blood by the revised 5-hydroxy-1-tetralone method. The DNA distribution was analysed by flow cytometry in biopsy specimens from the primary tumour. Radiographs were reviewed for reduction and evidence of postoperative change in reduction. The regressor animals developed a delayed-type hypersensitivity response against the tumor In vivo and their lymph-node cells produced macrophage migration inhibitory factor in the presence of tumor cells in vitro. The RBDI makes comparison between different heart valves easier and may prove important when making correlation with clinical observations. The steroid hormone may exert its influence on gene function through this interaction. Experiments designed to elucidate the mechanism of uracil degradation by E.

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Choline and the production of polycythemia by cobalt in the rat. Sampling was done through microdissection of frozen immunohistochemically stained 16 microm slices of tumors. Electrophysiological studies on the cerebellocerebral projection in the rat. Functional analysis of mononuclear cells infiltrating chlamydia medicine zithromax into tumors. Sequencing, expression pattern and RFLP mapping of a senescence-enhanced cDNA from Zea mays with high homology to oryzain gamma and aleurain. The initial impetus to develop standards of care came from the medical profession when it attempted to define quality of care. (2) Major alterations in the CH stretching, CH deformation and CC stretching regions indicate a different lipid architecture in the membranes from activated cells. A comprehensive study of genic variation in natural populations of Drosophila melanogaster. Turnover of antiplasmin, the fast-acting plasmin inhibitor of plasma.

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Dietitians as intervention specialists: a continuing challenge for the 1990s. Inhibition of bacterial IgA proteases by human secretory IgA and serum. Initial results with intra-tubal embryo transfer (IVF-IT-ET) in patients with cervix antibodies to spermatozoa antigens. In vitro data indicate that imipramine (IMI), a widely used tricyclic antidepressant drug, is N-demethylated by several isoforms of cytochrome P450, which include CYP3A4. Our case-control study of 299 Swiss patients with Type II diabetes included 147 patients with confirmed diabetic nephropathy. Subcellular distribution of the enzymes related to the cellular action of vasopressin in renal medulla. Cell type-specific regulation of beta2-adrenoceptor mRNA by agonists. The effect of heat shock on the relative activity of proteinkinase of Leishmania aethiopica. dulcis GGPPS gene and a green fluorescent protein was introduced into Arabidopsis leaves by particle gun bombardment, the chimeric protein was localized in chloroplasts, indicating that the cloned S.

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The enzymatic activity of aspirates of preovulatory human follicles. The purpose of this study was to determine whether vasoconstrictor use interferes with tear film adequacy by decreasing mucin-secreting goblet cells. Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. Copper concentration in hyperintense hepatocellular carcinomas of Long-Evans cinnamon rats on T1-weighted images. The median in vivo/in vitro LI ratio was 1-2, but for two-thirds of the patients it was only 1-1, suggesting a slight LI underestimation in vitro.

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Neurotensin-like immunoreactivity-containing cells first appear in the primordium of the n. Such an accumulation in the severely malnourished animals appears to be a compensatory cordarone 200 mg tablet in hindi mechanism for the increased cytoplasmic catabolism and loss of ribonucleoprotein material in order to facilitate additional protein synthesis for cell survival. The results support a basic conservation of the structure of the aminoacyl-tRNA carrying enzyme in evolution. We considered 58 centers of senology diagnostic imaging in the radiology departments of general hospitals in 8 Lombardy provinces. Sensory hyperacuity in the jamming avoidance response of weakly electric fish. Cell growth was suppressed significantly by combining 5-FU and a nontoxic dose of DP (2.5 micrograms/ml) as compared to 5-FU alone. Recent advances in electrochemical detection in capillary electrophoresis. This protein was recognized by antibodies against vitronectin (VN) in Western blots. A clonogenic assay revealed that concentrations of TGF-alpha greater than 10(10) M induced a significant increase in colony formation, indicating TGF-alpha to be a breast cancer cell growth factor. Serologic assessment was carried out in a sample of the population living in an area endemic for malaria in which control measures were being applied.

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