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Adlene (Adapalene)

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Adlene treats acne deep in the pores at the source, prevents new acne from forming and, as a result of reduced acne, restores your skin’s natural texture and tone. Adlene has been prescribed to more than 40 million people over the last 20 years.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Soflene, Vandep

Similar Products:
Abilify, Zantac, Clarinex, Glucotrol, Rhinocort, Avana

Also known as: Adapalene


Adlene is a third-generation topical retinoid primarily used in the treatment of acne. Adlene is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Adlene gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Adlene works under the skin surface to unclog pores and clear up pimples. Adlene is also known as Adapalene, Adapen, Adaferin. Generic name of Adlene is Adapalene.


Usual Adult Dose for Acne:

Adlene 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Adlene 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Adlene dosage information


If you overdose Adlene and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Adlene dosage information

Side effects

The most common side effects associated with Adlene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Adlene if you are allergic to adapalene.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions.

It is not known whether adapalene passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

It is not known whether Adlene will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Adlene is not approved for use by anyone younger than 12 years old.

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Evaluation of several tests in screening for chloroquine maculopathy. Serum-containing and serum-free media conditioned by the nonmotile, nonmetastatic G Dunning subline inhibited the motility of the highly motile, highly metastatic MAT-LyLu subline. Thus, our developed reporter system can be useful in investigating the direct cell-to-cell interaction between stromal and hematopoietic cells. It is of interest that two lymphoblastoid cell lines, RPMI1788 and Kaplan, were insensitive to HIF. Our observation of this patient after biopsy and control of hemorrhage is the subject of this report. The biotin-avidin immunoperoxidase staining method and antisera against highly purified porcine relaxin were utilized to localize relaxin in the male genital tract. Laser Raman spectroscopy and circular dichroism studies of the peptide hormones mesotocin, vasotocin, lysine vasopressin, and arginine vasopressin. The improved procedure eliminates the need for large numbers of replicate samples for several assays and, at the same time, provides a more sensitive method for recovery of total platelet serotonin. Contrast medium reflux in the jugular vein in peripheral bolus injection.

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The incidence of SLBT in 154 patients with LACC entered in six consecutive chemoradiotherapy protocols between February 1982 and June 1987 was determined. HIV-1 infection results in the clinical presentation of a disease process that encompasses a spectrum of illness from asymptomatic infection to acquired immune deficiency syndrome (AIDS). Cervical or cervicothoracic fixation was performed in 39 patients. Selective absorption with homologous LPS and heterologous LPS showed that the antibody response was specific for E. The titre and that dilution required for the complete detection of antigens can be determined. The MAP solutions are complete and are more accurate than those of other tested algorithms. Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny. Six-year follow-up of a case of radiation injury following treatment for medulloblastoma. coli has proven to be a useful model system to determine the effects of relative humidity, particle size and particle coating on efficiency of biolistic transformation.

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Because of the absence of cytotoxicity, and the ease of handling and cryopreservation, while maintaining liver specific functions, the described system appears to be valuable for murine liver cell encapsulation. This study aims to clarify clinicopathologic characteristics of synchronous primaries of the extrahepatic bile duct and gallbladder. Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. The nasopharynx is a natural reservoir for several bacterial species, including Streptococcus pneumoniae and Haemophilus influenzae. These results show that a short-term multifaceted smoking cessation program implemented over 5 months can produce a decrease in cigarette smoking. A 25 kDa MP-defective full-length cloned PVX genome carrying a beta-glucuronidase (GUS) reporter gene was co-bombarded with 35S promoter constructs containing either the 25 kDa MP gene of wild-type PVX, the MP gene of either of two tobamoviruses (tomato mosaic virus or crucifer tobamovirus), red clover necrotic mosaic dianthovirus (RCNMV) or brome mosaic bromovirus (BMV). The interpersonal model of group psychotherapy emphasizes the critical nature of peer interactions and consequent dynamic interpersonal learning.

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Determination of ceruloplasmin activity in plasma in progressive scleroderma. All the benign lesions were excised without complication or recurrence. Determination of tactile bone-conduction (BC) thresholds is essential to provide proper diagnosis of individuals with profound hearing loss. Ambulatory 24-h esophageal pH-metry was performed at 0 and 3 months. Plasma estrogen and progesterone levels after mating, and during late pregnancy and postpartum in cows. Effect of proteolysis in the autolysis loop on catalytic efficiency and factor Va binding. This effect was mimicked by the kinase-dead and wild-type p70s6k constructs, which also blocked insulin-induced dissociation of 4E-BP1 from initiation factor 4E. Spontaneous activity and behavioral responses in an open-field are improved and some of the grafted rats show a complete recovery of amphetamine-induced hyperactivity. In addition, the size of the splenic myeloid stem cell compartment, as measured by granulocyte-macrophage stem cell colony formation in soft agar, was markedly expanded.

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Metallic particulate debris was recovered from gas from all 10 insufflators. The expression of resistance phenotypes and the tetracycline efflux system were temperature sensitive at 42 degrees C. A novel activation-induced suicidal degradation mechanism for Akt by selenium. Importance of the study of organic urinary sediment by the use of modern technics. Magnetic resonance spectroscopy of the living brain is described.

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Determination of lactate kinetics in the human analysis of data from single injection vs. Acceleration of intimal atherogenesis through prior medial injury. It appears that application of small amount of PGE1 can be a useful mean for the treatment of congestive heart failure after valvular surgery. Coefficient alpha of the dose-proportional yield component, when compared between 241Am alpha-particle irradiation and 137Cs gamma-ray exposure, is found to increase approximately in proportion to dose-mean restricted linear energy transfer, which indicates an underlying pairwise molecular lesion interaction on the nanometer scale. Congenital hepatic fibrosis may present as a cause of portal hypertension in adolescents, in young adults, and, rarely, in older adults. To date, the specific circumstances during which the reaction may occur have not been well defined. The coronal forehead lift has produced excellent results in the rejuvenation of the upper face. For the first time, we were able to measure the influence of joint movement on the intraarticular process of nutrition under physiological and pathological conditions. There is no correlation between the degree of resistance to cyanide and cytochrome d content. Nitric oxide (NO), besides being the most important endothelium-derived relaxant factor in blood vessels, is supposed to be involved in regulating the interactions among endothelium, adhesive molecules, and leukocytes.

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The activity of metabolic pathways involved in the formation and utilization of phosphoribosylpyrophosphate (PRPP) was studied in. Four patients had localized noradrenaline elevation and the diagnosis of phaeochromocytoma was confirmed at operation. Pair-rule expression of a cell surface molecule during gastrulation of the moth embryo. Immunohistochemical analysis provided evidence that the majority of ZF cells have IL-6 receptors, TNF type 1 receptors, and TNF type 2 receptors. Claude Bernard discovered the function of the pancreas in digestion.

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Regional pulmonary blood volume in patients with abnormal blood pressure or flow in the pulmonary circulation. From the Austrian Society of Neurology and Psychiatry to the Austrian Society of Neurology. The tumor was attached to the periphery of the anterior horn of the lateral meniscus, to the anterior tibial plateau, and to the fat pad. The increased number of patients with implantable cardiac devices presents a unique challenge to physicians performing office-based electrosurgical procedures. About the single time double comminssurotomy for mitral and tricuspid stenosis.

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Ultrastructural reappraisal of endometrial glandular changes in women wearing Cu-T200 device for longer duration. A large number of non-human mammalian larynges have been studied in an attempt to relate body mass to maximum glottic and tracheal area in order to confirm symmorphism. The threshold induction temperature of the 90-kDa heat shock protein is subject to acclimatization in eurythermal goby fishes (genus Gillichthys). Highly significant levels of mRNA were detected for the GluR1, GluR3, and GluR4 subunits. Generally, patients prefer more defined and invaginated folds, but not necessarily a very high fold, since the latter will often look unnatural or overdone in the Oriental face. Variation in time of abstinence between 1 and 3 days influenced semen volume and sperm content as well as the content of 19-hydroxylated PGs, but did not affect sperm motility or the concentration of PGE or PGF.

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The hepatic steatosis secondary to IVH may be treated by lowering the dextrose concentration of the infusion or by administering dextrose-free amino acid solutions. Serum angiotensin converting enzyme (ACE) activity in patients with chronic renal failure (CRF) on regular hemodialysis (HD) was measured. Robert Koch (1843--1910): founder of the science of bacteriology and discoverer of the tubercle bacillus. The group comprised 45 male (26 per cent) and 127 female (74 per cent) patients. These data confirm that for stroke patients there is sustained activation of the blood coagulation system like in unstable angina and myocardial infarction these abnormalites may have unfavourable prognostic significance. Protease-deficient mutants of Pseudomonas aeruginosa: pleiotropic changes in activity of other extracellular enzymes.

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Cefuroxime: mechanisms of action, antimicrobial activity, pharmacokinetics, clinical applications, adverse reactions and therapeutic indications. It shows remarkable differences from other known species of Thynnascaris in respect of body size, length of the oesophageal appendix and intestinal caecum, location of nerve ring feldene gel para que sirve and excretory pore, on the papillae on the lips arrangement, type of the striations on the cuticle, vulva position, arrangement of caudal papillae and size of the spicules. To identify the problems nurses encounter in a Neonatal Unit and adapt them to the corresponding NANDA (North American Nursing Diagnosis Association) diagnostic categories for their validation in our environment. Male and female scents did not elicit significantly different amounts of scent marking. High agreement of the evaluaters was achieved for image contrast and delineation of organs, less agreement in detection of vessels and artifacts in cystic structures, respectively. These results suggest that post-translational modification of Crk II-23, such as physical association to cellular proteins, induces binding of Crk II-23 to EGFR in quiescent cells.

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In 1987, striped bass (Morone saxatilis) that were nearly dead (moribund) were captured by hand net, and apparently healthy striped bass were caught by hook and line from adjacent waters in the Sacramento-San Joaquin Delta or, alternatively, caught by hook and line from the Pacific Ocean. Toxicity of a piperazine-carbon disulfide-phenothiazine preparation in the horse. A comparison of the skeletal effects of estrogenic hormone in vitamin C depleted young and old guinea pigs. TGE is self-limiting on the majority of pig-breeding farms but the virus may persist in particular conditions and an enzootic form of the disease will appear in this case. Based on our data and the results of previous large clinical studies, a list of disadvantages and advantages is offered. Changes in expression of ion channels and aquaporins mRNA during differentiation in normal human nasal epithelial cells. The replication of extrachromosomal rDNA molecules from the macronucleus of Tetrahymena was studied by electron microscopy. Fewer than half these patients had both increased breath and faecal excretion of isotope and faecal (14)C alone was occasionally normal with an ileal resection of 50 cm of more. Additional studies are needed to determine whether similar inequalities of PT/ is phenergan a scheduled drug OT use are found in other populations and whether rehabilitation is effective in various subgroups. For example, where is the evidence for the routine clinical examination-and might the radiologist with a chest X-ray and abdominal ultrasound do better?.

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Two exceptional cases are reported, and diagnosis and treatment are presented in the light of the current literature. Ultrastructure and cytochemistry of the thrombocytes in healthy persons and in blast leukosis patients. The fluorescence results indicate that both peptides are trapped by APols and the CD results that they adopt a beta-sheet conformation. Prenatal weight gain advice: an examination of the recent prenatal weight gain recommendations of the Institute of Medicine. Three involved epithelial lesions with randomized multimodality trials alone or in combination. The aim of this study was to investigate whether these effects manifest as changes in pepsinogen I and gastrin concentrations. Submissive animals (CA) demonstrated a decrease of travels in the open field test and an increase of immobility time in the Porsolt test. Free PSA was heat-stable at 56 degrees C and displayed no change after freezing-thawing.

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Similar changes were not observed in the presence of identical concentrations of citrate, acetohydroxamic acid, and N-sulfo-2 amino tricarballylate (an analog of phosphocitrate), emphasizing the unique interaction of phosphocitrate with the struvite crystal lattice. On the other hand, the scale for reporting of results should be standardized. Pups nursed up to 25 days had a smaller body weight, shorter intestine, lighter mucosa, and lesser mucosal protein content. Thus, asymmetry of the elevator muscles during mastication was a common finding in normal subjects. Genetic control of radiation sensitivity in Schizosaccharomyces pombe. PRA values 5 min after venepuncture in the total group of infants and children were significantly higher (P less than 0.001) than venepuncture values. During treatment by the PUVA method this activity rose gradually above the values in the control group. The effect of hypokinesia on the hemocoagulatory and fibrinolytic properties of aorta, myocardium and venae cavae was studied.

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The PCR products were analyzed by the PAG horizontal electrophoresis with discontinuous buffer system and then silver stained. Ulcerative colitis (UC) is a chronic inflammatory bowel disease with frequent exacerbations, including the risk for toxic megacolon and severe complications. These results suggest that at least some steps in the biology of cortical granules may be mediated by SNARE homologues, and this finding, along with the unique biology of cortical granules, should facilitate examination of specific events of the fertilization reaction and the mechanism of stimulus-dependent exocytosis. Netilmicin exhibited little activity, whereas tobramycin and sisomicin were active against approximately two-thirds of the strains. The patients theolair medication were lost to follow-up but died soon after diagnosis. which are resistant to newer beta-lactam antibiotics was investigated by isoelectric focusing. Intracytoplasmic membranous structures, known as annulate lamellae were seen in a malignant mesenchymal tumor. Suppression of pancreatic lipase activity by 8-oxyquinolin and tetracycline derivatives in acute pancreatitis.

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