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Admadol (Tramadol)
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Admadol

Admadol is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Admadol is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Anazac, Cadol, Cosdol, Dolomed, Dolotram, Dolstar, Esgiypyrin, Euphodol, Jpdol, Kevtram, Mandol, Meridol, Movon, Nopidol, Pentazen, Rybix, Spasteez, Tramaflam, Tramagesic, Tramasol, Tramex, Tramoflex, Tranat, Trandol, Trapain, Tromar, Typhon, Urogendo, Vintram, Zytram

Similar Products:
Zudena, Duricef, Arcoxia, Ceftin, Daklinza, Cozaar

Also known as: Tramadol

Description

{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.

Dosage

Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Admadol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Admadol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Admadol dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Admadol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Admadol if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Admadol should not be given to a child younger than 12 years old. Admadol ER should not be given to anyone younger than 18 years old.

Do not give Admadol to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Admadol. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Admadol is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Distribution of 131I-labeled Bothrops erythromelas venom in mice. Genes and proteins determining species specificity of avian influenza viruses as well as possible emergence of influenza pandemic caused by H5N1 strain are discussed. Following surgery, pathologic findings of the tumor demonstrated pure choriocarcinoma without combination of other germ cell tumor elements. In randomized trials, the treatment assignment mechanism is independent of the outcome of interest and other covariates thought to be relevant in determining this outcome. No long-term study found any evidence that surgery would prevent knee osteoarthritis. These additions are incorporated in a new version of the SHIFTS program. For the retrospective arm, preoperative CT images of all cases were reviewed electronically in a blinded fashion by the senior author and a prediction was made for the site of attachment. For the infinite allele model, the analysis shows that more precise estimates of the frequency of ancestral alleles can greatly improve the reliability of the estimate of genetic identity in the case of ITL. Recurrent ischemic stroke in a patient with idiopathic thrombocytopenic purpura. The patient was successfully treated by endovascular embolization at the orifice of the pseudoaneurysm followed by the total ICA trapping technique using electrolytically Guglielmi detachable coils (GDCs) and injection of N-butyl-2-cyanoacrylate (n-BCA).

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In this context, the present review examines the effects of cannabinoids and of the pharmacological manipulation of the endocannabinoid system, in cardiovascular pathophysiology. Additional experimental data also support the diffusion of FADH(2) between TftC and TftD without direct physical interaction between the two enzymes. Results were compared to hormone receptor expression and proliferation index. The repertoire of virulence determinants promoting EHEC disease is encoded on both the main chromosome and virulence plasmid. Furthermore, the HIV-1 Gag precursor is generally inefficiently processed and is poorly secreted from mouse and rat cells in a largely noninfectious form. Chemical control against this species is difficult because of its cryptic habits and is mainly based on the repeated application of large quantities of synthetic insecticides. Healthy participants wore two lower intra-oral appliances retaining four dentine samples for four treatment days for each period of the study. We performed a population-based retrospective cohort study to determine the morbidity of SE. The impact of matrix loading and protein molecular weight was assessed with the model proteins lysozyme, BSA, alcohol dehydrogenase and thyroglobulin. To describe the implementation of the European Foundation for Quality Management (EFQM) model as a quality framework for improving a psychiatric hospital ward.

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Subsequent 48-trial testing sessions were then used to test for detection of each stimulus in presented pairs, and test discrimination between the member stimuli of each pair. The activity of the transporters was determined electrophysiologically using the whole cell configuration of the patch-clamp recording technique. Drug efficacy analysis showed that ATA nanoparticles were as effective as free ATA against estrogen receptor positive breast cancer cells, but much less toxic towards human endothelial cells. Management of incomplete regional anaesthesia in Germany: results of a nation-wide survey. Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression. However, very little information is available on how efficiently external carbon is utilized by microorganisms and transported to consumers of higher trophic levels. From June 2009 through May 2010, 61 prospectively identified families completed a cost diary, documenting the numbers of missed school days for the child and missed employment days for the adult caregiver(s) over the treatment course. Elevated levels of c-reactive protein (CRP) are known to be associated with insulin resistance and metabolic syndrome in adults. Most dentulous unilateral cleft lip and palate patients show a tendency toward lingualized occlusion in lateral segment teeth. We suggest that the prevalence of the metabolic syndrome in cohort studies should be based on two consecutive measurements of the laboratory components in the syndrome definition.

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Transgenic plants showed markedly increased accumulation of transcripts and higher cysteine content compared with the wild-type. Diffuse liver diseases in neonatal and pediatric liver transplant candidates: a pictorial essay. The study design was ecological, with the urban areas of a medium-size municipality in Minas Gerais State, Brazil, as the units of analysis. Staff performance was evaluated before and after access to the resources using self-administered Likert scales, observation and a focus group. There is no close connection between either underlying disease or symptoms and cause of the complication.

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Partial bladder outlet obstruction successfully created a hyperactive (unstable) bladder, typified by increased BC, RV, frequency of SA and a marked decrease in compliance. These results are consistent with a strong electronic coupling or Dexter-type energy transfer as the dominating mechanism. The other concept is that accelerated repopulation of tumor cells occurs in a later period of radiation therapy. A case-control study of GST polymorphisms and arsenic related skin lesions. Sulindac treatment in hereditary non-polyposis colorectal cancer. In a defined population aged 65 years or older, baseline interviews captured self- or proxy-reported history of cardiovascular illness. Faster, simpler, more-specific methods for improved molecular detection of Phytophthora ramorum in the field. In the meantime, almost all large statutory health insurance providers in Germany have joined this healthcare project. Additionally, the effect of HO-1 on osteoblasts appears different to that seen in adipocyte stem cells.

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Effect of IGF-II (insulin-like growth factor-II) genotype on the quality of dry-cured hams and shoulders. A consideration of recent advances leads to a packaging principle for gene regulation. The collection included approximately 100 strains of Gram-positive (Firmicutes, Arthrobacter) and Gram-negative bacteria (Bacteroidetes, gamma-Proteobacteria, and alpha-Proteobacteria) resistant to aminoglycoside antibiotics (gentamycin, kanamycin, and streptomycin), chloramphenicol and tetracycline. Humanistic outcomes included the mental and physical components of the 12-Item Short-Form Health Survey (SF-12) and patient satisfaction with health services related to their diabetes care. Little is known about how Indigenous adolescence differs from mainstream adolescence, or how Indigenous adolescents manage chronic conditions. Literature concerning the indications for, and therapeutic levels of, lithium and the associated acute and chronic risks of therapy was scrutinized as part of updating clinical practice guidelines. Many patients have been identified with good graft function despite the presence of circulating donor-specific HLA antibody. The aim of the present study was to assess predictive abilities of carboxypeptidase-B activation peptide (CAPAP-B) and soluble L-selectin (sL-selectin) using samples collected on admission to hospital.

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Consistent with its prominent antiproliferative effect, PD98059 induced a remarkable G(1) cell cycle arrest, followed by a modest apoptotic response, in these tumor cells. Murine neutrophils were isolated from bone marrow and incubated with the neutrophil-targeted near-infrared imaging agent Neutrophil Elastase 680 FAST for proof of principle experiments, verifying that the elastase-targeted fluorescent agent is specifically cleaved and activated by neutrophil content after lysis or cell stimulation. Myocardial triglyceride content and myocardial function were measured in 38 T2DM patients and 28 healthy volunteers in the same range of age and BMI by proton magnetic resonance (MR) spectroscopy and MR imaging, respectively. Statistically insignificant but marginally higher reduction in PUSH 3.0 scores and ulcer size were seen with topical phenytoin treatment. It was found in this study that stable expression of small hepatitis B surface antigen (SHBs) in HepG2 and Huh7 cells increased susceptibility to apoptosis. Unlike what is seen for SDHWT and SDHY236F, the catalytic turnover rates of SDH R55M and SDHH57A are relatively insensitive to pH (approximately 60 and 200 s(-1), respectively). In digital subtraction radiography, image registration is one of the important prerequisites to match the reference and subsequent images. This leads to new possibilities for prevention and therapy of diseases, mainly of the gastrointestinal organs. Recurrence patterns of intraductal papillary mucinous neoplasms of the pancreas on enhanced computed tomography.

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Secretory phospholipase A2 (sPLA2) represents a family of small water-soluble enzymes that catalyze the hydrolysis of phospholipids in the sn-2 position liberating free fatty acids and lysophospholipids. Epiaortic ultrasound and transesophageal echocardiography screening are more accurate and more accessible to the operative team than any other available modality to diagnose atherosclerosis of the aorta. No standard treatment guidelines exist for late acute aortic dissection after CABG. The nail-bone constructs were submitted to axial distraction to test compression, four-point bending and torsion. Patients were followed for 3 to 96 months with a mean of 43 months. A total of 100 working dies for fixed partial denture (FPD) abutments were prepared to fit 50 three-unit fixed-fixed conventional FPDs. Protective efficacy of crude virus-like particle vaccine against HPAI H5N1 in chickens and its application on DIVA strategy. The contribution of D1 to this appeared to be small in AKR/J and SAMR1, but substantial in SAMP6. Eleven patients underwent mitral valve plasty and valve replacement was carried out in seven.

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The temporal course of the dominant motion percept generated by the iterative interplay between motion and form pathway is in line with data of ocular following responses in primates and humans. The fraction of cells surviving after the combination treatment with 2 Gy of radiation (SF2) was compared with that of the fraction of cells surviving after treatment with irradiation alone. The ADL section of Tamai score and the one we used correlated well with each other and patient satisfaction. To address the issue in SVDD methodology, we propose a new SVDD by introducing new distance measurements based on the notion of a relative density degree for each data point in order to reflect the distribution of a given data set. Changes in body temperature influence the scaling of VO2max and aerobic scope in mammals. In all cases the results showed the effectiveness of the GRID-FLAP method and its potential use in applications such as identifying selectivity targets and tools/hits for new targets via the identification of other proteins with pharmacophorically similar binding sites. Massive copper and what drug class is claritin selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement.

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