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Alertec (Modafinil)

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Alertec is used to treat excessive sleepiness caused by narcolepsy or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Nuvigil, Aristocort, Tricor, Suprax, Lipitor

Also known as: Modafinil


How Alertec works to help increase wakefulness and decrease sleepiness isn’t clear. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain.

These actions may result in stimulation of brain activities, which could make you feel less tired.

How long does it take to work?

Alertec begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working.


Dosage for adults is 100 mg per day. Take with or without food.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Alertec are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Alertec can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Alertec and other medications

Below is a list of medications that can interact with Alertec. This list does not contain all drugs that may interact with Alertec.

Before taking Alertec, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Drugs that change the effects of Alertec

Several medications can lessen the activity of an enzyme called cytochrome P450 3A4 in your body. Taking these drugs with Alertec can cause your body to get rid of Alertec more slowly. This can cause more Alertec side effects.

Examples of these medications include:

  • antiviral medications such as:
    • cobicistat (Tybost)
    • darunavir (Prezista)
    • ritonavir (Norvir)
    • Viekira Pak, Viekira XR (dasabuvir, ombitasvir, paritaprevir, ritonavir)
  • antifungal medications such as:
    • fluconazole (Diflucan)
    • itraconazole (Sporanox, Onmel)
    • ketoconazole
  • antibiotic medications such as:
    • clarithromycin (Biaxin)
    • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin)
  • heart medications such as:
    • amiodarone (Pacerone, Nexterone)
    • diltiazem (Cardizem, Cartia XT, Diltzac, Taztia XT, Tiazac, others)
    • verapamil (Calan, Verelan)
Drugs that may be affected by Alertec

Alertec can increase the activity of an enzyme called cytochrome P450 3A4 in your body. This can cause your body to get rid of certain medications more quickly. As a result, these medications may become less effective.

Examples of these medications include:

  • oral contraceptives (consider using a backup method of birth control while taking Alertec, and for one month after stopping it)
  • cyclosporine (Neoral, Sandimmune)
  • midazolam
  • triazolam (Halcion)
Alertec can reduce the activity of enzymes called cytochrome P450 2C19 in your body. This can cause your body to get rid of certain medications more slowly. This may cause more medication side effects.

Examples of these medications include:

  • clomipramine (Anafranil)
  • diazepam (Valium)
  • omeprazole (Prilosec)
  • phenytoin (Dilantin, Phenytek)
  • propranolol (Inderal LA, InnoPran XL)
Many other medications may be affected when taken with Alertec. If you take other medications, talk to your doctor and pharmacist about how to avoid potential interactions.

Monoamine oxidase inhibitors (MOAIs)

Taking Alertec with monoamine oxidase inhibitors (MAOIs) might lead to dangerous side effects such as very high blood pressure, chest pain, severe headache, and increased body temperature. Alertec should not be taken within 14 days of using an MAOI.

Examples of MAOIs include:

  • isocarboxazid (Marplan)
  • linezolid (Zyvox)
  • phenelzine (Nardil)
  • selegiline (Eldepryl)
  • tranylcypromine (Parnate)

Taking Alertec with warfarin (Coumadin, Jantoven) may make your body get rid of warfarin more slowly. This may increase the effects of warfarin and increase your risk of side effects such as bleeding.

Alertec and herbs and supplements

Alertec may interact with certain supplements or herbal products you may be taking. Examples of these include:

  • acacia rigidula
  • bitter orange
  • green tea
  • guarana
  • hordenine
  • Indian snakeroot
  • octodrine
  • St. John’s wort
  • yohimbe

Taking Alertec with marijuana might change how marijuana affects you. Alertec alters enzymes in your body that control how quickly the body gets rid of marijuana chemicals that cause you to get high. This might increase or decrease the effects and side effects of marijuana.

Alertec and foods

Alertec may interact with certain foods you may eat.

Fruit juices

Drinking certain fruit juices, such as grapefruit juice and orange juice, while taking Alertec might change how your body handles the drug. This could increase the amount of Alertec in your body and increase your risk of side effects.

Foods and beverages that contain caffeine

Caffeine in foods and beverages might add to the stimulant effects of Alertec. This can increase the risk of stimulant-related side effects such as anxiety, nervousness, trouble sleeping, and others.

Examples of foods and drinks that contain caffeine include:

  • coffee
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Surfactin strongly blocked the proliferation of medicine protonix 40 mg LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexin V staining, and altered levels of poly (ADP-ribose) polymerase, caspase-3, p21(WAF1/Cip1), p53, CDK2 and cyclin E. The adsorbed amounts measured with the different methods were different due to large amounts of water in the films. i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules. Effects of acute and chronic valproate treatments on p-CREB levels in the rat amygdala and nucleus accumbens. Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies. Dye-sensitized solar cells were made by using nanocrystalline titania deposited on Fluorine-doped SnO2 (FTO) electrodes. Dynamics of successive changes in the artificial associative culture of sulphate-reducing bacteria was investigated under biofilm formation on steel 3 specimens. The lectins differed in hemagglutinating activity, with the magnitude of the activity correlating with the ionic strength of the buffer required to elute the lectin from the DEAE-cellulose column. We investigated whether CA estimated approximately 30years earlier in young adulthood predicted lifestyle-related risk factors and two-year survival in first myocardial infarction (MI) male patients.

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Shorter, 1-day or 3-day desipramine treatments, however, had neither synaptic nor behavioral effects. The purpose of this study was to establish lateral cephalometric soft tissue norms for adolescent Kuwaitis and to compare these norms to those of the common analysis systems. No inversion effect was observed for discriminations involving houses. The actual funds are managed by the hospitals, and this allows hospital staff to provide optimum care for trauma patients. Friction landmarks were observed on the surface of the fixation screw, which could be responsible for the generation of high internal stresses. Fluoroquinolone antibiotics (FQAs) are widely used in dental and medical therapy. The dental operations included exodontia (28), scaling (29), endodontics (12) and minor oral surgery (11).

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