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Alphadol (Calcitriol)
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Alphadol

Alphadol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands are not working normally. It is also used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone and metabolic bone disease in people with kidney disease.

Other names for this medication:
Alcee, Alfacip, Alfarich, Alphadol, Arachitol, Biocal, Biocitral, Bonestat, Bonetuf, Calbory, Calcigra, Calcimet, Calcit, Calday, Caldikind, Calgel, Calosto, Calotec, Calsure, Caltop, Calvical, Carcal, Cholical, Coecoral, Duracal, Fovit, Lctrol, Novadee, Nutribone, Ostonex, Ostriol, Politrol, Qpcal, Rical, Roical, Romical, Solbiocal, Sorvate, Statbone, Trolec, Vezocal, Vitalpha

Similar Products:
Glucotrol, Zyprexa, Celebrex, Pamelor, Provera, Famvir, Trileptal, Colcrys

Also known as: Calcitriol

Description

Generic Alphadol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alphadol are intestine and bone. Generic Alphadol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alphadol may also act on the kidney and the parathyroid glands. Generic Alphadol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alphadol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alphadol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alphadol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alphadol produces other independent beneficial effects. Alphadol is also known as Calcitriol. Generic Alphadol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alphadol is Calcitriol. Brand name of Generic Alphadol is Alphadol.

Dosage

Generic Alphadol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alphadol suddenly.

Overdose

If you overdose Generic Alphadol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alphadol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Alphadol if you are allergic to Generic Alphadol components. Do not take Generic Alphadol if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Alphadol if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Alphadol taking suddenly.

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Mortality of children under the age of five remains one of the most important public health challenges in developing countries. Value of admission NT-proBNP in predicting in-hospital mortality in decompensated systolic heart failure. Modulating miRNA function has emerged as a new strategy to produce virus resistance traits1-5. A review of the literature describing the histopathological and genetic associations of stromal dystrophies, suggest it may be possible to differentiate dystrophies based on their clinical manifestations, and appearances of CM and OCT images, with or without the use of genetic testing. In the Australian context, there is minimal online information available to families beyond early intervention. Only the ErbB3-deficient MIA PaCa-2 cells displayed persistent Akt activation and ongoing proliferation in spite of erlotinib treatment. Attention to bodily sensations and symptom perception in individuals with idiopathic environmental intolerance. Dexmedetomidine Reduces Perioperative Opioid Consumption and Postoperative Pain Intensity in Neurosurgery: A Meta-analysis.

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This article presents an overview of nanobiosensors and nanoprobes. Novel design for a wearable, rapidly deployable, wireless noninvasive triage sensor. Only two of six cases at our institution fit the classic picture of postpartum infection complicated by OVT. In general, Notch is a representative signal which controls morphosis and differentiation of cells, but its role in human odontogenic neoplasms, especially in ameloblastoma and its malignant counterpart, ameloblastic carcinoma, is not known. The cutaneous silent period (CSP) is an interruption of electromyographic activity produced by a painful stimulation delivered in homotopic cutaneous territory. The meta-analysis was performed using the random-effects model for the AUROC, summary receiver operating curve techniques, as well as meta-regression approaches. Effect of guest-host hydrogen bonding on the structures and properties of clathrate hydrates. We do not know if they actually prevent pain from starting in the first place.

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Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. Our results show that recombination among natural isolates of this species is a common phenomenon, as 20 of the 31 isolates contained at least one locus in which recombination was revealed by at least three different methods. norepinephrine, dopamine and serotonin) to the pathophysiology of this disorder. Critical coupling control of a microresonator by laser amplitude modulation. Coral reefs are vulnerable to ultraviolet radiation (UVR, 280-400nm). In vitro experiments aimed at evaluating how the capacity of the nanocarriers to transfect siRNA in L929 cells was affected by MAA content. Since many people who suffer from micronutrient deficiencies are dependent on staple crops to meet their dietary requirements, the development of crop cultivars with increased levels of micronutrients in their edible parts is becoming increasingly recognized as a sustainable solution. Physiologic differences between men and women affect drug activity, including pharmacokinetics and pharmacodynamics. Functional anatomy of the cartilage of the distal phalanx and digital cushion in the equine foot and a hemodynamic flow hypothesis of energy dissipation. Inhibition of Rho kinase (ROCK) is an attractive strategy for the treatment of diseases such as hypertension, glaucoma, and cancer.

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Platelet aggregation plays a central role in the pathophysiology of acute coronary syndromes, and the platelet glycoprotein IIb/IIIa receptor has been identified as the critical final mediator of this process. To elucidate the epidemiological relationships between ND outbreaks and genetic lineages, a portion of the F gene (535 bp) and the full-length HN gene (1922 bp) of recent Taiwanese NDVs isolated in 2002-2008 was amplified by reverse transcription (RT)-polymerase chain reaction (PCR) and sequenced. Autism spectrum disorder-associated biomarkers for case evaluation and management by clinical geneticists. Moreover, the discovery of a novel mutant with glycosynthase-like activity has made it possible to synthesize homogeneous glycoproteins with full-size natural N-glycans. The induction of Mxi1 by FOXO3a was specific to the Mxi1-SR alpha isoform and was mediated by three highly conserved FOXO binding sites within the first intron of the gene. Overall, these data suggest that proteins that interact with SHIP1 through Tyr(917) and Tyr(1020), such as DOK1 and SHC, are likely to be involved in the regulation of SHIP1 dependent migration. Eight studies reported no or minimal differences in cognitive performance in the two groups, but only one study reported better cognitive performance in the schizophrenia non-user group. Identification and sequencing of the groE operon and flanking genes of Lawsonia intracellularis: use in phylogeny.

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High density lipoproteins and kidney function: the friend turned foe?. The concept is already outlined by Aristotle in his Historia Animalium. This case illustrates a possible pitfall in confirming complete isolation of the PVs during AF. After initial studies in canine prostates and human prostatectomy specimens, clinical studies with the holmium:YAG laser showed no fluid absorption, appreciable blood loss, or complications, and voiding outcomes were improved immediately, similar to the result with transurethral resection of the prostate. Integration of ABI1 into the SLAC1/OST1 complex, however, prevented SLAC1 activation. ICCs computed from the combination of the SDTD/VG data were markedly reduced for both control and aphasic subjects as compared with the ICCs for the individual tasks. Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that has disseminated throughout Canadian hospitals and communities. We were able to achieve a two-fold reduction in the lower limit of quantification and a three-fold reduction in retention time utilizing the UHPLC method, while keeping the same sample extraction procedure and similar MS/MS methodology. Significantly increased lesion size by using the near-infrared photosensitizer 5,10,15,20-tetrakis (m-hydroxyphenyl)bacteriochlorin in interstitial photodynamic therapy of normal rat liver tissue. Immunobiological changes of in vivo glucocorticoid depleted male Swiss albino rats.

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The purpose of this experiment was to examine the effects of advance knowledge on the kinematics of one-handed catching. Intervention consisted of assessment of allergic environment with avoidance recommendations, institution of appropriate controller therapy and inhaler technique, education on asthma and asthma management, and expectations for asthma control. Further, siRNA-specific silencing of MT1-MMP and MT2-MMP ablates completely the ability of Snail1 to drive cancer cell BM invasion, induce angiogenesis, or trigger intravasation. Probably, linalool and cineole interfered with hydrogen bonding between GP1 molecules while limonene could have initiated a phase separation-mediated gelation, changing the gel morphology. Removal of this late Dll expression resulted in disruption of adult appendage patterning. Polymerase chain reaction and sequencing for HPV DNA detected HPV 16.

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An application of this atlas construction methodology to the study of corneal shape evolution with age is presented. Osseous hemangioma of the seventh cervical vertebra with osteoid formation mimicking metastasis: a case report. Among teens with provider recommendations, males, younger teens, and white teens were less likely to initiate vaccination, compared to peers. Our studies had indicated that optic disc vasculitis (ODV) is a distinct clinical entity. Torsion of the fallopian tube: progression of sonographic features.

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The aim of this study was to determine how the treatment needs and outcomes of polysubstance-using patients entering opioid-substitution treatment (OST) may be affected if the patient had a parent with substance-use problems. Heavily T2-weighted MR myelography vs CT myelography in spontaneous intracranial hypotension. To characterize the obesity phenotype(s) in patients with idiopathic intracranial hypertension (IIH). Gender differences in clinical manifestations of Brugada syndrome. Liver regeneration and recanalization time course following reversible portal vein embolization. The patch was then removed and the subjects were rescanned 2 h later. To assess the risk of new-onset asthma, LAIV recipients without history of wheezing were analyzed. Finally, treatment of neutrophils with the protein kinase A inhibitor H-89 prevented PGE2- and RO 20-1724-induced inhibition of cell apoptosis. This result suggests that policy options that improve patient safety may offer a new avenue for reducing malpractice pressure on physicians, at the same time that they improve clinical outcomes.

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Several components of the division apparatus have been identified in the past several years and we are beginning to appreciate the plastid division process at a mechanistic level. Under the optimized extracting method, EZW possessed robust effect in activating the estrogenic activity, but which did not alter the proliferation of cultured MCF-7 cells. aeruginosa PAO1, the cloned rulAB determinant on pJJK17 conferred a 30-fold increase in survival and a 200-fold increase in mutability following a UV-B dose of 1,900 J m(-2). Young children with persistent wheezing pose a diagnostic and therapeutical challenge to the pediatrician.We aimed to evaluate bacterial bronchial infection as a possible reason for non response to conventional asthma therapy, and to identify and characterise the predominant pathogens involved. In a population with severe asthma, moderate/severe rhinitis is a strong predictor for greater severity of asthma. Scope exists to develop gel-based fruit analogues wherein an appropriate hydrocolloid can be employed along with fruit juice/pulp. A comparative hydrobiological study of a few ponds of Barak Valley, Assam and their role as sustainable water resources. Transformation of Phomopsis viticola with the green fluorescent protein. To assess the 4-year outcomes of surgery versus nonoperative care. The present study using propensity score matching demonstrated that BBC did not impair outcomes of LR for CLM.

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Patient vulnerability has been identified therein as playing a major role in what medicine is like zantac generating healthcare-related AEs. Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: analysis of 13 patients. We have now studied the role of phosphatidylinositol phosphates in synaptic vesicle exocytosis using synaptosomes. In a single reaction, we interrogate a total of 25 pathogenic mutations distributed all around the whole mtDNA genome in a sample of patients suspected for mtDNA disease. Surgery decreased NK cytotoxicity per NK cell in both immune compartments, and only the combination of etodolac and propranolol significantly attenuated these effects. These findings indicate that both feline PD-1 and PD-L1 are expressed by resting lymphocytes and dendritic cells. A transmission dynamic model was used to estimate the long-term epidemiologic and economic consequences of quadrivalent HPV vaccination.

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We found that enolase unfolds through a highly reversible pathway, populating a stable intermediate species in a range of experimental conditions. Atropine administration strategy should be oriented for the most affected organ pathology in fenthion intoxication. Influence of Anthropogenic Disturbances on Stand Structural Complexity in Andean Temperate Forests: Implications for Managing Key Habitat for Biodiversity. We concluded recommendations for adequate vegetable intake are expected to improve diet quality among Japanese adults, especially for the group aged 20-39. Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases. The large-scale properties of the system are described in terms of continuum equations for filament and motor densities, polarization, and alignment tensor obtained by coarse-graining the Smoluchovski equation. Prostaglandin A1 (PGA1) increases heat shock element (HSE)-mediated transcription, thereby enhancing expression of HSE-bearing genes, including heat shock proteins. Evidence for multiple independent origins of trans-splicing in Metazoa. The two zinc finger sequences of Cys4-Cys4 are most related to the RING zinc-finger motif carrying a Cys3-His-Cys4. The coordinated actions of these principal processes result in the reconstruction of a normal bone and restoration of a structural unit.

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