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Amitrim (Amitriptyline)
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Amitrim

Amitrim is a medicine used for treating pain. You can take it: to treat nerve pain (neuralgia) and back pain. to help prevent migraine attacks. The FDA withdrew the drug in 2000 following reports that it increased the risk of heart problems. Doctors may still prescribe the drug, but only in rare cases when it is necessary.

Other names for this medication:
Abamax, Amiclozor, Amicon, Amimax, Amitin, Amitone, Amitop, Amitrac, Amitrol, Amitryn, Amitwix, Amize, Amizep, Amline, Amoten, Amsha, Amtipax, Amtran, Amypres, Anitryp, Aptric, Bluneel, Chlotrip, Cotrip, Crypton, Eptanol, Kamitrin, Latiln, Libotryp, Limbival, Mitrip, Mitryp, Psycomer, Raitrip, Relidep, Ronet, Sarotena, Sereval, Tridep, Trixide, Typlin, Zodep

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Also known as: Amitriptyline

Description

Amitrim target is the treatment of depression. Amitrim is acting by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. It is tricyclic antidepressant. Generic name of Amitrim is Amitriptyline. Amitrim is also known as Amitriptyline, Amitryptyline, Amidon, Amitryn, Tryptanol, Endep, Elatrol, Tryptizol, Trepiline, Laroxyl, Saroten, Triptyl, Amitrip. Brand names of Amitrim are Amitrim, Endep, Vanatrip.

Dosage

Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitrim dosage information

Overdose

If you overdose Amitrim and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Amitrim overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Amitrim if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amitrim if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amitrim is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amitrim is not approved for use by anyone younger than 12 years old.

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Effect of human growth hormone and thyroid stimulating hormone on fatty acid composition of serum lipids and blood glucose in hyper- and hypothyroidism. elegans with FA for 120 h showed that mutagenic activity decreased with time. Comparison of ethanol, pentobarbital, and phenobarbital using drug vs. In two patients with persistent bleeding requiring urgent surgery, scintigraphy located the bleeding site pre-operatively, while in five patients with negative scintigraphy bleeding settled spontaneously without operative intervention. Limb salvage was achieved in 67 per cent of the nontraumatic group and in 56 per cent of the traumatic group. During interphase, the proteasome is localized in the nucleus, i.e., in the nucleoplasm and along the nuclear membrane. Renography is helpful especially in patients with acute tubular necrosis after renal transplantation. Mature enveloped virions belonging to the herpes class were found in a concentrated, partially purified specimen of throat washings from a patient undergoing immunosuppressive therapy for prevention of renal homograft rejection.

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Evaluating comparisons between continuous epidural and intermittent bolus techniques for postoperative analgesia. Bloody CSF was discharged per lumbar puncture and glycerol was infused intravenously, but the ventricle became enlarged. The deduced amino acid sequences of PchH and PchI are similar to those of ATP binding cassette transport proteins with an export function. Branched chain keto acids declined within 60 min, the corresponding amino acids within 20 min or later. In addition, lipopolysaccharide at the same concentrations increased urinary prostaglandins and serum cytokines levels. Sulfadiazine was a potent inhibitor of the in vitro growth of Toxoplasma gondii, although it had little effect during the first 24 hr of treatment. Lempert endaural subcortical mastoidotympanectomy for the cure of chronic persistent suppurative otitis media.

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In a mixture of a 14 Kd protein and a noninteracting 1.7 Kd peptide, the distribution of mass peaks in the electrospray spectra was close to that expected from random modification of the estimated solvent accessible area for the two molecules. Trisomy 14 in hematologic disease is a rare finding and is almost exclusively associated with myeloid cell lineage. Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-. Since the incidence of sex chromatin was significantly lower in these cells after transformation, it is likely that the loss of sex chromatin reflects the loss of the inactive X-chromosome at an early stage following transformation. Treatment for these injuries should not be allowed to jeopardise the brain which is more susceptible to damage in these circumstances. Cathepsin B and prolyl endopeptidase activity in rat peritoneal and alveolar macrophages. Steroid use should be limited to 24 h with antibiotics reserved for patients with signs of bacterial infection. The additives included electrolytes (calcium gluconate, potassium phosphate and magnesium sulfate), vitamins (M.V.I., Solu B Forte, phytonadione, cyanocobalamin and folic acid), insulin and heparin sodium. It is characterized by early syzygies with lateral connection and navicular sporocysts with similar poles.

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Among the various nitrovasodilators commercially available, nitroglycerin represents a well known substance to headache experts because of its capability to provoke spontaneous-like migraine attacks in headache-free migrainous subjects. Pharmacological approaches to the study of tranquilizing agents. High-grade prostatic intraepithelial neoplasia as an exposure biomarker for prostate cancer chemoprevention research. A cohort of 227 children having attended the same day treatment facility during their childhood was followed-up in adult life. Results of an experimental study of the pharmacokinetics of polymyxin B sulfate. The effect of methylcholanthrene on the viscosity of paramecium. Cost-effectiveness analysis is a potentially powerful method for measuring the benefits to be achieved by expenditures of health care dollars.

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Adaptive regulation of sugar and amino acid transport by vertebrate intestine. This study indicated that the F/T ratio and free PSA could improve the specificity without impairing the sensitivity for detecting PCa in patients with 4-20 ng/ml of total PSA. Parenteral glucagon had no significant effect on serum ionized calcium or calcitonin concentrations. Stress strain data were fitted to a two-parameter exponential model. The cannula could be used repeatedly and functioned well for over 4 yr. The authors provide recommendations on AP diagnosis and treatment in chronic alcoholics. Pressures were recorded with the microcapillary infusion technique while the subjects were either supine, sitting, or standing.

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The results suggest that MP could attenuate down regulation of adrenoreceptors induced by long-term CA infusion. Quantitative vestibular function testing in elderly patients with dizziness. These models show that the patterns of shear-wave splitting observed in the Mariana and southern Andean systems may be caused by significant three-dimensional flow induced by along-strike variations in slab geometry. An evaluation of the data on over 210,000 urinary stone analyses from the area of the former DDR. Intussusception and lipoma of the small intestine associated with acute pancreatitis. We have found that TRP2 extracted from all cell lines show dopachrome tautomerase activity, although the activity levels in human malignant melanocytes are much lower than in mouse cells. Studies of cerebrospinal fluid pressure during hypothermia in intracranial surgery. Characteristics of animal reactions to drugs in radiation injuries. A previously unreported characteristic of this technique is its ability to maintain relative vertical alignment of anatomic landmarks as the defect is collapsed horizontally.

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Results of this study show that it should be possible to outline the content and means of informing general practitioners about how to screen in order to enable them to participate in the Alsatian pilot campaign for screening for breast cancer. Computer utilization for intravenous nutrition in surgical neonates preliminary report. The Gots test can also be used for the detection of enzymatic resistance to ampicillin and chloramphenicol. Myocardial infarct in a patient with a coronary artery thrombosis at the site of the myocardial bridge in unaffected heart vessels. A significant depression in the activity of these dipeptidases was observed which was further found to be dose dependent. Rapid diagnosis of respiratory syncytial virus and influenza A virus infections by immunofluorescence: experience with a simplified procedure for the preparation of cell smears from nasopharyngeal secretions. However, this damage does not occur in particles lacking DNA, indicating that it is DNA-mediated.

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Despite the continued rise in TSH and progressive increase in thyroid gland size with further treatment, thyroid ODC activity declined on the third day and remained at submaximal levels. The PM cross-sectional area was measured in each patient, as well as postoperative fractional shortening (FS) of the septolateral, anteroposterior and vertical dimensions of the left ventricle. This unique susceptibility of the IgG2b subclass represents therefore an easy means of identification and also offers a simple procedure for a preparation of F(ab)2 fragments from monoclonal IgG2b antibodies. Induction of tumors in the stomach and nervous system of the ACI/N rat by continuous oral administration of 1-methyl-3-acetyl-1-nitrosourea. Dissecting aneurysm of cerebral arteries in childhood and adolescence. The establishment of the etiologic diagnosis in this case, which was complicated by the presence of oculocutaneous and esophageal herpes simplex virus infection as well as focal pulmonary aspergillosis, required coordinated histopathologic and virological investigation. Most of the excised lymph nodes contained metastatic deposits of oncocytic cells identical to the tumour seen in the parotid. Sporadically encountered accessory adrenal cortical tissue however did not exhibit genotypic preferences. The resolution of these isomers is quite crucial, since one of the isomers is the impurity in a pharmaceutically active drug.

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The aim of this study was to assess the value of dual-phase Tc-99m MIBI scintigraphy compared with US in the detection of adenomatous or hyperplastic glands and in the surgical decision-making process for patients with a biochemical diagnosis of primary hyperparathyroid disease. Blood glucose and serum insulin rose further during dialysis, particularly with hypertonic (215 mmol of glucose/l) dialysis fluid and levels remained high for 6 h after the onset. Problems relating to vascular reconstruction in renal transplantation from a living donor. Current status of tests for antinuclear antibodies (ANA) in rheumatic diseases. It is concluded that the statistical data show a considerable decrease of recent operative mortality both compared to recent years and to percentages reported by other AA.

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A busy district general hospital in the South East Thames Valley area with changing availability of a dedicated trauma list. Acute effects of inhaled dichloromethane on the EEG and sensory-evoked potentials of Fischer-344 rats. Regarding tumor staging, a comparison is mandatory between minilaparoscopy, conventional laparoscopy in analgosedation performed by the gastroenterologist and laparoscopy in intubation anesthesia performed by the surgeon immediately before planned laparotomy. Telomerase activity was detected in these postcrisis cells, but was not detected prior to crisis. In four neurons, most dendrites had an abnormal appearance in the light microscope with increasing diameter of distal branches. Murine hepatocytes were encapsulated in specially designed multicomponent capsules formed by polyelectrolyte complexation of sodium alginate, cellulose sulphate and poly(methylene-co-guanidine) hydrochloride, the permeability of which has previously been characterised.

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Squamous cell carcinoma in esophageal remnant after 24 years: lessons learnt from esophageal bypass surgery. Cervical CT angiography comparing routine noncontrast and a late venous scan as masks for automated bone subtraction: feasibility study and examination of the influence of patient motion on image quality. Its widespread presence and extremely conserved structure indicate that it may play a vital role in cell metabolism. This treatment has several distinct advantages over traditional amalgam restorations, but it requires excellent isolation from salivary and moisture contamination. Ten participants were presented auditory stimuli every 20 s while asleep. The study described here emphasizes the current lack of effort by health care providers in hospitals and nursing homes to find a workable solution. These effects varied in relation to the nature of the substituting residue, pH, and direction of the reaction, i.e. The case demonstrates that cardiac hemolysis may be a good indicator of valve dysfunction.

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Pulmonary vascular impedance analysis of adaptation to chronically elevated blood flow in the awake dog. Aloctin A given intravenously significantly inhibited the development of Shay ulcers and indomethacin-induced gastric lesions in rats. Rutin, quercetin, sophoricoside, sophorabioside and genistein were found. leprae more rapidly than do other antileprosy drugs currently available. Myriocin, a new antifungal antibiotic from Myriococcum albomyces. No alteration in the ploidy distribution of megakaryocytes was noted after endotoxin treatment. Women who obtain repeat abortions: a study based on record linkage. An antibody capture radioimmunoassay was used to detect and select appropriate hybrids for propagation and cloning. Despite the extensive use of crash helmets, head injuries were still a common and severe form of injury how long does bystolic 20 mg stay in your system resulting from traffic accidents, indicating the need for improvement of safety standards of crash helmets. Tracheobronchial mucus is produced by mucous bronchial glands and goblet cells.

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Intravenous injection of the liquid component of such cements (monomeric methylmethacrylate) into six dogs produced a significant fall in blood pressure together with an increase in heart rate and cardiac output. Thermal gradients during varying body temperatures with particular reference to changes during the application of external cold in patients with noninfectious fevers. We now report a case of colloid carcinoma arising in an anal fistula because of its rarity and other interesting features. The CPI was found to be a tight-binding inhibitor of both papain and cathepsin L, with Ki values of 0.1 nM and 1 nM, respectively. A case of an adult with disulfiram-induced hepatitis is presented. As 8-OH-DPAT influences hippocampal ACh release by a postsynaptic action, this finding indicates that the host brain exerts a serotonergic influence on the grafted cholinergic neurons. The kinetics were followed in plasma and urine and evaluated by individual kinetic modelling as well as by a nonparametric population kinetic method.

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Intravenous immunoglobulin preparations: a comparative in vitro study of Fc mediated functions. Furthermore, the induction of leptin secretion may have an important impact on bodyweight gain in patients treated with atypical antipsychotics. High glycemic index starch promotes hypersecretion of insulin and higher body fat in rats without affecting insulin sensitivity. The other 4 surviving cases received early exchange transfusion and low dose heparin therapy. On the assumption that insulin plays some role in the synthesis of glucokinase, the possible association between the plasma insulin concentration and hepatic glucokinase activity in mice in which plasma glucose concentrations are similar is discussed. Longitudinal study of growth in bilateral cleft lip and palate, from infancy to adolescence. This interpretative scheme is then used for the attribution of fluorescence signals collected from a tetradecane spray in different environmental conditions. Eight of the dogs had been treated with various immunosuppressive drugs. However, ECE expression after incubation with vasoconstrictor was significantly increased by PE sera. The most effective compounds in suppression nephrotoxicity were D-, and L-methionine, methyl and ethyl L-methioninate, and allopurinol et zyloprim 300 mg oral tablet N-acetyl-D, L-methionine.

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Using the FASTLINK program for parametric linkage analysis, the polymorphism did not show significant linkage to migraine when tested in four migraine pedigrees composed of 116 individuals, 52 affected. Aorto-coronary bypass surgery in a patient with red cell autoantibody and small e antibody. Avian leukosis viruses of different subgroups and types isolated after passage of Rous sarcoma virus-Rous-associated virus-0 in cells from different ring-necked pheasant embryos. Structural models of the glomerular basement membrane (GBM) have been based solely on the localization of antigens in animal kidneys. In contrast, enalapril, an ACE inhibitor with low affinity for cardiac ACE, only prevents the increase in plasma ANG II. Value of antimyosin monoclonal antibody scintigraphy in the diagnosis of acute myocardial infarction. Moreover, Glu-tubulin is enriched in prophase centrosomal areas, and, from metaphase on, exclusively also in the centrioles. New AED trials rarely use clinically applicable measures of efficacy, and it is difficult to extrapolate the data from populations used in AED trials to the wider population of patients with epilepsy. For infants who are exclusively or nearly exclusively breast-fed, weekly oral administration of 2mg (or 25 microg/day) vitamin K after the initial 2 oral doses is justified at completion of breast-feeding. Reversal of dyskinesis by increased end diastolic segment length in ischaemic-reperfused myocardium.

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Lateral head x-ray films and dental study models were collected quarterly and landmarks representing boundaries of the nasal capsule were identified. Comparative bacteriological studies in diarrheal diseases with special reference to Campylobacter jejuni. No significant changes were found in any of the measurements taken at the different levels. Inhibitors of protein synthesis cause increased hexose transport in cultured human fibroblasts by a mechanism other than transporter translocation. Cytological and ultrastructural assessment of free crystals or precipitates associated with pseudoleukocytosis and pseudothrombocytosis in cryoglobulinemia. Disputable problems of the effect of sulfanilylurea derivatives in patients with diabetes is theophylline an antibiotic mellitus and perspectives on their use. In this study we have tested the hypothesis that this disturbance is associated with left ventricular hypertrophy (LVH) in dialysis patients. Lipolysis is reduced in obese subjects by a decreased secretion of catecholamines, growth hormone, adipsin and cachectin.

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Studies on the uronic acid-containing glycoproteins of Fusarium sp. Three cases from one kindred who suffer from dominant paroxysmal ataxia are described. The introduction of new protocols of immune suppression and especially the use of cyclosporine have led to a marked reduction of infective pathology in children receiving transplants. Lead detection in living plant tissue using a new histochemical method. LV systolic and diastolic performance were assessed at rest and during peak upright bicycle exercise by first-pass radionuclide ventriculography zyvox generic cost .

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In chronic experiments EEG coherence and conjugation of impulse activity were compared of neurones of the visual and sensorimotor areas of rabbits neocortex simultaneously recorded with the same electrodes. Soluble polypeptide 47 kDa is absent in the cerebral cortex and hippocampus. The mitochondrial and synaptic membranes of the hair cells appeared normal. NAD-linked lactate dehydrogenases specific for the D- and L-lactate have been demonstrated in a number of strains of unicellular cyanobacteria. A serological test for the diagnosis of Strongyloides antibodies in ex Far East Prisoners of War. Evidence that thyrotropin-releasing hormone (TRH) has prominent trophic effects on the motor system led to several negative therapeutic trials in amyotrophic lateral sclerosis, a disease of the motor system. In vivo and in vitro assays of immunocompetence in bronchogenic carcinoma. To address these questions we examined vesicle release from large numbers of individual synapses of hippocampal neurons between five and 13 days in culture. The hybrid plasmid pSD2 carrying genes R, A and J of phage lambda has been constructed on the basis of the plasmid RSF2124.

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Lesions were most severe in the liver, with numerous organisms adjacent to areas of hepatic necrosis. Starling-Landis concepts of formation of interstitial fluids are in agreement with measurements of calf volume in normal young women, in horizontal recumbency or after horizontal immersion. Kidney mitochondrial respiration in protein- and energy-malnourished rats. Frameworks for midwifery care in Great Britain: an exploration of quality assurance. EBNA, seen only in cultures that had received exogenous EBV, was detected between days 1 and 6 after addition of EBV, most frequently on day 3. Power spectral analysis of heart-rate variations improves assessment of diabetic cardiac autonomic neuropathy. L-deprenyl, a MAO-B inhibitor, is significantly more effective in reducing prolactin levels in migraineurs than in controls. Immunoregulatory role of milk mononuclear cells and cytokines during the involution of the mammary gland. Decreased pulmonary diffusing capacity of divers over a 6-year period. Studies of human immunodeficiency virus type 1 (HIV-1) infection have attempted to quantitate the viral load correlate it with the degree of immune deficiency.

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for the subunit chains of Fc(I) and Fc(II) were 25,300 and 20,300, respectively, as determined by analytical ultracentrifugation under dissociating conditions. The nitrite oxidation reaction required ascorbic acid and oxygen. The substituted pyrocatechols sodium (2,3-dihydroxy-4,6-di-tert-butyl-phenyl)-S-thiosulfate (InH1) and 3-(S-glutathionyl)-4,6-di-tert-butyl-pyrocatechol (InH2) effectively inhibited oxidation of o-phenyle-nediamine and tetramethylbenzidine (TMB) catalyzed by hemin or its complex with BSA (methemalbumin). Thoracotomy, with evacuation of the granulomas, is recommended, especially when the lesions are large, in order to prevent subsequent fibrosing mediastinitis with involvement of the contiguous structures, such as the superior vena cava, azygos vein, trachea, what is generic cymbalta called esophagus, and left atrium. An effect of the vital dye trypan red on approach-avoidance conflict. Stereological methods under light and electron microscopy have been used to study the ventricular myocardium of rats exhausted by swimming exercise.

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