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Amitrix (Amitriptyline)

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Amitrix is used to treat depression. Compared to other antidepressants, it has a higher risk of side effects, such as weight gain and drowsiness. Amitrix is a tricyclic antidepressant (TCA). It works on parts of the brain responsible for raising levels of certain chemicals, like serotonin and norepinephrine, to help improve your mood.

Other names for this medication:
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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitrix dosage information


If you overdose Amitrix and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Amitrix overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitrix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Amitrix if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amitrix if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amitrix is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amitrix is not approved for use by anyone younger than 12 years old.

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The prepatent period of four geographic strains of Schistosoma japonicum. Basal bone resorption was inhibited by immunosuppressant cyclosporin A or mizoribine, while immunomodulators lobenzarit and traxanox failed to inhibit basal bone resorption. Good reproducibility was found using the 133Xenon infusion method. The ill-defined tumor involved the right cerebellar peduncle, medulla oblongata and upper cervical spinal cord, and showed mixed proliferation of many ganglioid cells and atypical pilocytic astrocytes with necrotic areas. The authors present their experience regarding the importance of radical removal and histology for a better prognosis.

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Mannose-KDO, galactose-KDO, and glucose-KDO ratios of virulent gonococci exceeded those of avirulent organisms, except that the correlation for glucose was not quite so striking. Further characterisation of the 5-HT receptor mediating smooth muscle relaxation in rat oesophagus. Of the proposals before Congress, only one offers assurance that the good in the present system of care will not continue to be an enemy of the better system for the future. The majority of immune studies in the spinal cord-injured population have focused on lymphocytes. The paper chromatography of certain anthraquinones and their glycosides. Synthesis of herpes simplex virus, vaccinia virus, and adenovirus DNA in isolated HeLa cell nuclei. Diuresis in gout: effects of Evian therapy on uric acid clearance.

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Severe kidney failure during treatment with angiotensin-converting enzyme inhibitors. The possible involvement of multiple transmitter systems in benzodiazepine withdrawal symptomology is discussed. Four years earlier, she had a herpes zoster (HZ) infection involving the ophthalmic division of her left trigeminal nerve with subsequent postherpetic neuralgia that was treated with steroids. The recording of oxygen saturation of hemoglobin by a whole-blood orimeter and its application to clinical investigation. Consequently cancer screening and early diagnosis should be confined to those selected tumours which are not affected adversely by diagnostic methods. The viral genome is large and can accommodate multiple or large non-viral genes including the full-length dystrophin. The effects of electrolytes and sugars on the erythrocytes of the turtle, Chelydra serpentina. We have prepared a monoclonal antibody which recognises an antigenic determinant on D dimer, a specific fragment resulting from the degradation of crosslinked fibrin. A large set of social variables was factor-analyzed and the factors were correlated with both suicide and homicide rates and with changes in these rates.

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Experimental aortic autograft in the treatment of aortic regurgitation. Fibroblasts were cultured from biopsies of human healthy gingiva. Trypanosoma congolense: erythrocyte indices, plasma iron turnover and effects of treatment in infected cattle. Phytohemagglutinin, ferritin-conjugated phytohemagglutinin, and influenza virus were used as labeling agents since they can be seen by freeze-etching techniques and each reacts with a different site on the same glycoprotein molecule. The possibility that the new VT originated from the apical endocardial lead was suggested by the unusual morphology of the VT, which was similar to paced. Experimental data suggest that bile acids and trypsin are noxious to the oesophageal mucosa and that their damaging potential depends on pH. We have evaluated the results of carotid surgery in 252 patients of 75 years and over age (A group) including 281 interventions between June 1st 1985 and December 31st 1993. Moreover, using freeze-fracture technique, we failed to show junctional structures where these endothelial cells came into contact.

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This study used a phenomenological approach to explore the lived experience of rehabilitation students during their final placement and first year of practice. The 780 children recruited from ten primary schools had their throats swabbed on each reporting of pharyngitis. A case of small intestinal stasis after vagotomy successfully treated with urecholine. The effects of multiplicity of infection, cell phase, and time with caffeine. Accelerated method of determination of saccharolytic properties of microorganisms.

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By comparison, postpubertal administration of testosterone enanthate (5 micromol/kg sc once daily on days 80-94 of age) did not enhance the inducibility of CYP2B1 or its associated activities in prepubertally ovariectomized adult (136-day-old) rats administered phenobarbital (10 mg/kg/day on days 129-135 of age). Serological investigations of Chikungunya virus in the Republic of Guinea. A syndrome suggestive of adrenal failure appeared on the 10 th to 12 th day consisting of abdominal pain, hyperpyrexia, arterial hypotension, asthenia, altered consciousness. Small-magnitude (2-3 beats per minute) heart-rate responses can show sex differences if assessed with a psychophysiological approach in which temporally fine-grained methods are used to determine topographical differences. Magnetic resonance imaging of the upper extremity: advances in technique and application.

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Candida abscess of the thyroid in a patient with acute lymphocytic leukemia. Because the progestogen challenge test is cheap and easy to deal with, it can be done as a primary screening method in asymptomatic postmenopausal women. Two 2-week-old calves with pyrexia, diarrhea, and subsequent dehydration were treated symptomatically for 1 week, but without favorable response. 34 patients have undergone posterior vitrectomy with the usage of perfluoropropane C3F8 gas for providing internal tamponade. Data on the content of ecdysteroids in plant sources are given and the ecdysteroid biosynthesis and role in plants are discussed. The lack of a spin label-detectable phase transition in hibernating animals, therefore, is attributed to an increased content of lysoglycerophosphatides present in the phospholipids during hibernation.

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Enhanced host defense mechanisms with levamisole in suckling rats. Calcium and phosphorus metabolism and eggshell formation of hens fed different amounts of calcium. Comparison of prosthetic materials used for abdominal wall defects or hernias (an experimental study). Comparative analysis of prefrontal learning functions in rats, cats, and monkeys. Complex dysrhythmias most frequently encountered in pediatrics include sinus node dysfunction, chaotic atrial rhythm, atrial flutter, supraventricular tachycardia (including Wolff-Parkinson-White syndrome and junctional ectopic tachycardia), complete atrioventricular block (congenital and acquired), and ventricular dysrhythmias (premature ventricular contractions and ventricular tachycardia).

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From November 1993, 135 patients with haemorrhoids of III and IV degree have been recruited and grouped in 3 random groups: the patients of the I group have been subjected to closed hemorrhoidectomy (Ferguson and is variant according to Khubchandani), the patients of the II group have been subjected to the Milligan-Morgan operation and those the III group of the diathermy hemorrhoidectomy. On physical examination, no patient had a Hospital for Special Surgery score in the fair or poor range and all patients had regained normal stability in the coronal plane both at full extension and at 30 degrees of flexion. High concentrations of DA and E in the allantoic fluid after opening of the egg shell decline during the following 24 hr, which indicates that they are due to stress. The changes in plasma and tissue fluid volume following exercise. More than half the subjects ask for toothpastes with texts providing information. Posthematoma residua include decreased parenchymal density, focal atrophy, and ventricular enlargement. When major psychiatric syndromes were examined, only manic syndrome showed familial aggregation. All the patients were operated repeatedly at two stages: radical necrosequestrotomy, epidermatoplasty and tendoplasty were performed at stage I and bone autografting with immobilization with an does clomid come up in a drug test plaster bandage were performed at stage II. We discuss some epidemiological aspects and diagnostic difficulties resulting from a changing clinical pattern of the disease, and emphasize the need for streptococcal sore throat treatment and continuous secondary prophylaxis to prevent recurrences.

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Ultrastructural changes accompanying the aging of human diploid cells in culture. To study the correlation between a basic parameter of intraocular lens biocompatibility, hydrophilicity, and two clinical parameters, postoperative inflammation and anterior capsule opacification. Production of bovine rhodopsin by mammalian cell lines expressing cloned cDNA: spectrophotometry and celebrex 200 mg pfizer para que sirve subcellular localization. Integration of chronically ill and handicapped children in Sweden. In IDD patients, anxiety is usually accompanied by hyperactivity of the hyperglycemic hypothalamo-visceral axis. Pretreatment of macrophages with neuraminidase did not affect epimastigote uptake but reduced that of trypomastigotes. The results of the present study demonstrate that area 3b somatosensory cortical neurons and their axons are vertically organized in a manner similar to that reported for other sensory cortical areas.

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