Also known as: Amoxicillin
Amopen is one of the best forms of antibiotic available today. It is used to treat infections caused by certain bacteria, including: infections of the ear, nose, and throat (pneumonia, bronchitis); infections of the genitourinary tract; infections of the skin and skin structure; infections of the lower respiratory tract; gonorrhea, acute uncomplicated (ano-genital and urethral infections) in male and females.
Amopen is also used before some surgery or dental work to prevent infection. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amopen may also be used for other purposes not listed here.
Amopen acts by inhibiting the synthesis of bacterial cell wall and stopping the growth of bacteria.
Amopen is available in capsules.
Amopen is usually taken every 8 hours (three times a day). It can be taken with or without food.
The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The tablets and capsules should be swallowed whole and taken with a full glass of water.
Take Amopen exactly as directed. Do not take more or less Amopen or take it more often than prescribed by your doctor. Do not stop taking Amopen without talking to your doctor. To clear up your infection completely, continue taking Amopen for the full course of treatment even if you feel better in a few days. Stopping Amopen too soon may cause bacteria to become resistant to antibiotics.
Adults: 1 g PO once daily or 500 mg PO twice daily for 10 days. The American Heart Association (AHA) recommends extended-release Amopen as an alternative to penicillin V for rheumatic fever prophylaxis.
Infants, Children, and Adolescents: 25 mg/kg/dose (Max: 500 mg/dose) PO twice daily for 10 days is recommended by the Infectious Diseases Society of America (IDSA). Alternatively, 50 mg/kg/dose PO once daily (Max: 1 g/dose) for 10 days is recommended by The American Heart Association (AHA) as an alternative to penicillin V. For ear/nose/throat infections in general, the FDA-approved dosage is 20 mg/kg/day PO in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses every 12 hours (Max: 500 mg/dose) for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose) for severe infections.
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Amopen are not associated with significant clinical symptoms and do not require gastric emptying.
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Amopen.
Crystalluria, in some cases leading to renal failure, has also been reported after Amopen overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Amopen crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Amopen. Amopen may be removed from circulation by hemodialysis.
Generic: store at controlled room temperature (between 68 and 77 degrees F)
Amoxil: store at controlled room temperature (between 68 and 77 degrees F)
Moxatag: store at 77 degrees F; excursions permitted to 59-86 degrees F
Moxilin: store at controlled room temperature (between 68 and 77 degrees F)
Sumox: store at controlled room temperature (between 68 and 77 degrees F)
Trimox: store at controlled room temperature (between 68 and 77 degrees F)