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Aplenzin (Bupropion)
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Aplenzin

Aplenzin is used to treat depression and to prevent depression in patients with seasonal affective disorder (SAD), which is sometimes called winter depression. It is also used as part of a support program to help people stop smoking.

Other names for this medication:
Aplenzin, Budeprion, Bupdep, Bupraset, Bupron, Bupropion, Ession, Nicotex, Smoquit, Unidep, Zyban

Similar Products:
Motilium, Zocor, Sustiva, Valium, Theolair, Trandate, Elavil, Urispas, Lopid, Eldepryl

Also known as: Bupropion

Description

{name} SR is an antidepressant used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.

Dosage

Take Aplenzin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

You should not change your dose or stop using Aplenzin suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms.

Do not stop using Aplenzin suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Some people taking Aplenzin have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with bupropion.

This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion.

Store at room temperature away from moisture and heat.

Detailed Aplenzin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Store in the original container. Use within 7 weeks of first opening the bottle. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Aplenzin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Aplenzin SR if you are allergic to it, or if you have:

a seizure disorder; an eating disorder such as anorexia or bulimia; or if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use an MAO inhibitor within 14 days before or 14 days after you take Aplenzin SR. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take Aplenzin SR to treat more than one condition at a time. If you take this medicine for depression, do not also take Aplenzin SR to quit smoking.

Aplenzin SR may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Tell your doctor if you have ever had:

a head injury, seizures, or brain or spinal cord tumor; narrow-angle glaucoma; heart disease, high blood pressure, or a heart attack; diabetes; kidney or liver disease (especially cirrhosis); depression, bipolar disorder, or other mental illness; or if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. It is not known whether Aplenzin SR will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Aplenzin SR is not approved for use by anyone younger than 18 years old.

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The specific aspects of portal hemodynamics and surgical correction of liver cirrhosis complications in Cruveilhier-Baumgarten syndrome. The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures. Further analysis revealed expression of Vd1 and two distinct TCRg chains, Vg3 and Vg9, by the malignant cell clone. Natalizumab treatment in pediatric multiple sclerosis: a case report. Within the same distance range, there are clear differences in various grids. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Dissociation curve analysis was applied to determine if hypermethylation occurred in the promoter region flanking the GSTP1 gene, a well-documented epigenetic event among prostate cancer cells, in these plasma DNA samples. This finding implicates that any problems arising from integrating auditory and visual information must stem from higher processing stages in high-functioning adults with Autism Spectrum Disorder. In vivo effects of citric acid/zwitterionic surfactant cleansing solution on rabbit sinus mucosa.

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We concluded that the higher expression of Ki-67 in NMSC of patients with XP than of non-XP patients may reflect the growth and invasive capacity of these tumors in patients with XP. Inappropriate prescription of BZD is frequent in old age, probably indicating untreated depression in many cases. To reveal the function of E2A and HEB through the stage of pre-TCR expression and alleviate functional compensation between E2A and HEB, we use a double-conditional knockout model. The aim was to analyse clinicopathological findings in DLBCL showing an interfollicular pattern of proliferation to determine whether this type of lymphoma is a distinct entity of DLBCL. EXPRESSION OF E-CADHERIN AND WNT PATHWAY PROTEINS BETACATENIN, APC, TCF-4 AND SURVIVIN IN GASTRIC ADENOCARCINOMA: CLINICAL AND PATHOLOGICAL IMPLICATION. Initial skill assessment of the California Harmful Algae Risk Mapping (C-HARM) system. Mitochondrias are the main source of cellular energy, central regulators of cell death and the main source for reactive oxygen species. An evaluation of the advantages and disadvantages of each method suggested that individual analyses and the use of peptide mixtures should be favored as complementary techniques in the search for biomarkers in ocular diseases. The aim of this article is to assess evidence for the timing of brain injury associated with clinical encephalopathy in the fetus and newborn. An expression and purification system for the biosynthesis of adenosine receptor peptides for biophysical and structural characterization.

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Oxidation of cysteamine induced by gas-phase radicals from combustion smoke of poly (methyl methacrylate). Using the specialized PBD of Plk1 as an affinity capture agent, we performed a screen to define the mitotic Plk1-PBD interactome by mass spectrometry. The polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance, but the connection between these two features has been unclear. MR imaging-guided interventions are well established in routine patient care in many parts of the world. The results implicate the importance of parallel recovery of both sensory and motor systems in functional recovery after stroke. Clinical features and surgical outcome of a suprarenal mass detected before birth. For the validation, the questionnaires of the DASH, the Health Assessment Questionnaire (HAQ), the Medical Outcomes Study Short Form-36 (SF-36), and the Arthritis Impact Measurement Scale (AIMS2) were used. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells. Instead, herpesviruses have a complex mechanism of nuclear escape whereby nascent capsids bud at the inner nuclear membrane to form perinuclear virions that subsequently fuse with the outer nuclear membrane, releasing capsids into the cytosol.

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Our results provide a simple mechanistic explanation for one type of slow oscillation based on delayed inhibition, which may play an important role in the slow spindle oscillations occurring during sleep. To illustrate the applicability of this approach, we use a case study from a temperate forest understory where tree seedling abundances were monitored during a 9-year period at 40 permanent plots. The authors describe a patient who underwent a right pneumonectomy for removal of a bronchial carcinoid tumour. Suppression of Rad51 may be a novel lung cancer therapeutic modality to overcome drug resistance to gefitinib. Preload dependence of color M-mode Doppler flow propagation velocity in controls and in patients with left ventricular dysfunction. Classical methods have been recruited to determine the molecular function and the physiological relevance of G-protein-coupled receptors (GPCRs), including ligand-binding and signal transduction studies, pharmacological receptor profiling in tissues and the characterization of transgenic mouse models. In contrast, there was a significant drop in arterial load compliance mainly due to the elevated arterial blood pressure in methoxamine-treated rats. The data are inconclusive because of the inability of reproduce the cellular response in a replicate experiment. Patients with RP have difficulties in adjusting to their visual loss particularly with respect to health-care orientation, vocational environment, social environment, and extended family relationships.

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Gestational age-related reference values for amniotic fluid organic acids. The outstanding progress in the molecular basis of thyroid carcinoma offered the tool for the development of new drugs, mainly tyrosine-kinase inhibitor and inhibitors of proangiogenic factors, which are currently in phase II or III clinical trials with promising results (the so called targeted therapy). In October 2007, the Danish government and regions made an agreement comprising acute treatment of ovarian cancer (OC) patients. Our results revealed that the structural changes in group 1, which exhibits folding/transport defects and a complete deficiency of AGA activity, were generally large and located in the core region of the enzyme molecule. Although the specific correction factors measured here are valid only for the tunnel tested, the magnitude of the factors (up to two or more) suggests that the phenomena observed here should be considered when interpreting data from other tunnels. Mass spectrometric works on prolamins have rapidly evolved from the determination of the molecular masses of proteins to the proteomic approaches aimed to a large-scale protein identification and study of functional and regulatory aspects of proteins. The tetraglucamine-appended NCP (TG-NCP) exists as monocation in aqueous solution containing 6 mM sodium dodecyl sulfate (SDS) but exists as freebase to form aggregates in pure water. Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers. Since essential hypertension is a well-known risk factor for myocardial infarction, we hypothesized that TNFRSF4 could be a susceptibility gene for essential hypertension.

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Phylogenetic analysis showed that these receptors fall into a family of closely related GPCRs. Depression occurs in approximately one-third of patients during antiviral therapy and can lead to reduction in treatment dosage or discontinuation of treatment, thus reducing the likelihood of clearing HCV infection. IL-13 or IL-4 stimulation of the PMBCL cell line Karpas-1106P induced an inflammatory phenotype that resembles that of the HL cell line. Sonar performance predictions of reverberation in shallow water rely upon good estimates of the bottom-scattering strength. Our findings are confirmed by numerical analysis of two particular examples, the Toda and the Rossler models. Pharmacologic activation of T cells distal to the TCR complex had no effect on RhoH protein levels suggesting that early events during T-cell activation are required for RhoH protein degradation. Four cats/study group were euthanized on days 3, 5, and 7, and eyes were collected for light and electron microscopic evaluations. The methylenetetrahydrofolate dehydrogenase (MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. Optimizing dual-energy x-ray parameters for the ExacTrac clinical stereoscopic imaging system to enhance soft-tissue imaging. yoelii hyperimmune sera or anti-GST-PYC2 sera directed to the major merozoite surface protein (MSP-1) of this parasite enabled both BALB/cByJ mice and FcR gamma-chain-deficient mice to resist lethal P.

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Good agreement between the model predictions and other studies was found. CEA, CK-19, GA733.2, and MUC-1 show no diagnostic value as mRNA markers for the detection of micrometastases by the RT-PCR assay because they are expressed in the blood and lymph nodes of patients without cancer. Peripartum hysterectomy and arterial embolization for major obstetric hemorrhage: a 2-year nationwide cohort study in the Netherlands. However, this resulted in the destabilization of the beta-alpha-beta turn with the concomitant nucleation of another three-residue turn, alpha-beta-beta, which is stabilized by 11- and 15-membered bifurcated H bonds. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. Medication- and diagnosis-specific data were utilized to conduct post hoc confirmatory analyses of the risk estimates. In midline incisions closed with a single-layer running suture, the rate of wound complications is lower when a suture length to wound length ratio of at least 4 is accomplished with a short stitch length rather than with a long one. The relative sample size needed to detect the nitrate effect was compared for different summary measures of ST depression.

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Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. We evaluated the effects of various lupane triterpenes on B16 2F2 mouse melanoma cell differentiation and proliferation. To analyze the outcome of adjuvant chemoradiotherapy for patients with distal common bile duct (CBD) cancer who underwent curative surgery, and to identify the prognostic factors for these patients. In this nonrandomized prospective interventional case study, 287 eyes of 146 consecutive patients were monitored by online OCP before and after flap creation with the femtosecond laser. Here we review the individual phylogenetic distribution of these proteins in bacteria, and apply a new genomics method to determine their potential implication in pathogenicity. The attacks recurred monthly without clear triggers, and he recovered his normal clinical state between them.

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Immunization of cattle with nymphal Hyalomma anatolicum anatolicum extracts: effects on tick biology. In 16 HCC patients, surgically resected specimens including HCC and surrounding liver parenchyma were evaluated. Furthermore, the STAT site and the BMP responsive element (BMP-RE1) located in the proximal 260-bp region of the Hamp1 promoter are also indispensable for maximal activation of hepcidin transcription. Predictions of chromatographic retention indices of alkylphenols with support vector machines and multiple linear regression. Reduction in the levels of glycosylated alpha-dystroglycan by immunoblot was also identified in an affected Devon Rex cat.

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