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Arapres (Losartan)

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Arapres belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Arapres prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Arapres slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Angilock, Araten, Cartan, Cormac, Covance, Cozzar, Czartan, Faxiven, Hizaar, Hypozar, Klosartan, Lifezar, Loctenk, Loortan, Loplac, Losamet, Losap, Losapot, Losar, Losargamma, Losart, Losartan, Losartil, Losatrix, Losavik, Losazid, Lospre, Lostad, Lostan, Lozap, Lozatan, Medzar, Myotan, Nefrotal, Ocsaar, Sarlo, Sortal, Tanlozid, Tarnasol, Tensiohess, Zartan

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Also known as: Losartan


{name} (losartan) belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

{name} is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

{name} is also used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.


Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Arapres dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Arapres are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Arapres.

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Highly purified C-type particles from milk of NZB mice were ineffective in the transfer of Coombs positive hemolytic anemia and cryoglobulinemia to neonatal BALB/cHeA and NZC/B1 mice. Intraperitoneal injection of leptin (1.3 mg/kg) caused a significant increase in hypothalamic histamine release, however, its intracerebroventricular injection (10 microg/rat) did not cause any significant changes in the release. Two major subgroups were identified and 13 different antigen patterns were observed among the 130 serogroup 1 strains. In the homogametic male, BrdU and dT incorporation revealed no evidence of asynchronous replication between euchromatic bands in the ZZ pair. Histologic confirmation is necessary for a definitive diagnosis. Special attention was paid with regard to their effects on the maximum upstroke velocity (Vmax) of action potentials.

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Escherichia coli which infects and causes disease of the urinary tract expresses several adherence factors including type 1 and P fimbriae. EMAP II was localized to monocytes/macrophages with rather selective staining of a minor rat monocyte subpopulation of lymphoid tissues such as spleen, lymph nodes or follicles of the gut. The purpose of this study was to investigate the psychometric properties of the Arabic version of the CES-D. Sections of lung tissue from six Norwegian individuals (ie, individuals from a non-endemic population) acted as negative controls, and six Ethiopian tuberculosis cases acted as positive controls. Sorption in the condensed domains may be a cause for slow desorption, and reduced availability and toxicity with aging.

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Promotion of health by soy isoflavones: efficacy, benefit and safety concerns. The effects of natural-type human tumor necrosis factor (nh-TNF) on tumor endothelial cells of experimental brain tumors were investigated electron microscopically. The effect of chenodeoxycholic acid feeding on bile acid kinetics and fecal neutral steroid excretion in patients with hyperlipoproteinemia types II and IV. The attenuating effect of alcohol on the coronary occlusion was negated by sporadic drinking of large amounts of alcohol. Natural occurrence of the mycotoxin fusarochromanone, a metabolite of Fusarium equiseti, in cereal feed associated with tibial dyschondroplasia. Gluconeogenesis with various concentrations of lactate and fructose was studied. Women discussed breastfeeding support as related to place, people and timing. In states of calcium excess the stimulated protein output was decreased by both vitamin D3 and parathyroid hormone. Specific expression of a novel cell wall hydroxyproline-rich glycoprotein gene in lateral root initiation.

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Studies with appropriate control blood fractions show that cytotoxicity tests with whole blood provide results reflecting natural cell-mediated cytotoxicity. In particular for girls, height and weight both show cohort effects (at 9.25 years of age) when the raw data are used. Regulation of pancreatic function through the gastrointestinal tract. The use of erythropoietin alpha in programs of high-dose chemotherapy. Is volume of distribution at steady state a meaningful kinetic variable?. Unlike traditional narrative reviews, meta-analyses require explicit statement of the criteria for the review and hence highlight these difficulties. A major part of this evaluation involved assessing the capabilities of these systems for displaying computed radiography (CR) images for primary interpretation. Relation how long do valium pills take to work of enteroinsular hormones at birth to macrosomia and neonatal hypoglycemia in infants of diabetic mothers. Drug resistance in myeloma: mechanisms and approaches to circumvention. DP enhanced the antitumor effect of UFT significantly (P less than 0.05), and combination treatment with UFT and DP proved to be the most effective regimen for inhibiting growth of B16 melanoma.

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Night blindness and liver cirrhosis as late complications of jejunoileal bypass surgery for morbid obesity. The aneurysmal tissue and aortic valve were excised and reconstruction was achieved with a composite graft. Male physicians and female health and sexuality in 19th century English and American society. These findings indicate that not a genetic recombination que es el medicamento arcoxia 120 mg but a genetic reassortment may play an important role in the emergence of HV-IBDV. Epidermal cell differentiation in Arabidopsis determined by a Myb homolog, CPC. This formula should be useful in designing clinical trials with a heterogeneous patient population. Four anastomoses were retrieved following irretrievable occlusion and found to have myointimal hyperplasia at the function between the ePTFE graft and collar. Method of control in training therapy in patients with arteriosclerotic stenocardia. Methyl parathion and carbarly resistance in Chrysomela scripta and Coleomegilla maculata.

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The ability to identify patients with progressive disease is central to efficient management: permitting optimal deployment of adjunctive therapy and sparing the non-progressing majority the morbidity of aggressive therapy. haematobium isolated from the urines of children living in Tenegue, Office du Niger, Mali. The importance of wound infection in antibiotic failures in the therapy of postpartum endometritis. Integration of the overproduced bacteriophage T5 receptor protein in the outer membrane of Escherichia coli. Serum triiodothyronine determination with an radioimmunoassay kit. Results indicated that all affective states induced more immune fluctuations (regardless of the direction) than the neutral state. A possible association of Chlamydia pneumoniae infection and acute myocardial infarction in patients younger than 65 years of age.

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