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Arkamin (Clonidine)
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Arkamin

Arkamin is FDA-approved for treating high blood pressure. There is an extended-release tablet version that is used specifically for attention deficit-hyperactivity disorder (ADHD). Though there is less evidence for it, Arkamin may also be used to treat other conditions like hot sweats, nicotine dependence, opioid withdrawal, or tic disorder.

Other names for this medication:
Arkamin, Clodict, Clonidine, Jenloga

Similar Products:
Arava, Xeloda, Zyvox, Arimidex, Cardizem, Motrin, Abilify, Rulide, Biaxin, Abhigra

Also known as: Clonidine

Description

Clonidine transdermal is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk for heart attacks. These problems may be less likely to occur if the blood pressure is controlled.

Clonidine belongs to the class of medicines called antihypertensives. It works in the brain to change some of the nerve impulses. As a result, the blood vessels relax and blood passes through them more easily, which lowers blood pressure. When the blood pressure is lowered, the amount of blood and oxygen going to the heart is increased.

This medicine will not cure your high blood pressure, but it does help control it. Therefore, you must continue to use it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain clonidine. It may not be specific to Arkamin-TTS-3. Please read with care.

Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many patients feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

To use the skin patch:

Use this medicine exactly as directed by your doctor. It will work only if applied correctly. This medicine usually comes with patient instructions. Read them carefully before applying the patch. Wash your hands with soap and water before and after applying a patch. Do not touch your eyes until after you have washed your hands. Do not try to trim or cut the adhesive patch to adjust the dosage. Check with your doctor if you think the medicine is not working as it should. Gently wash the area of skin where you will apply the patch with soap and water. Rinse the skin completely and dry with a clean, dry tissue. Apply the patch right away after removing it from the pouch. Do not cut it into smaller pieces and do not touch the sticky surface of the patch. Apply the patch to a clean, dry, and intact skin area on your upper, outer arm or upper chest. Choose an area with little or no hair that is free of scars, cuts, or irritation. Avoid putting the patch on skin areas where it could be rubbed off by tight clothing. Press the patch firmly in place with your fingertips to make sure that the edges stick well. The patch should stay in place during showering, bathing, or swimming for a full 7 days. If the patch becomes loose, press the edges against the skin and cover the patch with one of the white adhesive covers that are included in the package. Apply a new patch if the first one becomes too loose or falls off. It is best to apply each patch to a different area of the skin to prevent skin irritation.

To help you remember to use your medicine, try to apply the patch at the same time and on the same day of the week.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For transdermal dosage form (patch): For high blood pressure: Adults—One patch applied once every 7 days. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath) followed by low blood pressure (feeling light-headed, fainting, drowsiness, cold feeling, slow heart rate, shallow breathing, weakness, or pinpoint pupils).

Storage

Store the patches at room temperature in a closed container, away from heat, moisture, and direct light.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

After removing a used patch, fold the patch in half with the sticky sides together. Make sure to dispose of it out of the reach of children and pets.

Detailed Arkamin-TTS dosage information

Side effects

The most common side effects associated with Arkamin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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This case is interesting from the pathogenic, nosologic and prognostic point of view. Bilirubin conjugation and excretion appear to be governed by hepatocellular mechanisms that are, for the most part, separate from the conjugation and excretion of bile acids. An evaluation of possible relationships between the preparation and content of acellular pertussis vaccines and their efficacy reveals that, in most instances, there is much more extensive variability in content and mode of preparation of these products than in their clinical efficacies. Plasma cortisol remained above the normal range for comparable clock times for 18 hr, but fell below 15 mug/100 ml after 12 hr. This skill consisted of combined supination and flexion of the paw to hold the food over the gap. After 8 years of evolution, we have been able to verify a valuable degree of functional capability of the reconstructed hand. Response thresholds of simultaneously recorded MLRs and ABRs, and latencies and amplitudes of MLR peaks were analyzed with respect to stimulus intensity (10-80 dB SPL) and frequency (0.5, 1, 2, 4, 8 and 16 kHz). suicide rates from 1990 through 1994 to determine whether regional variations in suicide rates are affected by differences in age, race/Hispanic-ethnicity, and sex and to examine whether method-specific rates varied by region.

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The importance of DNA methylation for stability of foreign DNA in barley. Expressed Emotion in families of chronic schizophrenics and its association with clinical measures. Development of differentiation between writing and drawing systems. Most of the results in this area, especially those related to di-ethylhexyl-phthalate, are collected from animal studies and the extrapolation to humans is still controversial and difficult. The first 22 MeV micron installation for radiation therapy is described with regard to the general design, the beam transport and the gantry. Although the chloroplast envelope is impermeable to pyridine nucleotides, illuminated chlrooplasts reduced added NAD via the malate shuttle in the absence of electron acceptors and also during the reduction of glycerate or CO2. The antigen-independent competition radioimmunoassay is specific and has 80-100 ng/ml-1 of HBsAg sensitivity. A total of 84 predicted protein-coding genes including 7 genes duplicated in the inverted repeat regions, 4 ribosomal RNA genes and 37 tRNA genes (30 gene species) representing 20 amino acids species were assigned on the genome based on similarity to genes previously identified in other chloroplasts. Fluorescence spectra of DNA isolated from hamster embryo cells incubated with 7,12-dimethylbenz(a)anthracene, or DNA modified in a microsomal system by reaction with this carcinogen or its 7-hydroxymethyl derivative, were compared to various model compounds. Increase in free fatty acids and triglycerides, decrease in cholesterol concentration in serum characterised the anuric phase.

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Role of the adrenal cortex in adapatation of intestinal absorption. Moreover, vertical control of the lower anterior facial height in open bite growth patterns was observed in the sample investigated. Dr Nathwani et al: Adult Presentation of X-Linked Hypogammaglobulinaemia. Endoscopic sinus surgery was successfully used to treat this case. With the advent of the AIDS epidemic, it has made a comeback and often in a form more virulent than was seen in the past. Chemical modification of functional arginyl residues in beef kidney D-aspartate oxidase. Two types of neuronal cytosomes were discribed: lamellar concentric bodies, resembling membranous cytoplasmic bodies, and polymorphous complex bodies, unit membrane bound including various material, mostly resembling lipofuscin.

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Indirect complementation of a nontransforming mutant of polyoma virus. Use of poly-beta-oxybutyric acid by Yersinia pseudotuberculosis and Listeria monocytegenes bacteria at various temperatures. Nevertheless, several lines of evidence point towards adhesive phenomena as mediating some crucial steps in the malignant spread of particular tumour types. Previous studies have not focused on the role of environmental tobacco smoke (ETS) as it relates to tobacco hypersensitivity (TH) in nonsmoking children. There were no significant increases in the IL-6 content in the hypothalamus, medulla oblongata, and cortex of the brain after intravenous IL-1 beta. However, the risks of using kidneys from HBsAg-negative but hepatitis B core antibody (HBcAb)-positive donors have not been defined. Effect of immunological differences on rat aortic valve allograft calcification. Odontogenic myxoma - clinical concept and morphological studies.

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The forces found were compared with corresponding EMG-activity of muscles. Despite this correlation, no SDS--polyacrylamide band migrating at p28 was observed in purified intracytoplasmic A particles. The work of the EULAR Standing Committee on International Clinical Studies Including Therapeutic Trials (ESCISIT). Cause and pathogenesis span a continuum from organic to psychogenic and most often include a mosaic of factors. We also demonstrate that the application of anisotropic diffusion leads to more consistent and reproducible visual extraction of features from portal images. All of the subjects underwent the same Fukuda-Unterberger experimental stepping test to check their postural attitude.

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Chemistry and pharmacology of homologs of 6-acetyl-and 3,6-diacetylmorphine. Abnormal sensitivity to erythropoietin in the erythroblast precursors in Vaquez disease. The importance of multivariate statistical procedures in the diagnosis of acute radiation injuries in man. When the dose-response function was redetermined at 36 h post-chronic treatment, it was found that the function had shifted to the right, indicating tolerance. In a few of the animals there was a marked increase in SP-immunoreactive nerves (lacking CGRP), most conspicuous in the duodenal portion, both 4 and 40 weeks after transplantation probably secondary to a chronic pancreatitis. The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition. The mixed anhydride of ADP and mesitylenecarboxylic acid inhibits the ATPase activity of submitochondrial particles and has no effect on the activity of soluble mitochondrial ATPase. Fortunately, serotonin syndrome was recognized early, the offending agents were discontinued, and supportive treatment was provided.

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The probable relationship between the toxicity of Dinophysis and the synthesis of the new protein by mussels prompted us to produce a monoclonal antibody against this protein because it should be useful for the identification of mussel toxicity. Reproductive cycles of the talapoin monkey (Miopithecus talapoin). Integrons are genetic elements that acquire and exchange exogenous DNA, known as gene cassettes, by a site-specific recombination mechanism. 3H-fucose incorporation into glycoproteins of toad bladder epithelial cells. Vitamin E treatment inhibited the increase in lipid peroxide level totally in the heart and partially in the soleus, with minimal changes in the other biochemical indices studied. The optimal dose of hyperbaric tetracaine spinal anesthesia for cesarean section. This study is based on the 1983 Rural Health Survey of Ethiopia. Cereal grain dusts as a cause of respiratory allergy in South Africa. Aspiration of the contents of the hernia led to complete resolution of the physical signs.

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Standardization of the cytological conclusions in the diagnosis of cancer of the lung, stomach, breast and thyroid gland. Histopathological variations in the vitelline duct in heterotopic gastric mucosa with special reference to inflammatory changes. Although all treatment regimens caused some reduction in the 24-h excretion of corticosteroid products, none of the mean values was below the normal ranges. Comparison of the effectiveness of a phytogenic preparation with two new ointments containing synthetic drugs. A computer program using a nested analysis of variance in morphometric sampling. Effects of respiratory viruses on pulmonary alveolar macrophages. Myopathy and myoglobinuria occurred in a group of feedlot cattle in Alberta following transportation. Ethanol-induced skeletal muscle myopathy: biochemical and histochemical measurements on type I and type II fibre-rich muscles in the young rat. In vitro experiments demonstrated that SgI/ChmB effectively promoted cell-substratum adhesion of NIH 3T3 and PC12 cells and supported neurite outgrowth in primary hippocampal neurons. Pluronic L-81 is a hydrophobic surfactant which blocks intestinal chylomicron secretion at the pre-Golgi level without affecting triacylglycerol uptake and re-esterification.

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Adrenomedullin (ADM), acting through ADM(22-52)-sensitive receptors, is involved in the endotoxin-induced hypotension in rats. The large rise in cyclic AMP accumulation at 5 minutes due to 1.5 muM norepinephrine in the presence of 100 muM theophylline was only slightly inhibited by 0.05 or 0.1 mg/ml of tetracycline. The amino acid sequence of the polypeptide segment which regulates membrane adhesion (grana stacking) in chloroplasts. The spinal cord in neurologically stable spina bifida: a clinical and MRI study. The average graft survival time in this series was 28 days, significantly less than the 71 days in the first series. Instead, the pretectum projects directly to visuomotor, visceromotor and arousal systems. Submicroscopic localization acetylcholinesterase in synapses of the caudal mesenteric ganglion in cats. They report the various clinical manifestations resembling fat embolism, the free interval and general signs, pulmonary, neurological, hematological and dermatological symptoms associated with inconstant laboratory abnormalities which permit one to suggest a complex pathogenesis: --Immuno-allergic (early shock due to circulating antibodies). The mandible, temporomandibular joint, zygomatic arch and temporal region were reconstructed by means of skull bone grafts when the patient was 6 years old, a relatively early age. These results indicate that the acyl-DAla termini of membranes-associated spin-labeled undecaprenyl-diphosphate-MurNAc-pentapeptide are accessible to vancomycin and ristocetin and that the association constants are smaller than those determined for the corresponding antibiotic spin-labeled UDP-MurNAc-pentapeptide complexes.

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In SRS, the protein-protein interactions take place in the cytoplasm instead of the nucleus, as is the case in the conventional two-hybrid system. The effect of ouabain on cardiac performance in experimental hemorrhagic shock. Available information suggests that both humoral and cellular immunity are involved in protection. A case of colon cancer with tension pneumothorax and empyema as a consequence of colo-pleural fistula. Ultraviolet laser-induced fluorescence of human stomach tissues: detection of cancer tissues by imaging techniques. This chapter discusses empirical research and psychological theory bearing on the effects of coercion and choice and suggest ways that clinicians can apply the law more effectively in mandatory treatment contexts. Specific receptors for pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide with neuroregulatory and neurotrophic functions, have recently been identified in the retinas of different mammalian species. A gene coding for the major histocompatibility antigen HLA-A2 was transferred into human HLA-A2 negative M1 cells and murine L cells. Effects of azepexole on blood pressure, pulse rate, plasma renin activity and urinary catecholamines in normotensive subjects. Group 4 received cisplatin 8 mg/kg and group 5 received cisplatin 8 mg/kg plus D-met.

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We have purified a novel immunoregulatory factor (BMPG: bone-marrow proteoglycan) produced by a T-cell hybridoma, with a monoclonal antibody column. None of these contaminants was clearly linked to increased incidence of abortion in the studies reviewed. The anticoagulant effect of heparin is in relation with the presence of sufficient amounts of ATIII. We studied the presence of estrogen receptors (ER), progesterone receptors (PR) and the stress-responsive protein of 27K (srp27, a protein first described as an estrogen-induced 24K protein in MCF-7 cells) in both normal stroma and stromal sarcoma. Determination of the concentration of the cardioprotective drug cardiochrome in the plasma of patients. Endovascular treatment of a noninfected anastomotic juxtarenal aortic aneurysm. Activation of pyruvate dehydrogenase in adipose tissue by insulin. Lactation inhibition by the early postpartum administration of Methylergobrevin. According to the positive reaction for cholinesterase as well as the characteristics of the synaptic vesicles, these structure have at least a double adrenergic-cholinergic innervation.

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The emergence of lightweight rowing as an international sport has made the optimization of physique within the weight restrictions a matter of primary importance in selection and training of the participants. The mixed backbone oligonucleotide (ON) (or gapmer) approach, in which a short internal window of RNAse H-competent residues is embedded within an RNase H-incompetent ON has not been how much is plavix 75 mg applied previously to PNA because PNA and DNA hybridize to RNA with very different helical structures, creating structural perturbations at the two PNA-DNA junctions. The role of modeling in prevention and extinction of phobic behaviour in cynomolgus monkeys (Macaca fascicularis). The results suggest that transcription of the viral genome in SV40-transformed cells is cell-cycle-dependent. A 5-year old Arabian mare fell during recovery from general anesthesia after an exploratory laparotomy. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations. Significance of 20 minute resting blood pressure measurement comparing to 24 hour ambulatory blood pressure monitoring. Though their number was reduced, most of the spermatogonia appeared unaltered.

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Interactions between the two extended parts of the peptide were not observed, thus excluding the existence of a beta-sheet. Brain abscess in renal transplant recipients: report of three cases. In the present paper we analyze the effect of CO2 laser in the mouse tongue, in relation with the intensity and exposition time. Antihypertensive mechanism of diuretic treatment with chlorthalidone. In cellular systems provided with activatory (Ra-site) receptors for adenosine, such as rat cerebral microvessels and rat liver plasma membranes, the adenosine-receptor antagonist 8-phenyltheophylline (10 microM) significantly decreased adenylate cyclase activity if ATP was the substrate and only if GTP was present. The can you take zyrtec while drinking alcohol primary goals of therapy for brucellosis are to improve the symptoms, reduce complications and prevent relapses. The influence of oxygen tension on the respiratory rate in different segments of onion roots. Forearm arterial injury usually does not lead to acute ischemia, but a functional deficit may develop. Conversely avarone appeared to interfere mainly with the initiation phase of lipid peroxidation. Intraperitoneal injection of endotoxin resulted in bronchial hyperreactivity to histamine in guinea pigs.

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Genome profiling, which employs temperature-gradient gel electrophoresis (TGGE) for DNA analysis, has recently been developed in identifying species by genotype. Greater satisfaction was noted in regard to accessibility of the doctors. Protoplast transformation of Bacillus stearothermophilus NUB36 by plasmid DNA. Immunologic changes in the acute and chronic idiopathic thrombocytopenic purpuras in the child. To evaluate the acceptance and effectiveness of 0.2 mg x kg(-1) of oral transmucosal midazolam as a premedicant in infants and preschool children. F1-ATPase isolated from rat liver mitochondria has been found to contain approximately 1 mole of FAD and 6 g atoms of nonheme iron per mole of enzyme. Metoclopramide, a procainamide derivative with a documented effect on the gastro-intestinal motility, was given to four patients with hydroureter. Completion of the replication and division cycle in temperature-sensitive DNA initiation mutants of Bacillus subtilis 168 at the non-permissive temperature. In case of neonatal hypoglycemia, the criteria leading to the diagnosis of hyperinsulinism, i.e. Production of interferon in the murine mixed lymphocyte culture.

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The findings represent an unusual type of cerebral vasculitis whose etiology and pathogenesis are unknown. Similar to human B cells, binding of murine B lymphocytes by VH4-34-derived anti-i CA mAbs leads to rapid cytotoxicity of target cells as tested both in vitro and in vivo. Idiotype-bearing lymphocytes in the peripheral blood of patients with monoclonal gammopathy. Each subject received one dose of each treatment separated by a washout period of at least 2 weeks. The dosage regimen of levamisole in cancer: is it related to efficacy and safety?. Efforts at lowering the fetal death rate must be directed to those conditions affecting the fetus during labor or immediately afterward. Production of breaks in single- and double-stranded forms of bacteriophage phi X174 DNA by proflavine and light treatment. Practical applications of the distinctive pattern of mucin secretion are discussed.

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Pneumoperitoneum and pneumomediastinum in a CAPD patient with peritonitis. By combining protein chemistry to chromatography and mass spectrometry, the telokin heterogeneity was analyzed. Mutagenicity and carcinogenicity correlations between bacteria and rodents. The ssDNA binding site involves the helicase motifs Ia, III, and V, whereas the ADP binding site involves helicase motifs I and IV. Progesterone induction of the uterine milk proteins (UTMP), the major secretory products of the ovine uterus during pregnancy, was studied in ovariectomized ewes given physiological levels of progesterone for 0, 2, 6, 14, or 30 days. No pontine lesions were present in 15 of 20 patients in whom the diagnosis of CPM had initially been made. Hence, it seems likely that lack of VH alone is not sufficient to explain the failure of assembly observed in muHCD.

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Immunological studies of human trophoblast: markers, subsets and functions. To enhance utility of the linear epitope mapping (Pepscan) technique for assay of humoral responses linked to vaccination, two modifications were tested. Forty-eight pregnant Black patients with overt diabetes were treated with a protocol of strict control of plasma glucose levels. The occuring shifts are of bilateral character in different periods of the chemical effect, but in most cases a decrease in the copper content in the tissues under study is dominating. Administration of platinum analogues in combination is an alternative dose-intensification strategy that has been little studied. Twenty-five lacrimal systems of 17 patients, who presented with unilateral or bilateral epiphora and no concurrent ocular or lid abnormality, were prospectively entered into the study.

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Measuring the value of the grey scale median is a quantitative way of assessing the degree of organisation of a deep vein thrombosis. The bursting pressures with EnSeal were significantly higher than with all the other instruments. Chemical synthesis and cloning of a poly(arginine)-coding gene fragment designed to aid polypeptide purification. Incompatibility of phosphate buffer in 99m Tc-sulfur colloid containing aluminum ion. At these visits, contour of lid, condition of wound, cornea and donor site were examined for infection, dehiscence, corneal ulcer, notching, trichiasis, and recurrence. These inversions move the nucleolus organizer to the distal end of the X chromosome. Steady-state RNA and protein levels and consequently, the enzyme activity of GSA-AT were reduced in plants expressing ALA-S. A legal and ethical consensus is emerging that preembryos are not legal persons or moral subjects, although they are owed special respect because of their ability to implant and come to term. At several fluences (doses), a linear relationship was observed between the phenylalanine gradient and the combined electrical and chemical potentials (the electrochemical proton gradient), suggesting a close coupling between them. Thus, an initial interaction between T3 and specific cytosol proteins does not appear to be a prerequisite for translocation of T3 to nuclear sites.

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