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Asivol (Nebivolol)
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Asivol

Asivol is indicated for the treatment of essential hypertension (no age limit), and for stable chronic heart failure in combination with conventional therapies for patients aged 70 or older. It works by blocking the beta1 adrenergic receptor, and has mild vasodilatory properties mediated through nitric oxide release.

Other names for this medication:
Amlopres, Amlovas, Asivol, Betalol, Bivol, Ebivol, Hypoloc, Lobivon, Lovispes, Nebest, Nebicard, Nebicip, Nebicur, Nebilet, Nebiloc, Nebilol, Nebilong, Nebimac, Nebinex, Nebinorm, Nebipil, Nebipril, Nebispes, Nebistar, Nebiten, Nebitime, Nebivas, Nebivolol, Nebivololum, Nevol, Niavas, Nodon, Nubeta, Zenebi

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Bystolic, Deltasone, Mysoline, Ativan, Mircette

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Also known as: Nebivolol

Description

{name} (nebivolol) belongs to a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

{name} is used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack.

{name} may also be used for other purposes not listed in this medication guide.

Dosage

Take Asivol exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Asivol at the same time every day. You may take the medication with or without food.

Do not skip doses or stop taking Asivol without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems such as severe chest pain or heart attack. You may need to use less and less before you stop the medication completely.

Your blood pressure will need to be checked often. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using Asivol.

Asivol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Keep using Asivol as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store Asivol at room temperature away from moisture and heat.

Detailed Asivol dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include slow heart rate, dizziness, vomiting, trouble breathing, or feeling like you might pass out.

Storage

Store at a room temperature between 4 and 30 degrees C (39 and 86 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Asivol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

To make sure you can safely take Asivol, tell your doctor if you have any of these other conditions:

severe liver disease; or a heart problem such as heart block, sick sinus syndrome, slow heart rate, or heart failure.

If you have any of these other conditions, you may need a Asivol dose adjustment or special tests:

asthma, bronchitis, emphysema; liver or kidney disease; diabetes; a thyroid disorder; a history of allergies; problems with circulation (such as Raynaud's syndrome); pheochromocytoma (tumor of the adrenal gland); or if you have recently had a heart attack.

FDA pregnancy category C. It is not known whether Asivol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Asivol. It is not known whether nebivolol passes into breast milk or if it could harm a nursing baby. Do not use Asivol without telling your doctor if you are breast-feeding a baby.

Asivol pregnancy and breastfeeding warnings (more detail)

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Shortening the length of the protease inhibitors from hexapeptides to tripeptides revealed that the decrease in potency was much less when determined in the assay system with the full-length NS3 protein. Continuing research: the modification of defenses in psychoanalysis. These data suggested that ULN was almost all fragmented, consisted mainly of N-terminal domain of the B2 chain, and was suspected of a tumour-associated protein fragments probably derived from basement membrane degraded proteolytically by tumour cells. A large glycoprotein of Moloney leukemia virus derived from interferon-treated cells. Pathology revealed a glomus tumor, which is extremely rare in the para-Achilles tendon area. This suggests that extensive microenvironmental influences may be involved in CSF-mediated granulopoiesis. Plasma prolactin levels and ovarian responsiveness to exogenous gonadotropins. Effects of glucose consumption, clofibrate administration, and alcoholic fatty liver. We have developed five computer programs that automate analysis and classification of potential amphipathic helical domains from primary amino acid sequence data.

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Characteristics of an established cell line of amniotic epithelium. The distance at which the cationic electrolyte changes its effect from positive to negative is termed the critical separation distance in this paper. Echocardiographic appearance of an iatrogenic mediastinal hematoma. Except for the visual N1, early component amplitudes did not change significantly over this age range. Progenitor cells isolated from postconfluent cultures of cerebellum, however, develop rapidly into oligodendrocytes when grown in a serum-free medium. The program is more user-friendly than other comparable speciation programs, can write the results files in formats suitable for importing into other programs, and, in many instances gives results faster than speciation programs running on microcomputers. Anaerobes were cultured from 70 intra-uterine swabs and from 56 products of conception. These results are congruent with a series of recent polarity-specific findings.

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This report reviews the outcomes of patients on mechanical ventilation admitted to a new regional weaning center. Changes of succinic dehydrogenase, adenosinetriphosphatase, alkaline and acid phosphatase in rat kidney, during 6 months after a whole-body 800 r X-ray exposure were studied. Plasma electrolytes in hypertension produced by renal compression. Moreover, some researchers are urging higher doses for the entire population to prevent osteoporotic fractures. Here, we have investigated the mechanism of action responsible for the differential sensitivity of malignant versus non-malignant pancreatic cells to the drug.

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In-vitro study of the sensitivity of 200 strains of Neisseria gonorrhoeae to 7 antibiotics. dGTP levels increased as did dTTP levels in all cells, while dATP pool expansion correlated with thymidine sensitivity. The effects of insulin and hyperglycemia on surfactant phospholipid synthesis in organotypic cultures of type II pneumocytes. Delayed onset of HIT might be related to delayed metabolism of heparin due to postoperative fluid shift. Although these inhibitors prevented germ tube emergence at concentrations of 1 microgram/ml and 20 mM, respectively, neither significantly affected cell viability as judged by trypan blue staining or the rate of protein biosynthesis throughout the time course of the experiments. Primary B cell mediastinal lymphoma has been recognized as a distinct entity recently.

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Magnetocardiograms and their variation over the chest in normal subjects. A comparison of this test with alternate detection procedures shows excellent agreement at comparable sensitivity levels. The effects of size, time of day and sequence of meal ingestion were determined in healthy subjects using a Latin square design. The rat aorta was depolarized by KCl (20 mM), noradrenaline (0.3 microM) and 5-hydroxytryptamine (1 microM). Sweep frequency threshold measures were obtained using a pressure-tight probe transducer driven by a Bekesy automatic audiometer. The diagnosis was made on the association of a mediastinal mass behind vertebral malformation in five cases. ESR study of aqueous dispersions of beta-lactoglobulin and spin-labelled glyceryl monostearate. The three other manufacturers provided eight Mueller-Hinton agars that were satisfactory for the preparation of HTM agar, provided that small zones of inhibition with cefaclor, cefuroxime, and cefamandole disks are accepted as the preferred result.

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A new mucolipidosis with psychomotor retardation, corneal clouding, and retinal degeneration. Hydatidosis: epidemiological study in the eastern region of the province of Formosa. Feasibility of suppressing and reinitiating lactation in women with premature infants. The relationship between patient-staff ratio and reported patient incidents. Studies of physico-chemical properties and structure of aluminum hydrochloride obtained from aluminum isopropanolane. Effective method of simultaneous extraction from the urine and purification of tissue kallikrein and acid-stable trypsin inhibitor.

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For the 8 test allergens most often found positive (nickel, fragrance-mix, cobalt, chromate, balsam of Peru, carba-mix, colophony, and formaldehyde), one or more individual factors were of significance for the risk of being sensitized, except for chromate and formaldehyde. Clinico-pathological study of elderly women with malignant ovarian tumors. Identification of ligand binding determinants of the prolactin receptor. Use of covalently bound cord factor analog to increase tumor immunogenicity. The pattern of DEX inhibition of differentiation was similar in the two lines. It is possible that the growth response of the prostate may be influenced by enzymes that form or metabolize dihydrotestosterone and also by cytoplasmic receptors. There were no sex differences in the cortical pathology of lesioned animals.

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Letter: Intracellular cyclic AMP levels and radiosensitivity in synchronized V-79 cells. The patient did not consent to chemotherapy, and instead was given oral prednisolone. At optimum concentrations, absorbance values from immune and nonimmune sera produced sample to noise (S/N) ratios three-fold higher for the column antigen than for XM-300. Troglitazone (CS-045) ameliorates albuminuria in streptozotocin-induced diabetic rats. The loss of binding upon deletion of specific DNA segments localizes the boundaries of protein/DNA interaction sites. The paper shows the informative value of a tremor signal to detect abnormalities in the formation of the neuromuscular system. Determination of the DNA sugar pucker using 13C NMR spectroscopy.

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We now report the results of in vitro hepatocyte uptake studies with alpha 1-proteinase inhibitor-trypsin complexes. To evaluate the factors responsible for the accumulation of indium-111 immunoglobulin G (111In-IgG) at sites of inflammation, sequential measurements of tissue blood volume, interstitial fluid volume and accumulation of radiolabelled albumin and IgG were made in rats following Escherichia coli infection in the thigh. We sought to determine the effects of continuous positive airway pressure (CPAP) on mitral regurgitant fraction (MRF) and plasma atrial natriuretic peptide (ANP) concentration in patients with congestive heart failure (CHF). Urine biotin excretion at 102 d was significantly lower for the unsupplemented pigs than for the pigs given various levels of dietary biotin supplements. Influence of diltiazem on postischemic microcirculation and function in the rat kidney. Graded small intestinal ischemia was induced in cats by partial occlusion of the superior mesenteric artery.

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Participation of social health inspectors in organizing and performing routine sanitary inspection. Evaluation of left ventricular function and coronary sinus blood flow during exercise after aortocoronary bypass surgery--influence of previous myocardial infarction. Male or female mice received two different doses of canthaxanthin (7 or 14 micrograms/g body wt/day) starting 15 days before tumor inoculation (7 x 10(7) cells i.p.). Analysis of plant proteins using immunological techniques based on the antigen-antibody precipitation. Core-lipid A on the K40 polysaccharide of Escherichia coli O8:K40:H9, a representative of group I capsular polysaccharides. We have sequenced the PBP3 gene, dacA, and upstream regions from the wild-type isogenic strain and the laboratory mutant.

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Employing host cells with differing metabolic capacity, such as Reuber vs. Pulmonary-heart insufficiency in patients with progressing muscular dystrophy. Importantly, we extend these in vitro studies to demonstrate that the CArG box and SRE are functionally interchangeable, both in Xenopus embryos and mouse fibroblasts. Leukemic cell colony formation in soft agar by bone marrow cells and peripheral blood cells from untreated acute leukemia patients. A novel mutation affecting the synthesis of major outer membrane proteins OmpF and OmpC in Escherichia coli K-12 is described. Critical thinking, health policy, and the Hmong culture group, Part I. Aggregating brain cells prepared from embryonic rats bind radioactive opiates in a stereospecific manner. A six-week enriched sensorimotor, communication, and recreational summer day camp for twenty multihandicapped preschool children is described. A randomized phase II study of a new tick-borne encephalitis vaccine using three different doses and two immunization regimens.

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The present paper on the perilimbal zone of the guinea pig conjunctival epithelium describes the ultrastructural organization of the basal cell layer, including basal epithelial cells, melanocytes and small lymphocytes, as well as the intermediate cell layers consisting of polyhedral cells and processes from the melanocytes and the small lymphocytes. Ki67 and 4F2 antigen expression as well as DNA synthesis predict survival at relapse/tumour progression in low-grade B-cell lymphoma. Adverse events were few in both groups and could not be related to medication. salmonicida was shown by hybridization against reference strains and clinical isolates of A. Information characteristics of dual-layer neuronal networks with binary plastic synapses. Studies on immunoglobulin production in human-mouse somatic cell hybrids suggest: 1. The metabolic clearance rate (MCR) for ACTH in adult dogs was previously shown not to vary significantly with varying plasma ACTH concentrations or among dogs.

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The effect of thrombin-like snake venom proteases (Ancrod of Agkistrodon rhodostoma and Batroxobins of Bothrops moojeni and Bothrops marajoensis) on skeletal muscle actin was studied and compared to the thrombic cleavage of this protein. Most traditional methods of immunization involve parenteral vaccines. Of a series of recombinant fragments, the amino-terminal fragments, TF (1-144) and TF (1-247), cofractionated with ribosomes from cell extracts and rebound to isolated ribosomes in vitro. These data indicate that calcium channel blockade reduces noise-induced microvascular permeability. However, objective tests were only moderately reduced when compared with normal values. Comparison between antifibrinolytic and antiprostaglandin treatment in the reduction of increased menstrual blood loss in women with intrauterine contraceptive devices. The importance of determining the blood level of triiodothyronine (T3) in thyroid pathology. Group (2), in which ICP rose above 20 mmHg but was controlled by therapy (group II, 8 cases). EBV induction did not result from fusion of either producer or non-producer cells with mouse cells (L-M (TK-) Cl1D and MCB-L). Effect of limb tourniquet on cerebral perfusion pressure in a head-injured patient.

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Luteinizing hormone added to the incubation medium increased steroidogenesis and cyclic AMP synthesis many fold. Lack of sex dependence of the serum level of immunoreactive erythropoietin in chronic anemia. Hibernating temperature of the bat, Myotis californicus pallidus. Ventricular relaxation and myocardial ischemia: a comparison of different models of tau during coronary angioplasty. Hepatic steatosis is a major risk factor in ischemia-reperfusion (I/R). Diagnosis of Duchenne and Becker muscular dystrophies by polymerase chain reaction. The main result was that a larger fraction of fibroblasts than of mesothelial cells was stimulated to proliferation, regardless of the hour of treatment with Compound 48/80. A microtiter solid phase radioimmunoassy for hepatitis A antigen (HA Ag) and antibody (anti-HA) was developed.

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Studies on the isolation and biological properties of enterotoxic Staphylococci A and B. Calcium deficiency increased cAMP excretion irrespective of Mg status, although nephrocalcinosis appeared only in the Mg-deficient animals. T cell receptor (TCR) transgenic adalat 30 mg prospect mice specific for hen egg lysozyme (HEL) were crossed with mice expressing HEL on the thyroid epithelium, on pancreatic islet beta cells, or systemically. Amino acid sequence of a heat-stable enterotoxin isolated from enterotoxigenic Escherichia coli strain 18D. Comparative analysis of interaction of ligands with muscarinic receptors in isolated heart muscle and myocardium homogenate.

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The second cluster included one sternal and five leg incisions, an infected internal defibrillator incision site, and one tetracycline medication class pneumonia. Effects of different patterns of feed restriction and insulin treatment during the luteal phase on reproductive, metabolic, and endocrine parameters in cyclic gilts. Studies on the recombination of nucleic acids with a tissue polypeptide. Lymphography carried out via lymphatics in the foot was negative in 3 cases where it was carried out. At the first echocardiogram the shortening fraction was decreased.

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Determination of trace elements by an assay using flameless atomic absorption spectrometry. The specificity and sensitivity of immuno-assays can be usefully exploited for early detection of digestive bleeding disorders. In all four recipients of BMT who obtained engraftments, serum levels of total MBP started to increase 12-14 days after BMT and reached the highest levels (4-10 times the basal levels) at days 19-32. A within-subject analysis of stimulus control therapy with severe sleep-onset insomnia. Clinical reference values for serum protein electrophoresis for the llama (Lama glama). The approximate half-lives of basal and dexamethasone-induced AM mRNA were about 4 h, suggesting that dexamethasone-induced up-regulation of AM mRNA was unlikely due to its decreased degradation.

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Phenobarbitone stimulated an increased NADPH-cytochrome c reductase activity and cytochrome P-450 concentration. Case of malignant granulome treated by massive doses of prednisone. The radioenhancement effects of 5-thio-D-glucose and insulin in vivo on a hypoxic P388 murine leukemia. These results indicate that peripheral hyperinsulinemia in subjects with simple obesity or impaired glucose tolerance is a result of both pancreatic hypersecretion and diminished hepatic insulin extraction. The chromatophores of Rhodospirillum rubrum were found to synthesize in the light does the antibiotic bactrim treat strep throat not only ATP and pyrophosphate but also high molecular weight polyphosphates. Sequelae and symptoms in surgically and non-surgically treated patients with benign gastric ulcer. The precursor polyprotein and VP1 coding regions of highly virulent OKYM strain consisted of 3039 nucleotides (1012 deduced amino acids) and 2640 nucleotides (879 deduced amino acids), respectively. This was shown with strains that are blocked at different positions in central metabolism when they receive sugars that cannot be metabolized past enzymatic block(s).

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Maternal fertility, reproductive loss, and defective human embryos. Two temperature-sensitive (ts) mutants of mammalian cell lines (AF8 and cs4D3) that arrest in G1 at the nonpermissive temperature were fused with chick erythrocytes and the induction of DNA synthesis was studied in the resulting heterokaryons. Correctly estimating the overall rotation correlation time tauR was shown to play the key role in model-free data analysis. Frozen hydrated sections around 100 nm thick can be produced under optimal conditions from vitreous ice or glimepiride 0.5 mg from vitrified biological samples. An outbreak of otitis externa was observed to affect one third of 230 swimmers using a new swimming pool within three weeks of its opening. Purification of recovered tellurium dioxide for re-use in iodine radioisotope production. Ovarian progesterone secretion was significantly, reduced 24 hr after ECR treatment on day 6 or 9 of pseudopregnancy and the secretion rate of 20alpha-OH-P remained constant. The evolution of contrast agents for MR imaging of the liver has proceeded along several different paths with the common goal of improving liver-lesion contrast. The epithelial component includes the surface cells, their apical tight junctions, and membrane transporters.

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Morphometrical and cell kinetic studies of normal human colorectal mucosa. Antiviral activity of an extract of Brucella abortus: induction of interferon and immunopotentiation of host resistance. Need for common nomenclature and definitions in 3-D conformal radiotherapy. Bilateral lung collapse in an asthmatic patient during thoracotomy. TILT was performed at powers of 1-2 W and exposures of 75-600 s.

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Development of bacteriophage phi29 in sporulating and non-sporulating cells of bacillus subtilis 168. Kinetic and mechanistic properties of glutamate semialdehyde dehydrogenase. Trends in transfusion medicine in dogs at a veterinary school clinic: 315 cases (1986-1989). Intoxication and embolism due to intravascular injection of an abortifacient paste. This daily max dose of xanax is the first reported case of a splenic hamartoma associated with renal, cutaneous, and hematological abnormalities and only the second reported case of a symptomatic splenic hamartoma treated by partial splenectomy.

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