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Asmetic (Roxithromycin)

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Asmetic is a semi-synthetic macrolide antibiotic. It is a white crystalline powder. Asmetic is very slightly soluble in water, freely soluble in acetone, in alcohol and in methylene chloride. It is slightly soluble in dilute hydrochloric acid.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Biaxsig, Bicofen, Cadithro, Claramid, Crolix, Delos, Dorolid, Floxid, Infectoroxit, Klomicina, Ladlid, Nirox, Odonticina, Pedrox, Redotrin, Remora, Renicin, Ritosin, Rokilide, Rokithrid, Roksimin, Rolicyn, Rolid, Romac, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin


Asmetic is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Asmetic is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Asmetic is available under several brandnames. Asmetic is not available in the United States. Asmetic is available in Australia, Israel and New Zealand. Asmetic has also been tested to possess antimalarial activity.

Asmetic prevents bacteria from growing, by interfering with their protein synthesis. Asmetic binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Asmetic has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


Take Generic Asmetic by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Asmetic tablets whole with a glass of water. Generic Asmetic should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Asmetic works best if you take it on an empty stomach. For treating bacterial infections, Generic Asmetic is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Asmetic suddenly.


Symptomatic treatment should be provided as required. There is no specific antidote.


Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Asmetic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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A human uterine sarcoma cell line, FU-MMT-1, was used in vivo because this tumor is one of the most malignant neoplasms of the human solid tumors and it also has a poor response to any of the chemotherapeutic agents currently used, as well as to radiotherapy. Identification of genomic targets of transcription factor AEBP1 and its role in survival of glioma cells. It binds to phosphatidylinositol trisphosphate (PtdIns(3,4,5)P(3)) through its PH domain, which is essential for the membrane translocation after EGF stimulation. Age-dependent pre- and postsynaptic distribution of AMPA receptors at synapses in CA3 stratum radiatum of hippocampal slice cultures compared with intact brain. Thermodynamic data correlated with the structural determinations, since PDDF binding was dominated by enthalpic effects while U89 had an important entropic component. The acidic surface of the functionalized nanofiber suggests the presence of carboxylic acid and possibly sulfonic acid groups. Here we demonstrate that nobiletin enhance differentiation of 3T3-L1 preadipocytes. To investigate the association between dose to various anatomical structures and dysphagia among patients with head and neck cancer treated by definitive intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy.

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Recently, the advent of microbubble contrast agents, which can opacify the systemic circulation, has improved the ability of echocardiography to evaluate left-ventricular function by improving delineation of the left-ventricular endocardial border. Variations in brain volume and regional morphology associated with chronic pain. RBF kernel based support vector regression to estimate the blood volume and heart rate responses during hemodialysis. At the same time, deeper bacterial communities represented by obligate symbionts are specific. The essential requirement of ferritins/bacterioferritins (proteins involved in iron storage and homeostasis) for the survival of several prokaryotic pathogens makes these proteins very attractive targets for structure determination and inhibitor design. Zinc(II)-coordinated oligotyrosine: a new class of cell penetrating peptide. DNA sequences of a short fragment of the mitochondrial gene ND4 allowed for the rapid and precise differentiation of both species, coinciding with the separation using genitalia for biaxin generic er both males and females.

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To investigate the interrater agreement and the internal construct validity of the Physical Mobility Scale, a tool routinely used to assess mobility of people living in residential aged care. EMS placement should be reserved for situations in which there is no other reasonable surgical alternative. Our analysis reveals that the adequate description of PSAC gating requires only one exponentially decaying open state, but at least three closed channel states. Cell concentrations can be effectively determined in the range of 10(5)-10(7) cells ml(-1) using a microplate reader at the wavelength of 605 nm. SEM examination indicated that fusion sputtering resulted in the creation of retentive zirconia beads on the treated surface, which enhanced micromechanical retention with adhesive resin and prevented interfacial failure. The present zithromax z pak dosage instructions study examined the way retirees perceive retirement and continue to work post-retirement. A generalized trace element mass balance model was developed to evaluate the long-term fate and transport of arsenic and cadmium in cropland soils. Adults undergoing EGD for the indication of diarrhea, anemia, iron deficiency, or weight loss, in which the endoscopic appearance of the upper GI tract was normal. However, it is yet to be established whether the formation of bladder flap is advantageous.

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Clinical guidelines are a major tool in improving the quality of medical care. Ki-67 was positive with basal expression in 16/28 of the tumour samples, 15 of which also expressed p21. The results show a high percentage of patients attending rapid access clinics were aware of the campaign. Several new workflow implementations demonstrate the flexibility and what class of medication is cardizem benefit of this approach for rapid dynamic experimental design on a chromatographic timescale. In line with this hypothesis, the circling behavior of the ci2 and ci3 mutants is intensified by amphetamine.

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Chemical stimulation of the pulmonary irritant receptor and type-J receptor induced a sphincteric tight closure of the velopharynx but only a weak inward movement of the lateral pharyngeal wall at lung inflation. The aim was to determine whether threshold properties of single motor units (SMUs) within SHLP during jaw tasks were comparable to those identified for IHLP. Comparison of HbA1c in Chinese patients with type 1 or type 2 diabetes randomized to twice daily insulin lispro low mix 25 or twice daily human insulin mix 30/70. We were able to find 30 reported cases of distal neuropathy revealing a NHL including, 8 mononeuritis simplex, 9 MM and 13 polyneuropathies. Reports to the Vaccine Adverse Event Reporting System (VAERS), a passive national surveillance system. In the present work, a vehicle emitting a known amount of sulfur hexafluoride (SF6) was driven repeatedly through a 730-m-long traffic tunnel in Vancouver, Canada.

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A 3.5-month-old girl was diagnosed with type I truncus arteriosus and severe pulmonary hypertension. Clinical, radiologic, and lung function findings then resolved without the use of corticosteroids or nonsteroid immune modulators. In our opinion this single toe transfer method gives an acceptable pinch reconstruction for hand amputation patients. Combined before-and-after treatment with Ed significantly ameliorated the KA-induced decrease of glutathione and blocked the KA-induced increase of 4-hydroxy-2-nonenal (HNE). DC is methotrexate a cytotoxic drug offered a superior overall response rate than does EC, along with tolerable toxicity profiles, although the DC drug combination did not show significantly improved survival and TTP. Transcatheter arterial chemoembolization (TACE) with lipiodol to treat hepatocellular carcinoma: survey results from the TACE study group of Japan. The mutation identified in the present investigation extends the body of evidence implicating the gene SMOC-1 in causing WAS.

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A 32-year-old nursing student with hoarseness and dysphagia to solids. Factors influencing phenolic compounds in table olives (Olea europaea). Hybrid stabilization with ALIF L5/S1 and zovirax generic name total disc replacement L4/L5. Low doses of transdermal buprenorphine in opioid-naive patients with cancer pain: a 4-week, nonrandomized, open-label, uncontrolled observational study. Thrombosis with erythropoietic stimulating agents-does iron-deficient erythropoiesis play a role?. ruthenicum fruits from different provinces in terms of chemical composition. The economic side of social remittances: how money and ideas circulate between Paris, Dakar, and New York. Developing and normal adult endocrine cells, hyperplastic endocrine lesions (thyroid, parathyroid, lung, and stomach), and 120 tumors (102 endocrine) were studied. Hypoadiponectinaemia during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia, and hence may be relevant to the pathophysiology relating GDM with type 2 diabetes. These findings are consistent with evidence that only the combined intervention yielded increases in both exercise and stress management activity.

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