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Ativan (Lorazepam)
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Ativan

Ativan is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal. It is used to treat chemotherapy induced nausea and vomiting, as well as for surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. While it can be used for severe agitation, midazolam is usually preferred. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection onset of effects is between one and thirty minutes and effects last for up to a day.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Calan, Aldactone, Urispas, Abhigra, Ventolin, Yasmin, Avodart, Priligy, Flonase

Also known as: Lorazepam

Description

Lorazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat a seizure emergency called status epilepticus. Lorazepam injection is also used as a sedative to help you relax before having surgery.

Dosage

The Ativan dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Ativan to treat
  • your age
  • the form of Ativan you take
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Drug forms and strengths

  • Tablet: 0.5 mg, 1 mg, 2 mg
  • Solution for injection (IV): 2 mg per mL, 4 mg per mL

General dosage information

The usual oral dosage for Ativan tablets is 2 to 6 mg daily. This dosage amount is usually divided and taken two or three times daily.

Dosage for anxiety

Typical dosage: 1 to 3 mg taken two or three times daily.

Dosage for insomnia due to anxiety or stress

Typical dosage: 2 to 4 mg at bedtime.

Dosage for IV Ativan

  • Intravenous (IV) Ativan will be given by your doctor or nurse. Your doctor will determine the best dosage for your condition.

Special dosage considerations

Older adults and people with certain physical conditions may need to start with a lower dosage. This might be 1 to 2 mg, taken two or three times daily for anxiety or once at bedtime for insomnia.

What if I miss a dose?

If you miss a dose, take it as soon as you can. However, if it’s just a few hours until your next dose, skip the missed dose and take the next one on schedule.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of lorazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.

Overdose symptoms may include extreme drowsiness, confusion, slurred speech, feeling restless, muscle weakness, loss of balance or coordination, feeling light-headed, slow heartbeats, weak or shallow breathing, or coma.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Ativan is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Ativan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The additive central-nervous-system effects of other drugs, such as phenothiazines, narcotic analgesics, barbiturates, antidepressants, scopolamine, and monoamine-oxidase inhibitors, should be borne in mind when these other drugs are used concomitantly with or during the period of recovery from Ativan Injection.

Extreme caution must be used when administering Ativan Injection to elderly patients, very ill patients, or to patients with limited pulmonary reserve because of the possibility that hypoventilation and/or hypoxic cardiac arrest may occur. Resuscitative equipment for ventilatory support should be readily available.

When Ativan injection is used IV as the premedicant prior to regional or local anesthesia, the possibility of excessive sleepiness or drowsiness may interfere with patient cooperation in determining levels of anesthesia. This is most likely to occur when greater than 0.05 mg/kg is given and when narcotic analgesics are used concomitantly with the recommended dose.

As with all benzodiazepines, paradoxical reactions may occur in rare instances and in an unpredictable fashion. In these instances, further use of the drug in these patients should be considered with caution.

There have been reports of possible propylene glycol toxicity (e.g., lactic acidosis, hyperosmolality, hypotension) and possible polyethylene glycol toxicity (e.g., acute tubular necrosis) during administration of Ativan Injection at higher than recommended doses. Symptoms may be more likely to develop in patients with renal impairment.

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Severe bone marrow necrosis in this setting may be reversible, and continued vigorous supportive care for these patients should be strongly considered. Alteration of electrical activity in molluscan neurones by cyclic nucleotides and peptide factors. Distribution of murine type B and type C viral nucleic acid sequences in template active and template inactive chromatin. A cDNA fragment specific for the rhesus macaque gibbon ape leukemia virus (GaLV) receptor (Glvr-1) was isolated by polymerase chain reaction (PCR) amplification and oligonucleotide primers specific for human Glvr-1 and a cDNA library derived from rhesus macaque brain. In this case, hypopotassemia could not be explained by potassium loss through the kidneys, which suggests potassium excretion in the gastrointestinal tract as the mechanism of hypopotassemia.

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Measurement of serum folate: experience with 75Se-selenofolate radioassay. Beneficial effects of nitric oxide synthase inhibition on the recovery of neurological function after spinal cord injury in rats. In addition, immunoelectron microscopic analysis distinctly localized PfHsp60 in the mitochondrion of P. Oncologic treatment of oto-neuro-ophthalmological metastases and their complications. The purpose of this study was to explore the clinical conditions brought to indigenous healers by people in the rural areas in search of health care. Platelet aggregation was more prominent in unstirred samples incubated with the prostaglandin endoperoxides than in samples similarly incubated with 25 muM ADP.

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Process of care was defined as the quantity and type of data collected and the number of problems identified per patient, which were measured before and after introduction of the POR into the pediatric wards of a regional university hospital, using a standardized audit technique. The six specialties are hematology, obstetrics and gynecology, ophthalmology, otorhinolaryngology, dermatology and sexually transmitted diseases, and lastly psychiatry. Emerging evidence indicates that etiology plays an essential role in the results of mitral valve repair. These predisposing factors cause apposition of particular bony prominences between adjacent toes. Histologic study of cholesteatoma in surgically treated otorrhea. Infectivity titrations and particle counts of adenovirus type 5. However, the ability of ER to interact with a DNA sequence containing the vitellogenin promoter oestrogen response element, as assessed by gel retardation assay, was impaired in the clone showing the greatest degree of oestrogen and antioestrogen resistance.

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Precursors of macrophages were found to be enriched in nylon wool-nonadherent cells which are often used as purified T cells. In the luteal phase, the staining intensity for AR was strongest in the early luteal phase just after ovulation and declined gradually thereafter. The role of potassium in the metabolic control of coronary vascular resistance of the dog. Both experimental and clinical studies confirmed the presence of cancer cells in the blood either aspirated or reinfused. Drug use history and criminal behavior among 133 incarcerated men. A new-type titanium intervertebral spacer and its insertion device used in posterior lumbar interbody fusion. We conclude that intravenous injection of Tl-201 during PTCA is useful to assess the alteration of myocardial perfusion due to transient coronary occlusion without increasing the risk of angioplastic procedure. Quantitative biochemical data on whole rat bones (calvarium, femur, humerus) confirmed measurements based on histology which showed that at birth rat calvaria are mostly uncalcified as compared to other species whose bones are mostly ossified at birth. Such an effect of ACh besides the data known from the literature confirms an assumption on cholinergic synaptic transmission within the retina. Is 2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-propane a metabolite of the hypolipemic ciprofibrate?.

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Relationship of acute rheumatic fever to acute glomerulonephritis in Trinidad. Going more deeply into the research with rhythmometric investigations reveals that the temporal organization of psychophysiological functions involving several oscillatory systems may compose possible circadian paradigms of brain integration and pathological chronorisk for clinical neuroscience (seizure susceptibility for epilepsy and related states, brain circulatory disturbances, stress-related events, emotional or affective manifestations, and psychosomatic disorders). Previous studies comparing the activity of these mutants in different hematopoietic cell lines imply that the transmembrane and extracellular mutations act by different mechanisms and suggest amoxil capsules 500mg price the requirement for cell type-specific molecules in signalling. Competitive growth experiments with related pairs of tartrate-fermenting and tartrate-non-fermenting strains of Salmonella typhimurium: relevance to biotyping studies. The results suggest that (1) DHC reduced both contents of TXA2 and PGI2 in vitro.

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To study the interactions of the renin-angiotensin system, sodium balance, and the sympathetic nervous system in the development of coarctation hypertension, an aortic gradient was created with a pneumatic cuff in 11 chronically instrumented conscious dogs. With current equipment, tonometry cannot be recommended for the management of pediatric patients after cardiac surgery. The catalytic subunit of protein phosphatase-1 did not bind to poly(U)-Sepharose, but it bound very tightly after complexation with NIPP-1. In the marine hydroid Hydractinia echinata, metamorphosis transforms the spindle-shaped larva into a primary polyp. Relationship between intra- and postoperative oxygen transport and prolonged intensive care after cardiac surgery: a prospective study.

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Experiences with the radioiodine test in certain internal diseases. The objective observations made by one or more histopathologists experienced in reporting melanocytic lesions, pill identifier generic xanax bars white 555 and the clinical details, mainly from the Sydney Melanoma Unit files, were entered on a detailed protocol. Problems of nutrition of infants and pre-school children in Ghana. Surveillance study of 13 Growth Stents implanted in 12 patients aged 1-15 months (median 5 months). The lymphoma cells from a patient with leukemia lymphoblastic sarcoma (Kiel classification) were observed by scanning and transmission electron microscopy. Uptakes in the reticuloendothelial tissues were 15 per cent and 19 per cent respectively. Relation of the clearing factor of blood plasma after heparin to cholesterolemia.

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As many as 11 patients suffering from hereditary hemochromatosis were examined on the bones and joints with the aid of X-rays. We also observed a distinct periodicity in the sizes of the intramembrane particles found in the stacked regions--7.5, 10.0, 12.5, and 15.0 nm--with the larger-size peaks becoming more pronounced as light intensity decreased. Using a streptavidin surface and a biotin-labelled capture probe, the labelled nucleic acid is bound through the capture probe to the surface, and the amplified nucleic acid is detected using antibody to digoxigenin. In this paper we present an uncommon tumor found in the nasal cavity, the result of a metastasis from primary tumor of testis (embryonal carcinoma) in a young patient of 24 years of age. Listeria monocytogenes was isolated only once from a bovine fetus during this same time period. Whereas administration of KJ resulted in a reduction of the CL intensity in non-immunized mice, in immunized mice it caused a rise in CL intensity. Small vessel size was associated with poor perfusion, despite lower rates of distal embolization. Transient ischemic attacks due to increased platelet aggregation and adhesiveness. The amide bond between the drug and the final amino acid (lysine) appeared to be stable in the incubation milieu. These results demonstrate that a combination of transgenesis and artificial parthenogenesis will make the rapid utilization of genetically pure homozygous transgenic system in vertebrate transgenesis possible.

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Twenty-four hour pattern of luteinizing hormone secretion in normal men with sleep stage recording. The binding of antibodies increased in the sera of patients with the premature menopause syndrome, compared with the control sera. The repA2 gene of the plasmid R100.1 encodes a repressor of plasmid replication. The cis-DDP-resistant cells, however, were found to be partly cross-resistant to cytotoxic treatments with zilascorb (2H). Similarly, outbred stocks of laboratory animals that have a long history in the laboratory, or narrow base, or are maintained in small numbers, will lack variation and become like inbred lines. Effects of p-chloromercuribenzene sulfonate upon ultrastructure of canine gastric surface cells. The doses were increased depending on the response during the six week treatment periods. Replacement of acetoxymethyl by (1-methyl-1H-tetrazol-5-yl)thiomethyl at the 3 position resulted in overall cost of aldactone 50mg improvement in activity both in vitro and in vivo. We examined the effect of selection for age at reproduction on female mating frequency and fertility in female Drosophila melanogaster. Further in the realm of scientific research is the development of immunological approaches and LH-RH/androgen combinations.

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DXB (1 mg/kg BW0.75) and C (16 mg/kg BW0.75) were injected together intraperitoneally (i.p.). Future sonographic developments include the promise of contrast agents. Power of the sib-pair and lod-score methods for linkage analysis of quantitative traits. The laser dose of 5-10 mVt/cm2 for 5-10 min prevents the toxic hepatitis while therapeutical use of 7 to 10 such schedules reduces the intensity of the protein and fat degeneration, parenchymal necrosis and inflammatory infiltration. Coarse precipitates at the cell membrane may consist mainly of cations other than calcium ions. The effects of these measures on the incidence of ventricular arrhythmias during the 30 minutes immediately after coronary artery occlusion were then compared. Furthermore, a close correlation existed between toxicity and n-octanol:water partition coefficients within each class of compounds. This study investigated whether the force-displacement relation remains linear above 100 N. In addition, urinary PGE2 and 6-keto-PGF1 alpha excretions showed no appreciable difference in rats that exhibited progressive renal failure with continuation of the adenine administration period, as shown on the 18th and 24th days. Analysis of classical life-time rodent bioassays conducted over the past 20 years under conditions of Good Laboratory Practice Regulations has led to an improved understanding of possible factors involved in oncogenesis in humans.

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Connections of the nucleus ventralis postero-medialis with the gyrus orbitalis lateralis. Biochemical pattern in experimental exposure of humans to white spirit. Variation in quarter of birth was examined in patients with a clinical diagnosis of AD. Rehabilitation medicine: a changing challenge in a changing society. Division of the breakfast into two portions of standard composition separated by 30 min improved blood glucose levels in diabetic patients considerably, but division in which the first portion was high in protein produced a blood glucose response almost identical to that of normal subjects. Treatment products and approaches for phenylketonuria: improved palatability and flexibility demonstrate safety, efficacy and acceptance in US clinical trials. A randomly selected subsample of human immunodeficiency virus type 1 (HIV-1)-positive homosexual men participating in a controlled clinical trial of a bereavement support group intervention was studied.

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