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Azenil

Azenil is an antibiotic used to treat various types of bacterial infections of the respiratory tract, ear, nose, throat, lungs, skin, and eye in adults and children. It is also effective in typhoid fever and some sexually transmitted diseases like gonorrhea.

Other names for this medication:
Altezym, Amovin, Azicine, Azilide, Azimac, Azimakrol, Azimax, Azithin, Azithrocine, Azitrix, Azomac, Aztrin, Doromax, Ezith, Faxin, Hemomycin, Iramicina, Koptin, Mezatrin, Naxocina, Neozith, Novozithron, Novozitron, Tremac, Zithrox, Zitrim, Zitrocin, Zitrolid

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Also known as: Azithromycin

Description

Azenil is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. In children, it is used to treat middle ear infection, pneumonia, tonsillitis, and strep throat.

Azenil, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.

Bioavailability is 37% following oral administration. Absorption is not affected by food. Azithromycin is extensively distributed in tissues with tissue concentrations reaching up to 50 times greater than plasma concentrations. Drug becomes concentrated within macrophages and polymorphonucleocytes giving it good activity against Chlamydia trachomatis.

Dosage

This section provides information on the proper use of a number of products that contain azithromycin. It may not be specific to Azenil Tri-Pak. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You may take Azenil® oral liquid or tablets with or without food.

Shake well the bottle of Azenil® oral liquid before each use. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Measure the Zmax® extended-release oral suspension with a marked measuring spoon, syringe, or cup. You or your child must take this medicine within 12 hours after it has been mixed with water. It is best to take the Zmax® extended-release oral suspension on an empty stomach or at least 1 hour before or 2 hours after a meal. If your child does not use all of the medicine in the bottle, throw it away after you give the dose.

If you or your child vomits within one hour of taking the Zmax® extended-release oral suspension, call your doctor right away to see if more medicine is needed.

Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

If you are taking aluminum or magnesium-containing antacids, do not take them at the same time that you take Azenil®. These medicines may keep azithromycin from working properly. However, you can take antacids with Zmax®.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (extended-release suspension): For treatment of pneumonia: Adults—2 grams (g) once as a single dose. Children weighing 34 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 2 grams once a day, taken as a single dose. Children 6 months of age and older weighing less than 34 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually 60 milligrams (mg) per kilogram (kg) of body weight once a day, taken as a single dose. For treatment of sinusitis: Adults—2 grams (g) once a day as a single dose. Children—Use and dose must be determined by your doctor. For oral dosage forms (suspension or tablets): For treatment of infections: Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days. Children 6 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 30 milligrams (mg) per kilogram (kg) of body weight once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 5 to 10 mg per kg of body weight once a day for several days. Children younger than 6 months of age—Use and dose must be determined by your doctor. For treatment of pharyngitis or tonsillitis: Adults—500 milligrams (mg) on Day 1 (the first day), taken as a single dose. Then, 250 mg on Day 2 through Day 5. Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight once a day for 5 days. Children younger than 2 years of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Azenil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Azenil overdosage: discomfort feeling in stomach, diarrhea, retching, nausea.

Storage

Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not store the liquid longer than 10 days.

Side effects

The most common side effects associated with Azenil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take antacids that contain aluminum or magnesium within 2 hours of taking Azenil.

Before taking Azenil, tell your doctor if you are using any of the following drugs: nelfinavir (Viracept); digoxin (Lanoxin, Lanoxicaps); ergot medicine such as methysergide (Sansert), ergotamine (Ergostat, Medihaler, Cafergot, Ercaf, Wigraine), dihydroergotamine mesylate (D.H.E., Migranal Nasal Spray); triazolam (Halcion); carbamazepine (Carbatrol, Tegretol); cyclosporine (Neoral, Sandimmune); phenytoin (Dilantin); cholesterol-lowering medicines such as lovastatin (Mevacor), atorvastatin (Lipitor), or cerivastatin (Baycol); a calcium channel blocker such as diltiazem (Cartia XT, Diltiazem, Tiazac), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), verapamil (Calan, Covera-HS); HIV medicines such as indinavir (Crixivan), ritonavir (Norvir), saquinavir (Invirase); alprazolam (Xanax), diazepam (Valium), midazolam (Versed), triazolam (Halcion); theophylline (Theo-Dur, Theolair, Theochron); warfarin (Coumadin); pimozide (Orap); or another antibiotic, especially clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S, Ery-Tab).

If you are using any of these drugs, you may not be able to use Azenil, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can interact with Azenil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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In this article, Dr Goldman reviews the common dermatoses, presents defining characteristics, and suggests treatment options. We searched all databases in Medline, Pubmed, ISI, the Cochrane database, and Embase. Despite the unique dependence of nuclear magnetic resonance (NMR) to motional averaging on different time scales, NMR-based protein structure determination often ignores the presence of dynamics, representing rapidly exchanging conformational equilibria in terms of a single static structure. We then measured the performance of the resulting spell checker by comparing it to manual correction. To begin examining the physiological function of taurine, we generated taurine transporter- (TauT-) knockout mice (TauTKO), which exhibited a deficiency in myocardial and skeletal muscle taurine content compared with their wild-type littermates. It has been suggested, that episodes of temporary bradycardia and hypotension upon balloon inflation could be related to adverse outcome. The behaviour and activity of the genioglossus muscle during sleep is of considerable interest to investigators of obstructive sleep apnea syndrome. In the facultative human pathogen Mycoplasma hominis, which belongs to the cell wall-less Mollicutes, the surface-localised substrate-binding domain OppA of the oligopeptide permease was characterised as the main ecto-ATPase. Starting with one drug and starting with a combination of two drugs are strategies suggested in clinical guidelines as initial treatment of hypertension. In 189 patients, immunohistochemical (IHC) PTHrP tumour tissue expression was evaluated, and OPN and PTHrP in serum were assessed.

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