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Azpax (Clonazepam)
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Azpax

Azpax is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Azpax was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Almac, Anxiset, Azpax, Calmnir, Catier, Clodep, Clonapax, Clonax, Cloneepam, Clonix, Clonopam, Clonotril, Clopam, Closis, Clotas, Clotweet, Cloze, Convaclon, Deptune, Easyfeel, Ection, Eminaz, Epizam, Escitapax, Estalonix, Ezinite, Jbcloz, Klopam, Lonipax, Lozep, Melzap, Norep, Nozim, Nupam, Ozepam, Petril, Repam, Rivotril, Somnotril, Xenotril, Xitzen, Zeficar, Zepam, Zepamax, Zeptril, Zozep

Similar Products:
Differin, Aceon, Risperdal, Suprax, Pamelor, Strattera

Also known as: Clonazepam

Description

Azpax results in a depression of the activities of the central nervous system. This depression is not meant to designate a feeling of depressed mood, although some people may experience depressed mood as a side effect of Azpax use. It instead relates to a reduction in the rate of activity of the cells in the brain. This reduction in the rate of brain activity affects several cognitive functions, most notably the ability to form new memories. Memories are formed in the brain as a result of increased activity of neurons, and a person using a benzodiazepine like Azpax will experience a dampening of these processes that can interfere with the ability to form new memories while one is taking the drug.

There is some evidence that cognitive abilities, such as memory, attention, visual spatial skills, and even intellect, might be affected as a result of long-term benzodiazepine abuse; however, the research in this area is limited due to many of the subjects in the studies having a history of abusing benzodiazepines and other substances, such as alcohol.

Dosage

Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Overdose

Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Azpax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Azpax if you have:

narrow-angle glaucoma; severe liver disease; or a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Restoril, Tranxene, Valium, Versed, Xanax, and others).

To make sure Azpax is safe for you, tell your doctor if you have ever had:

kidney or liver disease; breathing problems; depression, mood problems, or suicidal thoughts or behavior; or porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Some people have thoughts about suicide when taking seizure medication. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

If you use clonazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonazepam on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Do not give this medicine to a child without medical advice. Azpax is not approved to treat panic disorder in anyone younger than 18 years old.

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