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Combivent (Levosalbutamol)
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Combivent

Combivent is used to treat and prevent symptoms (wheezing and shortness of breath) caused by ongoing lung disease (chronic obstructive pulmonary disease-COPD, which includes bronchitis and emphysema). This product contains 2 medications: ipratropium and albuterol (also known as salbutamol).

Other names for this medication:
Levosalbutamol

Similar Products:
Lipitor, Atarax, Levlen, Strattera, Aceon, Alprostadil

Also known as: Levosalbutamol

Description

{name} Respimat are bronchodilators that relax muscles in the airways and increase air flow to the lungs.

{name} Respimat is used to prevent bronchospasm in people with chronic obstructive pulmonary disease (COPD) who are also using other medicines to control their condition.

Dosage

This section provides information on the proper use of a number of products that contain ipratropium and albuterol. It may not be specific to Combivent Respimat. Please read with care.

This medicine usually comes with patient directions or instructions. Read them carefully before using the medicine. If you do not understand the directions or you are not sure how to use the inhaler or nebulizer, ask your doctor to show you how to use it.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine without telling your doctor. To do so may cause your lung condition to become worse.

When you use the inhalation solution, make sure you use a jet nebulizer that is connected to an air compressor with a good air flow. Use a face mask or mouthpiece to inhale the medicine.

Keep the spray away from your eyes. This medicine may cause eye pain or discomfort, irritation, blurred vision, or start seeing halos or odd colors when you look at things. If it does come into contact with your eyes, check with your doctor right away.

To use the Combivent® inhaler:

Insert the metal canister firmly and fully into the clear end of the Combivent® Inhalation Aerosol mouthpiece. This mouthpiece should not be used with other inhaled medicines. Remove the cap and look at the mouthpiece to make sure it is clean. Shake the inhaler for at least 10 seconds and test spray it in the air 3 times before using it for the first time or if the inhaler has not been used for 24 hours. To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece just in front of your mouth with the canister upright. Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once on the top of the canister. Hold your breath for about 10 seconds, then breathe out slowly. If you are supposed to use more than one puff, wait 1 to 2 minutes before inhaling the second puff. Repeat these steps for the second puff, starting with shaking the inhaler. When you have finished all of your doses, rinse your mouth with water. Clean the inhaler mouthpiece every day with hot water. Dry it thoroughly before use.

To use the Combivent® Respimat® spray:

Insert the cartridge into the Combivent® Respimat® inhaler. Before using the inhaler, prime it by spraying the medicine towards the ground (away from your face), until an aerosol cloud is visible. Repeat 3 more times. The inhaler is now ready for use. If the inhaler is not used for more than 3 days, prime the inhaler once to prepare it for use. If it not used for more than 21 days, prime the inhaler 3 times. To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once the release button of the inhaler. Hold your breath for about 10 seconds, then breathe out slowly. After using the inhaler, clean the mouthpiece with a damp cloth or tissue at least once a week. This inhaler has a dose indicator window that shows how much medicine is left. When the pointer enters the red area of the scale, it is time that you need to refill your prescription. Throw away the inhaler 3 months from its first use or when the inhaler is locked (after 60 or 120 puffs).

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For symptoms of chronic obstructive pulmonary disease (COPD): For inhalation aerosol dosage form (used with an inhaler): Adults—2 puffs four times a day and as needed. Do not use more than 12 puffs in any 24-hour period. Children—Use and dose must be determined by your doctor. For inhalation solution dosage form (used with a nebulizer): Adults—Use one 3 milliliter (mL) vial in the nebulizer four times a day. You may use 2 additional treatments per day if needed. Children—Use and dose must be determined by your doctor. For inhalation spray dosage form (used with an inhaler): Adults—One puff four times a day. You may take additional doses per day if needed. Do not use more than 6 puffs in any 24-hour period. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Combivent Respimat can be fatal. Overdose symptoms may include chest pain, fast or pounding heartbeats, tremors, dry mouth, extreme thirst, muscle weakness or limp feeling, severe headache, pounding in your neck or ears, or feeling like you might pass out.

Storage

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Combivent Respimat dosage information

Side effects

The most common side effects associated with Combivent are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Effect of thiouracil on serum and liver cholesterol of the athyreotic rat. Action of alkylating agents on nitrogen fixation by clones of Anabaena doliolum Bharadwaja. The Ki values of 10 microM for pppGpp and 200 microM for ppGpp are far below the concentrations of these nucleotides in nutritionally stressed cells. Deficiencies of tinfoil substitutes in the processing of acrylic resin. The compact multifactorial enhancer complex includes a nuclear factor I (NF-I)/TGGCA binding site, homologies to AP1, and octanucleotide or enhancer core consensus motifs.

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Fluorinated substrate analogs: routes of metabolism and selective toxicity. (b) Production of radial glia continues until at least embryonic day (E) 8, after the peak of neuronal birth is over (approximately E5) and after radial migration of immature neurons has begun (E6-7). Determination of neutralizing antibodies against poliomyelitis before and after Salk vaccination in infants and small children. Significance of a positive test for occult blood in stools of patients taking anti-inflammatory drugs. Its morphological characteristics are identical in all cases comprising hydropic and fatty degeneration of hepatocytes, their focal necroses in different parts of the lobules, predominantly macrophage and leukocyte infiltration of portal and intralobular stroma. The NMSE was most sensitive to degradation, with alterations in the NMSE value depending on image content and degree of degradation. The turnover of xanthoma cholesterol was intermediate between that of the rapidly exchangeable pool and of the slowly exchangeable pool of body cholesterol. Influence of estradiol and progesterone on the sensitivity of rat thoracic aorta to noradrenaline. Biliary lipid composition in monozygotic and dizygotic pairs of twins. Molecular diagnosis of tuberculosis: current clinical validity and future perspectives.

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Invasion by the carcinoma may have compressed and destroyed the thoracic duct, and caused chylothorax. Sensitivity of the serum TPHA reaction and its diagnostic usefulness in late syphilis. A chemical analysis of the seminal and blood plasmas of the cock. Immune response to Escherichia coli O157:H7 in hemolytic uremic syndrome following salmonellosis. To monitor the existence of avian pathogens in laying chicken flocks, specific pathogen-free (SPF) chickens were introduced into two layer farms and reared with laying hens for 12 months. Loss of nails, associated with alopecia cicatrisata and alopecia areata.

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However, further clinical studies are required before final conclusions in this respect can be drawn. The nature of all injuries sustained during the study period is documented, the childhood tibial fractures are described in detail, and possible aetiological factors are discussed. Preliminary results suggest a disturbing trend toward increasing levels of unprotected anal intercourse. Mechanisms of the augmented secretion of vasopressin during haemorrhage in the vagotomized dog. Administration to rats of E2 produced a reduction of the concentration of receptors to E2 in the cytoplasm of the uterus, kidneys and the liver and an increase in their content in the nuclei of the uterus and the liver. Also for these genes, the extent of codon bias differs between both species, being much higher in D. Relining of the maxillary dentures further stabilized the functional patterns. Subsequent to the decrease in EGF receptors, cells reaccumulated EGF receptors, and this re-accumulation was also unaffected by prolactin. The ultrathin sections of the developing otolith of mouse fetuses 15.5 days to 20 days after birth were observed with the aid of the electron microscope. A notable feature of this analysis was the high level of ALDH transcripts found in the undifferentiated cells of the retina.

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Several DNA regions containing genes involved in poly-beta-hydroxybutyrate (PHB) biosynthesis and degradation and also in fatty acid degradation were identified from genomic sequence data and have been characterized in the serine cycle facultative methylotroph Methylobacterium extorquens AM1. The diameter and length of the various segments of the aortic arch were measured. On the one hand, CBs take part in the storage of RNA transcription and processing components to be used later during embryogenesis. It is not recommended in typhoid fever or in infections due to Ps. The patient had used an oral contraceptive for eight years before she became pregnant.

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A case of transient hypertrophic cardiomyopathy in a twin infant of a diabetic mother. Methods of absorption spectroscopy, emission spectral analysis and X-ray diffraction analysis with follow-up to x-ray examination are tested. Langer type of mesomelic dwarfism as the possible homozygous expression of dyschondrosteosis. Thus, it is likely that both outflow monitoring and error signal variables in the autokinetic effect may be affected by gender, and the two sexes may also have different retinal and/or central processing of visual information. Sites for ectopic transplantation of the pituitary include the kidney capsule of mammals, the anterior eye chamber, the so-called hypophysiotropic area of the brain, the third cerebral ventricle, and the tail of the amphibian tadpole. Combining the two methods did not improve reliability appreciably, suggesting that the methods are effectively equivalent when dichotomous task measures are used. In addition it was anaemic and suffered from severe neonatal icterus. A 40-yr-old woman with alveolar soft-part sarcoma and multiple hypervascular cardiac tumors involving both left and right ventricles is reported. Scanning microwave-induced thermoacoustic tomography: signal, resolution, and contrast.

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The effect of oil-emulsion vaccines on the occurrence of nonspecific plate agglutination reactions for Mycoplasma gallisepticum and M. The experimental approach of B1 receptor mRNA transcriptional regulation, protein synthesis, and maturation is illustrated, based on the biochemical (Northern blot) and functional analysis of isolated organs from rabbits injected with bacterial lipopolysaccharide or incubated in vitro with or without interleukin-1. In such patients, nocturnal decreases in arterial O2 saturation are associated with carbon dioxide retention and may contribute to pulmonary hypertension. Artificial pulmonary ventilation, the special form of synchronized brain activity and its functional state at the early stages of the postresuscitation period. Clinical signs were absent or included weight loss, shivering, dyspnea, and/or neurologic disease. Both the DP-bioactive glass paste and tooth enamel have strong absorption bands at the wavelength of 10.6 microm. In patients with exacerbation of the tuberculous process, the reduction in lung ventilation caused by the impaired mechanical properties of the bronchopulmonary system and capillary blood flow, sharp reduction in lung expansion, increase in bronchial resistance and respiratory work were established. Severe fetal limb anomalities were prospectively diagnosed in two patients with polyhydramnios by sonographic measurement of fetal limb lengths. Cultured human keratinocytes expressed cytoplasmic PR protein and PR mRNA transcripts.

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