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Daklinza (Daclatasvir)
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Daklinza

Daklinza is part of the NS5A Inhibitors class and treats Hepatitis C. They work by interfering with the virus's ability to multiply. NS5A inhibitors are used with other medications, often nucleotide polymerase inhibitors like Sovaldi (sofosbuvir), to treat hepatitis C. Daklinza is only available as a brand name drug.

Other names for this medication:
Daclatasvir

Similar Products:
Imitrex, Abhigra, Atarax, Norvasc, Plavix, Celexa, Detrol, Imovane

Also known as: Daclatasvir

Description

{name} (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

{name} is used in combination with other medications to treat chronic hepatitis C in adults.

{name} treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

{name} must be given in combination with other antiviral medications and should not be used alone. It is usually given with sofosbuvir, with or without ribavirin.

{name} is sometimes used in people who also have HIV. Daclatasvir is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

60 mg orally once a day Recommended Regimen and Duration of Therapy: Genotype 1: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Genotype 3: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Comments: -Dose recommendations also apply to HCV/HIV-1-coinfected patients. -Optimal duration of therapy has not been established for HCV genotype 3-infected patients with cirrhosis or for HCV genotype 1-infected patients with Child-Pugh C cirrhosis. -The manufacturer product information for sofosbuvir should be consulted regarding dosing. The manufacturer product information should be consulted regarding ribavirin dosing and dose adjustments (if applicable). Use: With sofosbuvir (with or without ribavirin), for the treatment chronic HCV genotype 1 or 3 infection

Detailed Daklinza dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Daklinza are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent hepatitis C transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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Principles of water-electrolyte balance and acid-base equilibrium. The authors present the case of a 55-year-old man with a massive pulmonary embolism and subsequent hemodynamic decompensation who was successfully treated by open pulmonary embolectomy supported with cardiopulmonary bypass. Effectiveness and safety mandate that the physicians involved receive regular training in the techniques of helicopter evacuation, first aid, and survival. Clinical and laboratory study of tobramycin in the treatment of infections due to gram-negative organisms. Types of neurons in nucleus gracilis and nucleus cuneatus of the European bison. They are essentially based on inadequate knowledge of physiological and pathological influences. Additional phylogenetic studies are required to understand these cases, and our results should also be considered in light of the large number of island-bird extinctions in historic time. The findings among CCSP-/-1 mice of ultrastructural alterations to Clara cell secretory apparatus, with associated changes in airway lining fluid protein composition, demonstrate that the CCSP-/-1 genotype results in more complex changes to airways than CCSP deficiency per se. Associations between family support and substance use outcomes were examined with bivariate comparisons of abstainers and nonabstainers and with regression models using change in substance use and cumulative substance use as dependent measures. Analysis of myocardial action potential in left ventricular hypertrophy of Goldblatt rats.

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The extracellular matrix of unfixed, unstained rat corneal stroma, visualized with high-resolution scanning electron microscopy and atomic force microscopy after minimal preliminary treatment, appears composed of straight, parallel, uniform collagen fibrils regularly spaced by a three-dimensional, irregular network of thin, delicate proteoglycan filaments. On the basis of this and related observations, background PFCs on bromelain-treated mouse RBCs and on sheep RBCs appear to fall under different forms of homeostatic control. Recent progress in studies concerning the role of this receptor in early embryonic development is discussed. Stochastic effects have been defined as those for which the probability increases with dose, without a threshold. Technique and results of combined pancreatic and renal allotransplantation in man. Plasma growth hormone (GH) response to hypothalamic or extrahypothalamic electric stimulation. Transforming growth factor alpha treatment alters intracellular calcium levels in hair cells and protects them from ototoxic damage in vitro. It is generally accepted that, since all antidepressants are equally effective and the elderly are differentially more susceptible to side effects, those antidepressants with the least side effects should be preferentially used. The myocardial cells lost activity of various enzymes in a patchy manner during prolonged autolysis and practically all histochemical enzyme activity disappeared within 20 days. Charts were reviewed and coexistent diagnoses and past treatments were recorded.

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Mask mode intravenous digital subtraction angiography (IV-DSA) image quality is directly dependent on the arterial time-concentration curve peak and width produced by contrast media. Diabetes in pregnancy among Ojibwa-Cree reported here represent the highest rates reported to date in a Canadian population. In the 8- to 12-year-old group it turns out that these extra calories are derived from unfavorable foodstuffs. These results suggested that NSE and S-100 in CSF would be useful markers for damage of the nervous system and that measurement of both NSE and S-100 might positively indicate whether the damage was neuronal, glial or mixed in origin. The jaundice and cholestasis are interpreted to be hepatotoxic effects because of (1) their temporal relationship to the treatment and (2) the presence of hepatocellular damage. Multivariate study: Only the the PSA is an indepent influence factor. Effect of discontinuous exposure to 25,000 feet simulated altitude on growth and reproduction of the albino rat. An occupation-industry matrix analysis of mesothelioma cases in Australia 1980-1985. Association of leisure time physical activity with the risk of coronary heart disease, hypertension and diabetes in middle-aged men and women. The exclusive localization of the enzyme activity in the 105,000 X g supernatant (in a soluble form) was demonstrated by differential centrifugation of a cell homogentae in 0.25 M sucrose.

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Mouse submaxillary gland renin contains a noncovalently attached fatty acid. Dermatitis herpetiformis is an autoimmune skin disorder frequently associated with gastrointestinal diseases. Meningiomas are the second most common tumor to involve the cerebellopontine angle (CPA), but controversy exists as to whether they can arise within the internal auditory canal (IAC) or whether involvement of the IAC occurs secondarily by extension from the CPA. The gamma-interferon assay for diagnosis of bovine tuberculosis in cattle: conditions affecting the production of gamma-interferon in whole blood culture. First time dose of hydroxyurea was reduced and second time drug was discontinued. Hippocampal rhythm generation: gamma-related theta-frequency resonance in CA3 interneurons. This investigation is a prototype for estimating the value of diagnostic staging tests and the effects of consequent alternative methods of treatment for patients with known malignant conditions. To evaluate the prognosis of stage I endometrial adenocarcinoma, which differs by various prognostic factors. DNA synthetic patterns reveal late synthesis in chromosomal segments that are C-band negative and asynchrony in DNA replication between homologs.

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The objective of this study was to examine toxicological effects in male and female rabbits after repeated oral administration of MOM, non-crystalline solid, for 5 weeks at daily dosages of 400, 800, 1,600 and 3,200 mg/kg. We report clinical, histopathologic findings, and complex management strategies used for a 33-year-old woman with xeroderma pigmentosum and recurrent corneal ulcerations that required corneal transplantation, topical cyclosporin, perilimbic conjunctival resection followed by topical mitomycin C, and corneal dye-laser photocoagulation of neovascularization in the left eye. Non-random chromosomal aberrations associated with multiple myeloma. The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. On the ischemic side of the brain, the concentrations of NAA and Cr were lower than on the opposite side, but the concentration of choline (Cho) was almost the same on the two sides. The commensal species identified as donors in these interspecies recombinational events (N. With administration of moriamine S-2 or caseine hydrolysate the higher level of RNA in tissues with thyrotoxicosis, is normalized, especially in the skeletal muscles. The energy mechanism of phasic changes in the spontaneous electrical activity of the neurons during hypoxia. The basal prolactin (PRL) levels were elevated in all the patients, and blunted responses to 500 mug of iv synthetic thyrotropin-releasing hormone (TRH) injection were found in 9 out of the 10 patients. Behavioral effects in the mouse during and following withdrawal from ethanol ingestion and/or nicotine administration.

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Prolongation of H--Y incompatible skin grafts in mice by neonatal spleen cells. It is hoped that this new technique of imaging the injured myocardium will provide specific and confirmatory diagnosis of myocardial contusion associated with closed chest injuries. There are variations including standardized and flaring, with the flaring (or step-back) the most commonly taught and used. A second heat-stable protein inhibitor of phosphorylase phosphatase from rabbit muscle. The findings suggest that experimentally induced changes in the arterial blood pressure by drugs injected intravenously modify the release rates of adrenaline and dopamine in the intermediate NTS so as to counteract the blood pressure change.

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Additionally, frozen sections of the spleen were prepared to evaluate the effect of DSP on the lymphocyte surface markers like thy 1 and B220 by avidin-biotin complex (ABC) technique. Electrophoretic mobility of PMN cells was not altered by these drug indicating that the effect is not due to changes in membrane charge. Proteinchemical and kinetic features of gramicidin S synthetase. Decorin mRNA levels were 1.8-fold higher in SSc fibroblasts than in control fibroblasts. An image analysis technique has been developed to quantitatively describe the fine vascular patterns observed in ligament tissue.

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X-ray assessment of the functional status of the diaphragm in degenerative-dystrophic lesions of the spine. For magnetic resonance imaging (MRI) of esophageal diseases, we have developed a new contrast-enhancement agent, cellulose-ferric ammonium citrate solution. The most plausible mechanism is one based on renal hemodynamics, given the rapid and complete reversibility that was noted and the finding that most patients had risk factors for vascular disease. the lexical representations of these morphemic units were examined using masked priming. The complex interplay among the various mediator systems, inflammatory cells, and toxic products is recognized as a complicated array of pathways necessary for clearance of a given bacterial infection.

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A single-specimen fecal chymotrypsin test in the diagnosis of pancreatic insufficiency: correlation with secretin-cholecystokinin and NBT-PABA tests. The role of Xlim-1 CT239-403 in the Spemann organizer was analyzed by assaying the axis-forming ability of a series of CCR-mutated constructs in Xenopus embryos. This paper describes the more common and important fetal anomalies which can be demonstrated by ultrasound and indicates the importance of meticulous attention to technique and the significance of the acquistion of skill in real-time sonography by the physician-sonologist. Ten patients died while waiting, and 22 recipients underwent re-CTx. Given the structure of a molecule, it is possible to estimate the positions at which complementary hydrogen-bonding atoms could be found. Pyrazinamide-isoniazid combination in treatment of bone tuberculosis. A case study is reported regarding a 32-year-old man with classic clinical and electrophysiologic features of hereditary motor and sensory neuropathy, type I (HMSN I), a slowly progressive autosomal dominant condition marked by slow motor and sensory velocities and generalized segmental demyelination.

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Clinical picture and treatment of poisoning with organophosphorus chemical poisons (carbophos) in children. Molecular forms of N-acetyl- -D-glucosaminidase from boar epididymis. The hormonal effects of danazol and of a long-acting gonadotropin-releasing hormone analogue (GnRH-a) were studied in women with endometriosis and those with oophorectomy. This suggests that the measured cyclic AMP-binding activity does not reflect developmental alterations of the cyclic AMP-binding regulatory subunit of cyclic AMP-dependent protein kinase. Tumor tissue from six patients with meningiomas was analyzed for estrogen-receptor protein. The first permanent molars were the most severely affected, whereas the lower incisors were the least severely affected. Lesch-Nyhan syndrome due to a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale).

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Therapeutic aspects in mediastinal involvement in acute pneumopathies. Maximal virus and soluble antigen (SA) titers were obtained 36 to 48 h after inoculation of swine testes cells. Tissues heal themselves and we understand little of the structural mechanics of the process. Inducible nitric oxide synthase (iNOS) is expressed similarly in multiple aberrant crypt foci and colorectal tumors from the same patients. An improved animal how much does temovate cost model of intraperitoneal abscess formation was developed in order to study the role of Bacteroides fragilis and Escherichia coli. The methods currently available for diagnosis of Cyclospora are described and compared, including concentration procedures, examination of wet preparations, various staining techniques, and the use of molecular-based assays. Tomato seed and root exudate sugars: composition, utilization by Pseudomonas biocontrol strains and role in rhizosphere colonization.

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Juvenile colonic polyposis with villous adenoma and retroperitoneal fibrosis: Report of a case. The direct observation was possible due to high frequency rates of the seizures. A word of caution concerning photodynamic inactivation therapy for Herpesvirus hominis infections. Histophysiologic approaches underlying methods of correcting reproductive function in patients with the sclerocystic ovary syndrome. To study the relationship between head circumference (HC) at birth (HO) and at 1 y of age (HI) and later outcome variables in children exposed to amphetamine during fetal life through maternal drug abuse. Expression of matrix metalloproteinases in patients with acute myocardial infarction. Such a pattern of labeling was particularly evident in follicles showing the signs of atresia. Viewed as a whole, experimental schistosome egg granuloma might be considered as a mixed, chiefly cell but also humoral antibody mediated immune reaction. Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation.

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Seroprevalence of Helicobacter pylori in patients with colorectal polyps and colorectal carcinoma. The possibility of stimulation of C-reactive protein (CRP) due to inflammation and necrosis caused by cadmium was investigated. It is also possible that the PgR stimulation is maximal already at ER values below those found in ultram 25 mg picture old patients. Surgery for pheochromocytoma: preparation and control of peroperative hemodynamic variations with injectable nicardipine. In the aprotic, dipolar solvents acetonitrile, DMF and propylene carbonate HSO3- is oxidized by iodine.

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A dose of 1 g/kg given at 17h suppresses paradoxical sleep for 7 hours. C-peptide in juvenile diabetics beyond the postinitial remission period. Radioimmunodetection of human colon cancer using 99mTc-MDP-MoAb-A7 in mice. Although up-to-date statistics are not available on the current involvement of the volunteers who were given the initial training, some have remained physically active and continue to be available in their home area. Barley-specific alpha-amylase gene sequences were detected only in addition lines 1 and 6 carrying barley chromosomes 1 and 6, respectively. The institution of a lobectomy patient care pathway appeared to reduce length of stay and costs.

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Hydrogen exchange is an attractive method for observing small populations of partly unfolded states of proteins at equilibrium. RT-PCR technique was used to detect renal inducible nitric oxide synthase (iNOS) expression. These results indicate that glucocorticoids block entry of alveolar epithelial cells into S phase by specifically altering the activation of cyclin E-CDK2 complexes through induction of the CDK inhibitor p21CIP1. It is widely held that the spatial resolution achievable by NMR microscopic imaging is limited in biological systems by diffusion to approximately 1-5 microns. Only the quality of the optical media of the eye limits the resolution of the retinal image.

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Use in digestive cancerology of enteral feeding with continuous slow flow. This article reviews the available data that address racial differences in the cardiac response to exercise and to left ventricular pressure overload and the implications of these findings. The data indicate close adsorption behaviors on the Carbobond porous layer adsorbent and on the carbon molecular sieve Carboxen support used to prepare the packed columns. The values of mechanical parameters predicted by the neural networks, however, had a very high correlation with those observed, namely 0.91 for the load at fracture and 0.93 for the ultimate stress. Therefore, FDG PET imaging may not be used to estimate tumor biologic behavior of breast cancer such as differentiation, histopathologic grading, cell proliferation, or axillary lymph node status.

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These results demonstrated a loose association between the enzyme and the endoplasmic reticulum and that phenobarbital or CCl4 altered the activity of IDP-ase probably by affecting the binding of the enzyme to the structure skeleton of the membrane. A case of recurrent hidradenoma of the external ear with intracranial spread is described. Yet a number of factors suggest that this view might usefully be reconsidered, notably the dissatisfaction with migraine control expressed by many patients and the inconsistencies in treatment patterns observed across clinical practice. In 9 of the 12 cirrhotic livers, contractile fibroblasts (myofibroblasts) were seen containing the classic features of 60-80 A microfilament bundles with electron-dense bodies along with prominent microtubules. Indirect immunofluorescence staining with antibodies GB3 (antilaminin 5) and 19-DEJ-1 (antiuncein) was totally absent. Oncornavirus-like particles in biopsy glucophage type of drug material from a glandular erosion of the human uterine cervix. Glucose tolerance and pancreatic ultrastructure in mice with long-term diabetes induced by EMC virus (M variant) (38518). This review discusses the proposed mechanisms of action of IVIG in autoimmune and inflammatory disorders. Applying transcobalamin II typing after bone marrow transplantation demonstrated that this protein originates partly in the bone marrow.

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Oral immunization with polyvalent bacterial lysate and infection with Streptococcus pneumoniae: influence on interferon-gamma and PMN elastase concentrations in murine bronchoalveolar lavage fluid. 780 women in labour at term, with cephalic fetal presentation, deemed to require electronic fetal heart rate monitoring using a scalp electrode. Loss of inhibitory synapses on the soma and axon initial segment of pyramidal cells in human epileptic peritumoural neocortex: implications for epilepsy. Prolapse of the rectum in young men: treatment with a modified Roscoe Graham operation. Hydrolysis of human serum low density lipoprotein-2 by phospholipase A2. Microscopic examination revealed prominent neo-intimal hyperplasia with subendothelial, cushion-like thickenings but no medial or adventitial alterations. The cardiac response is mediated largely by the vagus nerves, and the vascular responses by sympathetic adrenergic fibres.6. The AT1 antagonist ZD7155 also prevents drug recall zantac diabetic deficits in regeneration following nerve damage, indicating that hypoperfusion is an important limitation for nerve repair. The data also revealed association of Src with SHP-1 in both platelets and lymphocytes and the capacity of Src to phosphorylate SHP-1 and interact with the SHP-1 NH2-terminal SH2 domain in vitro. The Ontario HIV seroprevalence study of childbearing women: results from the first year of testing.

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Antiphospholipid antibodies have been detected in patients with transient neurologic symptoms including migraine aura. Liability in blood group determinations and cross reaction tests?. Gender influenced the performance of monkeys on the task during normal development and after ORB lesions. Study of various application methods for active immunization of fishes with Aeromonas salmonicida, Aeromonas punctata and Vibrio anguillarum. There was no evidence of a diminished quality of life in those who had undergone distal partial gastrectomy. Patients in relapse scored significantly less on the sum score and the four dimensions compared to patients in remission myambutol . This prospective study evaluated 58 patients with cataracts who underwent bimanual microphaco cataract surgery in both eyes. As a result, there are abnormalities of the eyes, skin, oral structures, musculoskeletal system and central nervous system. Psychiatric disorder and cognitive impairment in systemic lupus erythematosus.

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Kinetic analysis of the age related differences in glucose-6-phosphatase activity. Changes in spinal cholecystokinin release after peripheral axotomy. lividans 66 and hybridized with DNA from several different Streptomyces strains. cerevisiae is transferred to Ser/Thr residues via dolichylphosphate mannose. The heat-labile enoyl-CoA hydratase, on the other hand, was detected in the peroxisomal matrix of hepatocyte and proximal tubule epithelial cells. The study included blood pressure screening, follow-up, health education, village-based campaigns, and program evaluation after 6 months of intervention.

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