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Detrol (Tolterodine)

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Detrol is in a class of medications called antimuscarinics. It works by relaxing the bladder muscles preventing bladder contraction. Detrol is used treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination).

Other names for this medication:
Bapter, Concys, Detrusitol, Dezrolala, Flochek, Roliten, Terol, Tolter, Tolterodine, Uftol, Uridin, Urotel

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Also known as: Tolterodine


{name} LA is used in adults to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence (urine leakage).


Usual Adult Dose for Urinary Incontinence:

Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Usual Adult Dose for Urinary Frequency:

Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Detailed Detrol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

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The most common side effects associated with Detrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Detrol if you are allergic to Detrol components. Do not take Detrol while you are pregnant or have nurseling. Avoid alcohol. Take Detrol with care if you are taking bepridil (Vascor),cisapride (Propulsid);chloroquine (Arelan) or halofantrine (Halfan);cyclosporine (Gengraf, Neoral, Sandimmune); narcotic medication such as levomethadyl (Orlaam); or methadone (Dolophine, Methadose);pentamidine (NebuPent, Pentam);vinblastine (Velban);antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), dirithromycin (Dynabac), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), telithromycin (Ketek);medicines to treat psychiatric disorder, such as chlorpromazine (Thorazine), mesoridazine (Serentil) pimozide (Orap), or thioridazine (Mellaril); or heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), procainamide (Procan, Pronestyl), quinidine (Cardioquin, Quinaglute), or sotalol (Betapace), arsenic trioxide (Trisenox); haloperidol (Haldol), droperidol (Inapsine). You should be careful when you are driving or operating machinery. It can be dangerous to use Detrol if you suffer from or have a history of a blockage in your stomach or intestines, untreated or uncontrolled glaucoma, kidney disease, "Long QT syndrome", blockage of the urinary tract (difficulty urinating), liver disease. It can be dangerous to stop Detrol taking suddenly.

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Swainsonine is a useful tool to monitor the intracellular traffic of N-linked glycoproteins as a function of the state of enterocytic differentiation of HT-29 cells. Involucrin is synthesized after keratinocytes have left the basal layer and begun to enlarge, but some time before the onset of envelope cross-linking, which occurs only in the outermost cell layers. Recognizing that the data from these surveys are becoming dated, a multidisciplinary team comprising members from various NIOSH research divisions was established to develop a hazard surveillance strategy for the Institute, including options for a national hazard surveillance survey and database. Evolution of medical pedagogical concepts concerning deaf mutism. Half a year postoperatively a gingival retraction and sequestration of osseous tissue occurred. The Increasing concentration (10-8-10-4 M) of NO donors, Sodium nitroprusside, (SNP) and molsidomine (SIN-1) and a type V phosphodiesterase inhibitor, Zaprinast were added to the organ chambers and a dose response curve was constructed from each experiment. The authors consider that in most cases with traumatic insufficiency of the mitral valve after closed commissurotomy it is possible to perform valve-preserving operations, craniocerebral hypothermia being a reliable method of their maintenance.

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Stable isotope studies have considerable potential to help understand the biochemistry and pathophysiology of inborn errors of metabolism but this has not yet been fully realised. Compared to mean value setting, facebow registration of condylar angle and relations yields no profitable improvement of occlusal accuracy. Root dentin morphology after different modes of citric acid and tetracycline hydrochloride conditioning. Genetic technology of substances important from the therapeutic and diagnostic aspects. Chemical degradation of one particular epitope recognized by monoclonal antibody PP1/117, and designated ep117, occurred after treatment with NaOH, periodate or Proteinase K, suggesting that an O-linked glycoprotein may be involved. Five and 15 mM HCO-3 increased, but 25 mM HCO-3 decreased, deposit of fluoride in enamel. The efficacy of TPA in elevating ODC activity at postnatal ages 1-220 days-old was independent of both soluble-and particulate-associated TPA receptor concentration. We report the case of a 67-year-old woman in whom onset and regression of acute hepatitis were closely related to the time of administration and withdrawal of the smooth muscle relaxant alverine.

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A severe state of even a single symptom may suffice to cause impairment of QOL, although a poor QOL need not necessarily imply that a patient suffers from all the symptoms. Later on arthralgia of the left shoulder and diffuse swelling of both hands and feet appeared. The diabetic hearing impairment was characterized by high frequency sensorineural hearing loss. Data were gathered from 259 students, fieldwork supervisors, and faculty who rated the form on a number of variables. The incidence of fluorescent Y corpuscles in solid tumors (preliminary report). Relative hypermetabolism of the lenticular nuclei (1) occurred irrespective of whether the spasms were cryptogenic or symptomatic, (2) was associated with focal cortical hypometabolism in 22 and focal cortical hypermetabolism in 5 of the 44 infants, and (3) was not characterized by any specific electroencephalographic abnormality during PET. Methylmethacrylate is widely used by orthopaedic and neurosurgeons for bone reconstruction. Normal daily fluctuations in plasma 45Ca, lost after thyroparathyroidectomy, were restored by feeding rats a high-calcium diet.

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It is known that Dalmatia and then Montenegro are the most infected areas in Yugoslavia. A gas jointer developed dermatitis from epoxy resin of Bisphenol A type. Fibrinogen association with platelets from rats with spontaneous or streptozotocin-induced diabetes was significantly greater 10 s or 1 min after addition of ADP (10 microM) than with platelets from their corresponding control rats. Since the 1980s, clinical trial evidence has supported aspirin use in the secondary prevention of cardiovascular disease (CVD). 17 other published cases of hypoplasia of the right ventricle with atrial septal defect are reviewed. The enzyme requires reduced pyridine nucleotide and dialysis prior to assay for optimal activity. Use of X-ray method for examination of thoracic spine in expert practical work makes it possible to detect lesions and mechanism of their formation. At these levels even penicillin G eliminates many Gram-negative urinary pathogens. They evidence the benefits of the wear of soft hydrogel lenses but the limits of their uses too. The clinical value of the pollico-mental reflex in neuropathology.

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We report on 12 children with neuronal ceroid lipofuscinosis (NCL) diagnosed between 1974-1995 in the West of Scotland. Thus ingestion of ethanol should reduce the risk of liver damage following acetaminophen overdosage. Because LDL increases the supply of arachidonic acid for prostaglandin synthesis, we postulate that greater amounts of PGH2/TxA2 are synthesized via calcium activation of phospholipase A2 when acetylcholine is administered to CSD animals. Migration of plastic additives from soft polyvinyl chloride bags into normal saline and glucose infusions. Hemodynamic parameters were compared in 28 patients with ischemic heart disease subject to cardiopulmonary bypass surgery with non-pulsatile (group 1) and pulsatile flow (group 2). Syphilitic uveitis in human immunodeficiency virus-infected and noninfected patients. In the liver diffusely distributed nodules of regenerative hyperplasia were noted. I reviewed factors contributing to diagnostic delay in 12 children who had symptoms of meningitis for more than three days before diagnosis. Activity profile of placental superoxide-superoxide dismutase system in pregnant mice and its possible relation with placental steroidogenesis.

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The epidermal changes associated with psoriasis may be due to the infiltration of inflammatory T lymphocytes and the release of cytokines in response to antigenic stimulation. Studies to date indicate that adenovirus type 11 is the etiologic agent in some but not all pediatric cases of acute hemorrhagic cystitis. Ten minutes before sacrifice they were injected with a single intravenous dose of ferritin. Since electron linear accelerators with energies up to 20 MeV were introduced to radiotherapy it has become easier to irradiate large portals than was previously possible with 60Co unites or betatrons. In the globular stage expression was confined to the basal part of the embryo, suggesting that the promoter is sensitive to regulatory functions active in the primary establishment of polarity in the radially symmetric globular embryo. The peptides were administered alone or together with glucose (40 mg/kg . Pancreatic tumours display different vascularization patterns in the echo-enhanced power-Doppler sonography. Identification and characterization of a novel gene (neurorep 1) expressed in nerve cells and up-regulated after axotomy. Evaluation of a bivalent (CVD 103-HgR/CVD 111) live oral cholera vaccine in adult volunteers from the United States and Peru.

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It is hypothesized that adolescent development involves a redistribution of cerebral functions from lower subcortical structures to higher regions of the prefrontal cortex to provide greater self-control over emotional behavior. For surfaces defined by motion, the lifetimes of the individual points in the patterns were varied, and comparisons were made between the perception of surfaces defined by points and that of more ecologically valid textured surfaces. PRA, aldosterone and norepinephrine levels remain unchanged during dopamine infusion. Future studies employing sequential IVUS examinations are needed in order to determine whether these morphologic differences relate to a delay in initiation of plaques, slower progression of plaques, or other sex-specific modulators of plaque composition. The incidence of nocturnal hypoxemia without upper airway obstruction or daytime hypoxemia is not known but may be small. In addition, both the basal and the fluoride-stimulated adenylate cyclase activities decrease as the embryo age increases, whereas the enzyme sensitivity to epinephrine increases with increasing age of the embryo.

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Analysis of the cause-specific mortality revealed a significantly raised mortality from gastrointestinal diseases, including a significant excessive mortality in the subgroups of benign peptic ulcer and cirrhosis of the liver. Rats were prepared with indwelling IV cannulae, made tolerant to and physically dependent on morphine, then trained to lever press for morphine self-injections on a fixed ratio (FR) schedule of reinforcement. Fifteen isolates of Bacillus species were recovered during a 19-day period after the introduction of an automated radiometric blood culture system. Forty human insulin-producing tumors were investigated with histochemical, immunohistological and ultrastructural methods and extracted for insulin and proinsulin. Following the sociologist Georg Simmel the thesis is presented that quarrel does not destruct social order but constructs. The action of sinusoidal modulated currents with different parameters in experimental chronic infectious salpingitis.

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Single gene for the large subunit of ribulosebisphosphate carboxylase in maize yields two differentially regulated mRNAs. After a brief description of the two most frequently used experimental models of perfused hearts, namely the Langendorff preparation and the working heart preparation, some of the various methods used to induce hypoxia or ischaemia are described, as well as some of the possible techniques allowing to assess metabolic alterations occurring in these pathological situations. Effects of T mitogens on in vivo antibody production to a T-dependent antigen in lines of mice genetically selected for high or low in vitro responsiveness to PHA. Methylchymotrypsin retains unaltered its ability to bind specific substrates, but is essentially inactive. An early and important step in the generation of neural diversity is the specification of individual neuroblasts according to their position. Duodenal somatostatinoma and erythrocytosis in a patient with von Hippel-Lindau disease type 2A.

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At low concentrations and in the absence of exogenous ADP, non ionic as well as ionic detergents provoked a threefold (or fourfold) increase of the respiratory intensities of mitochondria. Care in the MSSU is provided by a rotating group of hospitalists. After all types of transfusion plasma glucocorticoid levels remained relatively constant for one hour and then doubled and then doubled in the second and third hour. Treatment was successful, and the relatively long parasite clearance time and fever clearance time were probably characteristic of P. The surround responses are antagonized by the responsive center and suppressed by the inhibitory surround, but are seen because of their slower dynamics. Endovascular occlusion of the carotid or vertebral artery with temporary proximal flow arrest and microcoils: clinical results. Aging is associated with insulin resistance but the exact molecular mechanism is still unknown. On the basis of this study and previously reported histopathologic studies of tissue compatibility, it appears that ProcoSol is the material of choice as an endodontic sealer/cement. Aneurysmal bone cyst of the axis treated by laminoplasty with autogenous iliac bone.

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Absence of a specific enzyme from liver and brain of Niemann-Pick disease, type C. Based on personal knowledge and involvement the author describes the ideas, the problems, and the people who combined to advance this aspect of optometry. The role of nasal chemical senses in garter snake response to airborne odor cues from prey. Agarose column chromatography has been used to separate plasma lipoproteins into very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL). These cells were non-ciliated cells and comprised a majority of the epithelial cells especially in the ventral/cartilaginous portion of the airway. Chordoma is a rare and slow-growing tumor, with local aggressiveness and preferential localization in the vertebral column. The total amount in malignant bone tumours was 2.4 times higher compared to benign bone tumours. After prostatectomy, hypofibrinogenemia and bleeding were reported earlier. In particular, it is taken into account that the phospholipid membrane is composed of two layers which are in contact but unconnected. These studies indicate that clinically MER may be a suitable alternative to BCG for contact suppression of tumour growth or incorporation into tumour cell:adjuvant vaccines for active immunotherapy.

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Degeneration, destruction, oedema, haemorrhage and thrombosis were observed in tissues from patients who died due to heart, lung, renal and hepatic failure. This difference was most marked with the enzyme from rat liver, especially with 3beta-hydroxyandrostan-17-ones and 3beta-hydroxypregnan-20-ones as substrates. To test if metoclopramide could act through a serotoninergic pathway we have studied the effect of metergoline on the aldosterone response to metoclopramide in 8 normal subjects. A statistically significant difference was also found between lateral condensation of gutta-percha and vertical condensation of warm gutta-percha using Kerr sealer cement. influenzae type B was recovered from seven of the febrile children with facial cellulitis, and one with extremity involvement.

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(Impact of psychiatric walk-in clinic on emergency room of general hospital). Characterization of enterotoxin purified from Clostridium perfringens type C. The patterns of translation may influence the longevity of the joint replacement with respect to stability, loosening of the glenoid component, and wear of the components. A vertex view artifact on 99m Tc-pertechnetate brain scan in a child. Coins are often reported as the most commonly ingested foreign body uroxatral generic name (FB) in children. Mutagenicity of 3 structurally related epoxides, with defined stereochemical configuration, in Saccharomyces cerevisiae and in V79 Chinese hamster cells. Acid-and alkaline phosphatase, 5-nucleotidase and lipase have been localized histochemically in the gizzard, intestine liver and pancreas of Indian parrot, Psittacula krameri.

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Immunopathology of chronic experimental histoplasmic choroiditis in the primate. Adverse drug reactions of DMARDs and DC-ARTs in rheumatoid arthritis. The ilioinguinal nerve entrapment syndrome is an abdominal muscular pain syndrome, characterized by the clinical triad of muscular type iliac fossa pain with a characteristic radiation pattern, an altered sensory perception in the ilioinguinal nerve cutaneous innervation area, and a well-circumscribed trigger point medial and below the anterosuperior iliac spine. Nonprecious alloys for use in fixed prosthodontics: a literature review. This study looked look at the role of the GP as a qualitative research interviewer and aimed to illustrate areas of methodological difficulty using personal can u drink alcohol with plavix observations made during a qualitative study in general practice.

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Studies of lysozyme activity in the saliva of workers in the drug industry. These findings were confirmed by the immunoperoxidase technique in electron-microscopic studies of these antibody classes. Paranemin and synemin are not expressed in neurons, epithelial, and most glial cells, suggesting that these two polypeptides are expressed only in conjunction with desmin or vimentin. Embryoid bodies (EB) derived from teratocarcinoma (TC) OTT6050 were cultured with ascitic liquids (AL) from animals carrying 16-, 22- and 35-day evolved EB. The study comprises observations in 301 Swedish Yorkshire primiparous sows belonging to a research herd. Morphologic and histochemical studies have been performed at light and electron microscopic level on needle-liver biopsy specimens, circulating blood lymphocytes and fibroblast cultures from patients with mannosidosis. The clinical and electromyographic findings in fourteen patients in whom peripheral nerve damage developed after total hip arthroplasty were reviewed (an incidence of 0.7 per cent in 2,012 procedures). Quantitative gated SPECT myocardial perfusion imaging with 201Tl: an assessment of the limitations. Retinoids in the lateral eye of Limulus: evidence for a retinal photoisomerase.

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Empowerment as a source of organizational healing conveys the message that in order to realize wholeness, nurses are dependent upon personal and organizational resources. Increases in chin prominence averaging 2.5 theophylline dog dosage mm appeared within the first year after the operation. Intravenous nitroglycerin in the treatment of cardiac insufficiency. Hyper-IgM syndrome is a rare immunodeficiency disease characterized by markedly decreased serum IgG, IgA, and IgE levels but normal or elevated IgM levels. The 14th International Congress of Internal Medicine, Rome, Oct. Mice primed with M-CSF induced IL-6 in response to a 5-fold lower dose of LPS, and also produced higher levels of IL-1 alpha, IL-10, GM-CSF, TNF-alpha, and IFN-gamma than control mice. Possibilities and limits of prevention, treatment and rehabilitation in the clinical stage of chronic kidney insufficiency. Spermatid degeneration and giant cell formation were observed after spermatocyte degeneration. O3 exposure resulted in no significant effect on maximal work rate, anaerobic threshold, or any pulmonary function parameter. A clinical examination assessed levels of oral and denture hygiene, denture-related stomatitis, gingivitis, calculus and root caries.

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The Splotch mutant mouse is proposed to be an animal model for persistent truncus arteriosus. To describe the characteristics and outcomes of patients treated with domiciliary nocturnal support ventilation (NSV). The signal for glucose repression of the lactose-galactose regulon is amplified through subtle modulation of transcription of the Kluyveromyces lactis Kl-GAL4 activator gene. Certain bibliometric features of the early literatures of developing drugs can be used to predict their ultimate clinical fates. A user agreement and disclaimer page, feedback page, and corporate compliance page constitute the supplementary pages on the site. The hypothesis concerning the posttranslational maturation of precursor molecules into smaller active entities is now firmly established in many tissues (e.g., pituitary gland, pancreas) and for all kinds of organisms (e.g. Mechanism of plasma endothelin-1 level elevation and its relation with pulmonary hypertension in chronic cor pulmonale. However, preliminary data do not show a relationship between obesity and death from coronary heart disease in this population. The Nd:YAG laser irradiation of dental enamel was evaluated in enamel demineralization experiments in a Streptococcus mutans culture media.

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Microangiopathic haemolytic anaemia in cancer patients with bone marrow infiltration. Clinico-psychophysiologic evaluation of the effect of pirroksan on the recovery of work capacity in sailors having had viral hepatitis A. Immunized mice which survived challenge were resistant to reinfection, but all were shown to carry persistent sub-patent parasitaemia. Two weeks after vasectomy, 10 rats had bilateral sutured vasal anastomosis, and 10 rats had bilateral glued vasal anastomosis. A method of precipitation with polyethylene glycol (PEG) was used for concentration of HBs-antigen. Excision of small tumors of the skin of the face with special reference to the wrinkle lines. A significant increase (p less than 0.01) in NK activity was demonstrated following exposures at 15 mW/cm2. Diaminodiphenylsulfone or dapsone is a chemical analogue of sulfapyridine, synthesized in 1908. Kinetics of bidirectional active sodium fluxes in the toad bladder. A T-shaped tunnel was created by elevating the parietal pleura at the posteromedial end of the thoracotomy wound.

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The effect of an acute pharmacologic test with prozerin on cardiac and central hemodynamic indices in patients with myasthenia. Three of them showing similar orientation with respect to the supporting foil were averaged after alignment by newly developed three-dimensional correlation methods. Cellular proliferation was evaluated using a colorimetric test for cytotoxicity and by flow cytometry. Suicidal ideation and behavior in youthful nonpsychiatric populations. Shortening the period of rt-PA infusion results in higher peak plasma levels, thus allowing a higher concentration of the plasminogen activator on the surface and inside the occluding thrombus. The release of opioid peptides, gluten exorphins A, which have been isolated from the pepsin-thermolysin digest of wheat gluten, with gastrointestinal proteases was examined. Total glycosylated hemoglobin (HbA1) was measured at each cycle. A product-inhibition study of bovine liver glutamate dehydrogenase.

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A model for the differentiation of B lymphocytes with implications for the biological diovan hct dosing role of IgD. Methysergide, (-)propranolol and spiperone suppressed both the head weaving and hindlimb abduction induced by tryptamine. Destruction of the SM resulted in the disappearance of CCKI fibers in the NTV. In addition, there was a significant linear relationship between the log of the dose and the blood pressure reduction (p less than 0.05). We performed coil embolization of the residual aneurysm following the angiogram. An argument in favor of electrolyte solution for early resuscitation. Hearing changes under binaural noise (various changes in masking among employees exposed to noise).

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A variety of diagnostic procedures are available for the assessment of GERD which include barium swallow, pH probe, scintigraphy, and endoscopy with esophageal biopsy. Equine mononuclear leukocytes exposed to LAE developed prominent morphological changes, including enlargement, clumping and increased numbers of mitotic figures. Recent integrated experimental and modelling studies have shed light on the molecular sources of this variability. Hepatic sinusoids of goldfish contain fenestrations which are arranged into sieve plates. The presence of anticentromere antibody is common in the limited CREST forms of systemic sclerosis, and it is often the only autoantibody specificity present in the sera of patients with the CREST variant. Treatment consisted of cystectomy with prostatic preservation and nontubulized enterocystoplasty. A layer of interstitial material with muscle fibres separates the syncytium from the parenchyme.

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The effect of hybridoma antibody administration upon neutrophil kinetics during experimental type III group B streptococcal sepsis. In order to investigate the effect on urinary oxalic acid excretion, ten patients with jejunoileostomy for morbid obesity were treated with oral calcium. General indications for splenic scanning and value of the technic in the diagnosis and course of malignant hemopathies. The role of the peritoneal reflection in the prognosis of carcinoma of the rectum and sigmoid colon. Promoter mapping with S1 nuclease revealed two start sites located 10 bp and 40 bp downstream of the NtrA-dependent promoter. Bronchopulmonary segments and variations in pulmonary vascular patterns. The transposon giving rise to the altered expression of lysU was found inserted within lrp. The acute effect of growth hormone on GFR is obliterated in chronic renal failure. Immunohistochemical localization of thyroxine (T4) and triiodothyronine (T3) in the rat thyroid gland under various experimental conditions. This report describes a patient with an acute intentional fluoxetine exposure who developed unique cardiovascular and neurovascular toxicity.

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