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Differin (Adapalene)

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Differin is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Differin belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Differin, Requip, Prograf, Cymbalta, Levlen, Provigil

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Differin dosage information

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The most common side effects associated with Differin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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Follow-up of a cohort of 422 children aged from 6 to 13 and conceived by in vitro fertilization. Depression of macrophage functions and T-cell-mediated immunity to listeria infection in tumor-bearing mice and its prevention by PSK. The effect of hypothermia on the structural-functional properties of erythrocyte membranes in albino rats. The evidence presented supports a physiologic role of parasympathetic stimulation in altering ventricular electrical function. MtPT1 protein levels decrease in roots during development of a symbiosis with arbuscular mycorrhizal (AM) fungi, indicating that this transporter is not involved in symbiotic phosphate transport. The cost-effectiveness of four cisplatin-containing chemotherapy regimens in the treatment of stages III B and IV non-small cell lung cancer: an Italian perspective. These data show that both single-dose and 3-week treatment with 5-thio-D-glucose produced a hyperinsulinemic diabetes in male albino mice. The use of levamisole in adequate doses, applied opportunely enhanced the unspecific humoral defense of the body, having no direct influence on the quality of actively built specific immunity. Moreover, modulation detection was poorer at 4, 64 and 128 Hz than at 8, 16 and 32 Hz in the brain-damaged listener, giving his TMTF a bandpass appearance.

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HRG and PGE2 each induced the formation of well-organized, three-dimensional structures with empty spaces in the center and stimulated the expression of urokinase plasminogen activator (uPA) with differential localization of membrane-bound uPA at the focal adhesion points and leading edges of the motile cells. These data suggest that the ameliorating effects of Neurotropin in allergic disorders and pain syndromes may be related to this ability to inhibit activation of the K-K cascade and consequently the formation of BK. Retrospectively, we determined the incidence of unexpected death among 536 patients with hypoplastic left heart syndrome who were discharged to home after stage I surgical procedure. Activity of some synthetic oestrogens determined by experiments on rats. Role of adenoids in the pathogenesis of otitis media: a bacteriologic and immunohistochemical analysis. During the differentiation process, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) facilitate cell survival and differentiation in HiB5 cells as well as in primary cultures of rat embryonic hippocampal cells. GM1 ganglioside does not effectively reduce cerebral infarction caused by permanent focal ischemia. Strategies to increase the safety of neonates, including understanding the profile of the potential kidnapper, reviewing common methods of abducting infants, developing visiting guidelines, and instituting staff identification policies and other methods, are discussed.

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Immediate and late outcomes of surgical treatment in patients with tumor-simulating pulmonary tuberculosis. Such a study may help to better highlight the testicular morphophysiology. Females pivot around a point more posterior on the longitudinal axis than do males, producing a greater amount of movement of the snout in relation to the pelvis. Demonstration of size variation of RNA segments between different isolates of calf rotavirus. The development of a light curing prosthesis for chest wall replacement.

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Noise exposure and permanent hearing loss of textile workers in Thailand. The method appears to be safe, and it produces better shaped breasts than we obtained by operations using double pedicles. Clinical, functional and neuroradiologic characteristics exemplified by a rare case. atenolol chlorthalidone dosage A spontaneous segregant, pTN2, appearing from pTN1, conferred inducible synthesis of TOL enzymes. Effect of dorsal hippocampal lesion compared to dorsal hippocampal blockade by atropine on reference memory in vision deprived rats. In all subjects, our technique gave unequivocal frequencies of antral contractions at each time point. The contractile response elicited by cholecystokinin was not reduced following pretreatment with atropine.

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13S condensin is able to introduce positive supercoils into a closed circular DNA in the presence of bacterial or eukaryotic topoisomerase I. Information--movement coupling: implications for the organization of research and practice during acquisition of self-paced extrinsic timing skills. Calcium and cAMP as signal transmitters are again subject to the positive and negative modulating receptor-transmitted effect of adrenergic and cholinergic transmitter substances and beta-cytotropic peptide hormones. Ceftazidime, as a single antibiotic, in the treatment of multi-resistant Gram-negative infections in intensive care. In two cases catheterisation showed the haemodynamic picture of mitral obstruction, and in 1 case the typical findings on auscultation of mitral stenosis were present. These variations in class II compartmentalization are accompanied by dramatic alterations in the intracellular transport of the new class II molecules and in antigen presentation. Nine years later she presented with night blindness, severe diarrhea and mild jaundice and was found to have malabsorption with vitamin A and K deficiencies as well as asymptomatic liver cirrhosis.

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Gene list on a plant tumor-inducing plasmid, pti-SAKURA in Agrobacterium tumefaciens MAFF301001. Salivary testosterone levels and the progress of puberty in the normal boy. Intestinal adaptation to a low Ca diet was still observed in EHDP-treated TPTX rats. The fluorescence of the corticotrophs increases on day 18, shows a maximum on day 19 and decreases until term. Mice were killed at intervals up to 18 days after inoculation, and their tissues were examined for the presence of MHV antigen by indirect immunofluorescence. Family rehabilitation of psychiatric patients: a study of course of involuntary admissions to a psychiatric hospital. Defects in early B-cell development: comparing the consequences of abnormalities in pre-BCR signaling in the human and the mouse. Probabilities of continued response indicated some advantage for methotrexate and median response durations at this time were twice as long for methotrexate (32 weeks) as for cis-platinum (16 weeks), theolair drug information with estramustine phosphate intermediate (23 weeks). No correlations were observed among IgE levels, levels of IgE antibodies to ascaris and levels of IgE antibodies to mite. All patients responded successfully to standard antibiotic therapy with gentamicin or ofloxacin.

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