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Glucophage

Glucophage is an anti-diabetic medication. It works by lowering glucose production in the liver, delaying the absorption of sugar from the intestines, and increasing the body's sensitivity to insulin.

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Also known as: Metformin

Description

Glucophage is a famous medication which provides treatment type 2 diabetes. Glucophage acts controlling and decreasing glucose (sugar in blood). Glucophage is oral antihyperglycemic drug from the biguanide class. Glucophage is also known as Metformin, Phage, Riomet, Fortamet, Glumetza, Obimet, Dianben, Diabex, Diaformin. Glucophage is not taken to treat type 1 diabetes. You can normally take insulin while using Glucophage. Generic name of Glucophage is Metformin. Brand names of Glucophage are Glucophage XR, Fortamet, Riomet, Glucophage, Glumetza, Diaformin, Diabex.

Dosage

Usual Adult Dose for Diabetes Type 2:

Immediate-release: Initial dose: 500 mg orally twice a day or 850 mg orally once a day Dose titration: Increase in 500 mg weekly increments or 850 mg every 2 weeks as tolerated Maintenance dose: 2000 mg daily in divided doses Maximum dose: 2550 mg/day Extended-release: Initial dose: 500 to 1000 mg orally once a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2500 mg daily Comments: -Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus. -Immediate-release: Take in divided doses 2 to 3 times a day with meals; titrate slowly to minimize gastrointestinal side effects. In general, significant responses are not observed with doses less than 1500 mg/day. -Extended-release: Take with the evening meal; if glycemic control is not achieved with 2000 mg once a day, may consider 1000 mg of extended-release product twice a day; if glycemic control is still not achieve, may switch to immediate-release product. Use: To improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.

Usual Pediatric Dose for Diabetes Type 2:

10 years or older: Immediate-release: Initial dose: 500 mg orally twice a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2000 mg daily Comments: Take in divided doses 2 to 3 times a day with meals. Titrate slowly to minimize gastrointestinal side effects. Safety and effectiveness of Glucophage extended-release has not been established in pediatric patients less than 18 years of age. Use: To improve glycemic control in children with type 2 diabetes mellitus as an adjunct to diet and exercise.

Detailed Glucophage dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Glucophage are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Glucophage if you are allergic to Glucophage components. Try to be careful with Glucophage while you are pregnant or have nurseling. Glucophage can't be used by patients under 10 years. Glucophage XR (extended-release tablets) can't be used by patients under 17 years. Glucophage is not taken to treat type 1 diabetes. You can normally take insulin while using Glucophage. Do not use Glucophage in case of taking probenecid (Benemid); aspirin and other salicylates; sulfa drugs (Bactrim); beta-blockers; monoamine oxidase inhibitor (MAOI); allergies, colds, asthma medicines; thyroid medicine (Synthroid); seizure medicines (Dilantin); phenothiazines (Compazine); diet pills; isoniazid; steroids; hormones including birth control pills. Try to be careful with Glucophage in case of using such medication as morphine (MS Contin, Kadian, Oramorph); quinidine (Cardioquin, Quinidex, Quinaglute); vancomycin (Vancocin, Lyphocin); cimetidine (Tagamet) or ranitidine (Zantac); nifedipine (Adalat, Procardia); procainamide (Procan, Pronestyl, Procanbid); trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra); amiloride (Midamor) or triamterene (Dyrenium); digoxin (Lanoxin); furosemide (Lasix). Try to avoid Glucophage in case of having lung, kidney, heart or liver disease, high blood pressure, stroke, diabetic ketoacidosis, or kidney failure. Try to avoid Glucophage in case you want to undergo an operation (dental or any other), x-ray or CT scan. Try to avoid unhealthy food. Glucophage can't be used by patients under 10 years. Glucophage XR (extended-release tablets) can't be used by patients under 17 years. If you want to achieve most effective results without any side effects you need to avoid alcohol. It can be dangerous to stop Glucophage taking suddenly.

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Pathogenicity and control of Eimeria mitis infections in broiler chickens. When present in symptomatic patients, peritendonitis was usually associated with acute symptoms. For self antigens like the fifth component of complement (C5) which is not picked up by APC via antigen-specific receptors, presentation has to rely on uptake by nonspecific means. A novel micromethod for the Limulus amebocyte lysate (LAL) assay for endotoxin, based on hydrostatic pressure. This meta-analysis was conducted on six comparative double-blind studies including 771 patients with angina or hypertension in which SR diltiazem 200-300 mg once daily was compared either with placebo or with other agents known not to influence HR (angiotensin-converting enzyme inhibitors, diuretics). The levels of four ECM components, i.e., collagens III, IV, VI, and laminin were markedly decreased in the sclerotic glomeruli as compared with week 8. The effect of the level of dietary calcium and magnesium on the digestibility of fatty acids, simple triglycerides and some natural and hydrogenated fats. Here we show that the presence of a LDL and a HDL can be directly related to an interaction potential with an attractive part and two characteristic short-range repulsive distances.

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Increasing the amount of transmitter released from the presynaptic nerve terminal leads to a prolongation of end-plate currents in the presence of prostigmine. Protoporphyrin showed similar behaviour (pKapp 7.06) with a deviation at lower pH. 4-year IgE research using RAST, RIST and PRIST at the Graz Dermatological Clinic. Serum thyrotropin and thyroxine after thyrotropin releasing hormone in dairy cows fed varying amounts of iodine. Furthermore, SPK-3 and -4 may play different roles in the transduction of various environmental stresses. In nerves, N-CAM-immunoreactive sites were found associated with both the axon and Schwann cell membranes. DNA polymerase alpha, but not DNA polymerase gamma, as isolated from ovaries, was sensitive to aphidicolin. Light microscope morphology of Plasmodium falciparum during a synchronized growth cycle in vitro. The aim was to simulate and characterize the long-term corrosion of a Ga-containing alloy (Galloy, SDI). Since some breast cancers also express the S-100 protein, our aim was to check the diagnostic and prognostic value of the S-100 protein distribution combined with the tumor grade and expression of synaptophysin (Syn), chromogranin A (Chg A), c-erbB-2 oncoprotein and p53 protein in infiltrating and metastatic breast tumors.

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The protein spots analyzed by this method showed quantitative variations of various degrees, particularly in 2 of 247 spots examined. All night spectral analysis of EEG sleep in young adult and middle-aged male subjects. A comparative study of the Bacillus anthracoides culture and its variant has shown that the latter differs drastically from the parent culture in the shape and consistence of colonies, the size of spores and vegetative cells, the rate of spore germination in MPB, and the resistence to steam treatment and chloroactive disinfectants. During the 60 minutes after delivery, there were no statistically significant changes in pH, PCO2, or PO2 of umbilical arterial blood. Understanding the role of immune cells and their regulatory cell surface molecules such as the MHC, CD antigens, and receptors, as well as knowledge of effector systems set into motion such as phagocytes and cytotoxic T-cells, and the effector molecules such as antibodies, complement, and cytokines, have led to better understanding of the complex pathogenesis of periodontal disease. The patient, a 37-year-old man, showed severe hypoxemia upon blood gas analysis, which had been predicted by pulmonary function tests, together with elevated pulmonary arterial pressure revealed by cardiac catheterization. (c) To observe any change in clinical outcome that may result from the use of epidural analgesia in such patients.

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To compare the activity of the CYP3A enzyme expressed by TC7, a cell culture model of the intestinal epithelial cell, to the activity of human intestinal CYP3A4, using terfenadine as a substrate. Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation. Chromatographic and electrophoretic profiles of newly synthesized proteins indicated that all major proteins synthesized in vivo were also synthesized by the isolated cells. Eighteen subjects were assigned to the experimental group, which received the program, while nineteen subjects made up the control group, which received routine medical care. Comparisons of the three sets of data show that contact pressures measured with the pressure pipe system are linearly related (p less than 0.001) to both the contact pressures measured with the pressure-sensitive paper and the calculated average contact pressures. Previous studies have shown that suramin is capable of disrupting autocrine growth involving coexpression of platelet-derived growth factor and its receptors in a fibroblast model for mesenchymal oncogenesis. An in-depth look at each component is needed because fire hazards involve some surprising sources. Platelet-derived growth factor in vivo: levels, activity, and rate of clearance.

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Leigh syndrome associated with the T9176C mutation in the ATPase 6 gene of mitochondrial DNA. The poor metabolizer had a significantly reduced metabolic ratio of hydroxyajmaline/ajmaline, which indicates that ajmaline metabolism probably co-segregates with polymorphic sparteine/debrisoquine/dextromethorphan metabolism. The laser dye rhodamine 123 specifically stains mitochondria in living cells and facilitates the observation of changes in mitochondrial distribution in single cells under a variety norvasc tablets side effects of experimental conditions. Mouse major (gamma) satellite DNA is highly conserved and organized into extremely long tandem arrays: implications for recombination between nonhomologous chromosomes. Standardized respiratory symptom questionnaires were administered. Disrupted neural responses to phonological and orthographic processing in dyslexic children: an fMRI study. Duration of sleep and its relationship to age, personality and psychiatric illness. The number of persons aged 65 or over was 458,156 in 1972 and 707,341 in 1993. Canine intestinal vasoactivity during the development of the gastrointestinal radiation syndrome.

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Although all statins show a hepatoselective disposition, the mechanism for pravastatin is different from that of the others. Critical care nurses can contribute skill and knowledge in the care of patients with traumatic brain injury and in efforts to prevent the accidents and violence that cause traumatic brain injury. Unsuspected gonorrhea and chlamydia in patients of an urban adult emergency department: a critical population for STD control intervention. Although attitudes toward the allocation system differed by race, with African American patients more suspicious of the system, the importance patients placed on antigen matching did not appear to differ by race. There is now considerable literature on the importance of phosphatidylinositol cycle activation in transducing information of various types across the plasma membrane.

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An outstanding Soviet scientist (on the 40th anniversary of the award to N.N. The apparatus measures the integral depth temperature and the integral factor of reflection from the object. Comparisons of dose effectiveness of Fenoterol (Berotec) given in diverse oral administration forms. We analyzed data from regional and national health surveys that were conducted from 1984-1992 within the framework of the German Cardiovascular Prevention Study. Human scalp hair as evidence of individual dosage history of haloperidol: method and retrospective study. The site of entry plays a critical role in determining the likelihood of serious injury associated with penetrating gluteal wounds. This was investigated in vitro on normal and OA human chondrocytes treated or not treated with interleukin-1beta (IL-1beta).

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A model with a spreadsheet algorithm is used to predict the effects of a pressure pulse on the trajectories of component bands on the column ensemble. To reduce the exorbitant operator analysis time and operator-dependent measurement variations of manual slice-image editing, we have devised a semiautomatic method for LV-chamber extraction. Liver membranes display low-affinity binding for TRH with a dissociation constant similar to the low-affinity binding component of brain membranes. Some results obtained with Norwegian hepatitis patient sera are included. Amplification of ssb-1 mutant single-stranded DNA-binding protein in Escherichia coli. The sample was divided by family history of gastric cancer and H. A complete NotI restriction map covering the entire long arm of human chromosome 11. Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium.

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Effect of hyperprolactinemia induced by neuroleptic agent, timiperone, on porphyrin content of mouse harderian gland. Our findings suggest that the cardiovascular collapse was caused by the non-competitive adrenoceptor antagonism of amiodarone resulting in secondary autonomic insufficiency. An investigation of mandibular morphology in subjects moduretic drug class with different vertical facial growth patterns. Changes of the corneal endothelium after ultraviolet-B exposure in previously photokeratectomized eyes. Glossina austeni oogenesis throughout its nine-day pregnancy cycle is described with the focus on previtellogenic stages. The immune defensive mechanism in parasitic infection with eosinophilia.

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