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Imitrex (Sumatriptan)

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Imitrex is an inexpensive drug used to treat migraines. It is more popular than comparable drugs. It is available in generic and brand versions. Generic Imitrex is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Migratan, Sumatriptan, Suminat, Sumitrex

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Also known as: Sumatriptan


{name} Statdose is a headache medicine that narrows blood vessels around the brain. This medicine also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

{name} Statdose is used to treat migraines and cluster headaches in adults. This medicine will only treat a headache. {name} Statdose will not prevent headaches or reduce the number of attacks.

{name} Statdose should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches.


Use sumatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.

Sumatriptan is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

This medicine comes in a vial (bottle), a needle-free injector device, or a prefilled cartridge for an auto-injector syringe. Each type is for one use only.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use sumatriptan if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Prepare your injection only when you are ready to give it. Do not use a vial if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

After an injection: If your headache does not completely go away, call your doctor before using a second injection. If your headache goes away and then comes back, use a second injection if it has been at least 1 hour since your first injection. Do not use more than 2 injections in 24 hours. Call your doctor if your symptoms do not improve.

Store at room temperature away from moisture, heat, and light. Throw away any unused medicine after the expiration date on the label has passed.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Detailed Imitrex dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include tremors, skin redness in your arms or legs, weakness, loss of coordination, breathing problems, blue-colored lips or fingernails, vision problems, or a seizure (convulsions).


Store at room temperature between 2 and 30 degrees C (36 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Imitrex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Imitrex if you are allergic to sumatriptan, or if you have ever had:

heart problems, or a stroke (including "mini-stroke"); coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; a heart disorder called Wolff-Parkinson-White syndrome; uncontrolled high blood pressure; severe liver disease; or a headache that seems different from your usual migraine headaches.

Do not use Imitrex if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, serious infections, or prevention of nausea and vomiting. These medicines may interact with sumatriptan and cause a serious condition called serotonin syndrome.

To make sure Imitrex is safe for you, tell your doctor if you have ever had:

liver or kidney disease; epilepsy or other seizure disorder; high blood pressure, a heart rhythm disorder; or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or being older than 40 and a man).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using Imitrex. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

Imitrex is not approved for use by anyone younger than 18 years old.

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Recent developments in animal psychopharmacology were reviewed with special reference to our 10-year studies in confirming the disinhibitory theory of chlordiazepoxide in frustrative nonreward (rats), spontaneous alternation (rats), discrimination reversal (rats), successive discrimination (rats), go/no-go type descrimination (rats, monkeys), passive and shuttle avoidance (rats) and differential heart rate conditioning (rats). and acid-catalysed deamination to fumarylpyruvate (trans-2,4-dioxohept-5-enedioic acid) as cis-4-amino-6-carboxy-2-oxohexa-3,5-dienoate, thus demonstrating direct cleavage of the monohydroxylated substrate 5AS to a non-aromatic ring-fission product. The results indicate that TPH activity in striatum is involved in the mechanism of catalepsy in mice. In modem medicine, central venous catheters (CVCs) have a pivotal role in the management of critically ill patients. The increase of the S-phase fraction was correlated to the numbers of lymphocytes in the tumor cell suspensions before LSM centrifugation. Effect of maternal carbohydrate intolerance on the development of the autonomic innervation of the fetal rat pancreas. The release of transforming growth factors by cells resistant to ethidium bromide and growing on a serum-free medium. Evaluation of the prevalence of skin prick test positivity to Alternaria and Cladosporium in patients with suspected respiratory allergy.

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Neutrophils predominated in the infiltrations after 3 hrs but after 24 and 48 hrs the main cells were macrophages and lymphocytes. Considerable discrepancies between mRNA levels and cell surface protein expression of MHC class I (Kd, Dd and Ld) molecules were observed almost exclusively in the tumours derived from nude mice. The order of mutagenicity was p-nitrobenzyl chloride much greater than benzyl bromide greater than benzyl chloride approximately equal to p-methylbenzyl chloride. Eye tracking abnormalities in patients with cerebrovascular disease. Administration of lead diminished (or did not significantly alter) the incorporation of 14C-amino acids into newly synthesized ferritin protein.

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Effects of gingival curettage when performed 1 month after root instrumentation. Persistent infection with Chlamydia pneumoniae following acute respiratory illness. The tumor of the lacrimal gland may have compressed choroidal vessels and short posterior ciliary arteries with subsequent sectorial choroidal ischemia. Increased hepatic oxygenation following ethanol administration in the baboon. There was no important removal of mexiletine from plasma during hemodialysis, hemofiltration, peritoneal dialysis, or plasmapheresis. Livers and pancreata were removed, weighed and the concentrations of copper and iron were determined. Recent studies have suggested that eIF-5A may be the cellular target of the human immunodeficiency virus type 1 Rev and human T cell leukemia virus type 1 Rex proteins. This approach provides a unified framework that encompasses eigenfunction methods of focusing and quantitative image reconstruction in arbitrary media. All gallbladders demonstrated histologic changes of chronic inflammation and all developed a significant bacterial flora following sphincteroplasty.

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Radical mastoid cavity reconstruction--the pedicled musculofascial flap. Often neglected yet important: the pericardium and its diseases. In addition to these general principles, special measures may be indicated in cases of specific drug overdose. In addition, the two other groups did not show any improvement of memory performance, and no effects occurred in the digit span and visual retention tasks. Desoxyribonuclease activity of rat mammary gland during pregnancy and lactation. The author discusses this unique instructional tool along with the role of the instructor. Vasoactive amines or other substances derived from platelets may play an important role in initiating the process of mesangial uptake. Results revealed that the speech of speakers who used to stutter was perceptually different from that of speakers who never stuttered.

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Decompressive surgery in the tendinitis and tear stages of rotator cuff disease. Obstetric implications of antiphospholipid antibodies: pregnancy loss and other complications. There was no systematic change in the ABP profile over the three study periods regardless of the treatment. Nature of the linkage of the aldehyde residue of natural plasmalogens. The recent concept of chemical radiculitis implies the involvement, not only of mechanical compression, but also of chemical mediators which contribute to the generation of ectopic firing. Pharmacologic and pharmacokinetic profile of mibefradil, a T- and L-type calcium channel antagonist. The role of plant hormones in higher plant cellular differentiation. Similar sympathetically mediated renal vasoconstriction has been implicated in the pathogenesis of early essential hypertension in man.

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We show here that transient forebrain ischemia selectively elevates levels of neuronal apoptosis inhibitory protein (NAIP) in rat neurons that are resistant to the injurious effects of this treatment. This was due probably to adaptation of the remaining small bowel, although spontaneous resolution of bacterial overgrowth is a possible explanation. It is shown that the area under the profile curve for samples preceded by breath-holding is significantly larger than when breathing is normal prior to sample provision (p less than 0.001). Synchronous hepatic metastases of colorectal adenocarcinoma: what is the course?. The phenotypes shown by the mutant strains may be related to deficiencies in the proper synthesis of cell wall components of the mycelial phase of this fungus. To prevent protrusion of the catheter tip, a flexible guide wire 0.038 inches in diameter was inserted into the catheter and the tip of the guide wire was advanced to the bladder. The major two liver peaks (high Km enzymes) decreased with increasing growth rate while the minor two liver peaks (low Km enzymes) increased in one fast growing Morris hepatoma. Finally, bilateral LH injection of 7-CK effectively suppressed eating produced by fasting. An account from a region comprizing approximately 25 per cent of the general practioners in Denmark.

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A case of primary tracheal rhabdomyosarcoma is presented--the second in the English-language literature. We present a case of 56-year-old male patient with intra-abdominal paragonimiasis who underwent laparoscopic excision of abdominal granuloma caused by parasite infection. Biometric studies in the cytological diagnosis of soft tissue tumors. To determine the effect of treating Helicobacter pylori infection on the recurrence of gastric and duodenal ulcer disease. Results showed that added lactate protected in a concentration-dependent manner. Compared to NAD and NADH the Michaelis constants are always increased, the catalytic constants (V/Et) were found to be decreased except for the dihydroform reacting with alcohol dehydrogenase from liver. A vaginal sample was achieved before the intervention and an endo-uterine sample after the procedure. The abnormalities in the p53/p21WAF1 pathway have a significant role in the pathogenesis and progression of gastrointestinal stromal tumors. In both protein mixtures some curves exhibited marked distortions such as additional maxima and minima when Pharmalyte 3-10 carrier ampholytes were used for isoelectric focusing in agarose gels. Distal parts of the inducing stimulus affect only the amplitude of the induced modulation.

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Nitrocellulose membrane as an antigen or antibody carrier for screening hybridoma cultures. Effect on anastomotic intimal hyperplasia in femoral arterial dacron bypass grafts. Because of depression and other psychological factors, women may be in greater need of supportive services, and this can affect the success of antiretroviral therapy. Neuroblastoma and the differential diagnosis of small-, round-, blue-cell tumors. Hydroxylation of tyrosine by plant peroxidase and mushroom tyrosinase, with and without hydrazine, to retard the oxidation of dopa. Computerised expert system for the morphological diagnosis of the glomerulonephritis.

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Evaluation of the proximal flow field to circular and noncircular orifices of different aspect ratios. In vivo myocardial bioenergetics during acute volume and/or pressure loading in a canine model: a 31P NMR study. Thirty-two percent of patients with upper zone penetration had associated vascular or visceral injury. Newly synthesized serotonin (5-HT) can be released in the nodose ganglion from the nerve cell bodies of vago-aortic serotoninergic neurones. pylori was able to increase IL-8 production significantly by the epithelial cells used. Vascular anatomy of the distal radius: implications for vascularized bone grafts. The results show that in TMO-treated animals the time to the onset of convulsions, the time to the onset of NADH oxidation-reduction cycles, and the survival time were significantly longer than in the control group. As a result the indications for performing a shunt and the choice of the shunt technique can be more accurately determined.

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Cerebrovascular insult causes focal damage of the central nervous system structures consequently causing loss or disturbance of their functions. Serum vulnerability and time-dependent stabilization of neurites induced by nerve growth factor in PC12 pheochromocytoma cells. Effect of high ambient temperature on the kinetics of the pupillary light reflex in healthy volunteers. A computer imaging system was used to analyse the effects of benzamide (BAM), sodium butyrate and is levlen ed a good pill dimethyl sulphoxide (DMSO) on chondrogenesis in culture. This was seen macroscopically and by light and electron microscopy.

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These observations, although not proving, suggest in this population group, that deeper probing depths taken together with the presence of Aa may have placed an individual at greater risk of tooth loss. Interpretation of data from these investigations is limited because of the mix of health status in the populations studied. Ultrastructural characteristics of microcirculation in tumor nodules of leiomyoma of the uterus. Thrombin suppresses matrix metalloproteinase 2 activity and increases tissue inhibitor of metalloproteinase 1 synthesis in cultured human peritoneal mesothelial cells. Preliminary electron observations on the fibrillar structure of experimental silicotic granuloma. Indication, methods and results of intermittent continuous dialysis treatment. Evidence for the role of serotonin in the inhibition of specific motor responses.

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Bifidobacterium adolescentis modulates the specific immune response to another human gut bacterium, Bacteroides thetaiotaomicron, in gnotobiotic rats. Alveolar type II cells: studies on the mode of release of lamellar bodies. Treatment of advanced cancer of prostate with megestrol acetate. Energetic substrates like fatty acids were also potent activators of glycogen synthase, especially in the presence of glucose. Experimental studies on the influence of ouabain on ATP, calcium and magnesium in the failing human heart. The ratio of plasma protein to hemoglobin is about the same as casein. The calculated temperatures and concentrations were compared with data from different ultram 50mg tablets experiments. The amplitudes for insulin and glucagon were ten and five times greater than for glucose.

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Dystocia in nine British breeds of cattle and its relationship to the dimensions of the dam and calf. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. This compound also decreased calcium uptake in both osteoclastic and osteoblastic enriched bone cell populations obtained by sequential collagenase digestion of 1-2 day newborn rat calvariae. time curve and by the slope of the rise of celexa during breastfeeding this curve, over the longest interpulse interval examined, 170 min. Resolution of pharyngocutaneous fistulas appearing after total laryngectomy. VNFH can replace NIFH in both the biosynthesis of FeMo-co and in the maturation of apodinitrogenase 1. However, N-acetyl-serotonin inhibition of sepiapterin reductase, an enzyme whose previously only known function was the reduction of sepiapterin to 7,8-dihydrobiopterin, completely inhibited biosynthesis of tetrahydrobiopterin by bovine adrenal medulla extracts. Relationship between the roles of monoamine oxidase and sympathetic nerves in the vasoconstrictor response of the rabbit ear artery to norepinephrine.

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AChE activity is seen in the cisternae of the RER, in subsurface cisternae and in the dendritic membranes. The levels of 11-deoxy-17-ketosteroids and dehydroisoandrosterone in urine did not increase. As nursing research becomes more common, so does the issue of whether or not patients should be involved and, if so, to what extent. We show how to design a series of PCRs to attain optimal precision of the estimate. It spreads to the soft tissues beneath the temporal bone and, if not properly treated leads to facial nerve palsy, mastoiditis, sepsis, osteomyelitis of the base of the skull, sigmoid sinus thrombosis, multiple cranial nerve palsies and death.

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Nineteen published cases of cerebral vein thrombosis and a deficiency of either anti-thrombin III, protein C, or protein S were reviewed. The results of serological tests for such patients may not be positive and histopathology remains the only reliable method for confirming the diagnosis of cysticercosis. Administration of opiate agonists and antagonists has been shown to increase and decrease alcohol consumption, respectively. The indications and contraindications for surgical management of expiratory stenosis were determined. IL-1 stimulates collagen synthesis and elevates serum procollagen type 3 peptide (P-III-P). Based on the results described and data in the literature, it is proposed that the same component of VSV B and DI particles is responsible for most, if not all, of the inhibitory activities of VSV, except homologous interference.

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3 Cases of Waterhouse-Friderichsen syndrome treated with noradrenalin with 2 successes. We report a 55 years-old man with disseminated nocardiosis and a 32 years-old man with splenectomy diagnosed of pulmonary nocardiosis. Hypernephromas with parasitic blood supply derived from the superior and inferior mesenteric arteries. Recently, several infrared lasers have been introduced in the dental clinic to remove carious dental hard tissues in anticipation of replacing the high-speed dental drill. An association between low left atrial appendage (LAA) Doppler velocities and thromboembolic risk in NVAF has been reported. Serum phenylalanine levels were slightly increased, while those of tryptophan and tyrosine were occasionally reduced. Moreover there were differences whether the cells were involved in a mucous, a parakeratinized or an orthokeratinized differentiation. Staphylococcus aureus osmoregulation: roles for choline, glycine betaine, proline, and taurine. The correlation between the degree of cord compression shown with MR imaging and the clinical symptoms, especially long tract symptoms, was poor.

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variipennis after oral infection and was transmitted through a membrane by this species of midge 7-10 days after infection. Prolonged viremia and immune response to human herpesvirus 7 in an infant with liver dysfunction. In this article, firstly we want to report our clinical experiments about mainly congenital and development anomalies, vascular disorders, dysmyelinating or demyelinating disorders, and neurodegenerative disorders. Studies examining the molecular defects that cause delayed dark adaptation suggest that the desensitizing substance is recognized by rhodopsin kinase and/or arrestin and, therefore, is probably a complex comprising all-trans-retinal and opsin. Effects of decreasing sedentary behaviors on activity choice in obese children. The purposes of this study were to determine whether ambulatory children with spastic cerebral palsy (CP) had abnormal isokinetic eccentric peak torque values at the knee and ankle, and to gain further insights on the influence of spasticity on voluntary force production in this population. Investigations were conducted in two series of tests on 40 rabbits. A retrospective MR investigation, involving T1-weighted midsagittal images from 169 cases, was undertaken to examine age influences on the anterior wedge (anteroposterior height ratio or Ha/Hp), biconcavity (midposterior height ratio or Hm/Hp), and compression indices (posterior height/anteroposterior diameter or Hp/D) of the thoracic vertebral bodies. Rare earth elements--a new generation of growth promoters for pigs?. Adhesion molecules are known to be important in the regulation of endothelial cell and platelet functions.

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Clinical expressions of algodystrophy are summarized, and principles of treatment are discussed. It has not been possible to prove a direct correlation between xanthurenic aciduria and urinary bladder cancer. The maximum altitude on this trail or old road reached 4800 m (15750 ft), about the same elevation as the summit of Mt. The antibody levels of diseased serum samples were significantly higher than those of healthy serum samples. Stepwise multimodal approach in the treatment of Kasabach-Merritt syndrome. Genetic substructuring as a result of barriers to gene flow in urban Rana temporaria (common frog) populations: implications for biodiversity conservation. How to differentiate acute isopropanol poisoning from ethanol intoxication?. A correlation was noted between the in vivo half-life of antipyrine and the in vitro microsomal data. IL-6 was detected with significantly higher levels in the infertile group compared to the fertile group.

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Adding guanidine.HCl to the acid buffer reagent is a simple way to eliminate this interference. It was shown that 201Tl studies were superior to 67Ga studies for evaluation of the primary lesion and lymph node metastases. It is concluded that in the rabbit prostate there are two smooth muscles bundles which are respectively contracted with associated depolarization by NA or ACh. Manifest hemorheologic and hemocoagulation disorders attended by thrombohemorrhagic complications were revealed in this group of patients. (3) The effects of ATP, cyclic AMP, dibutyryl cyclic AMP on tracheal muscle responsiveness. Neither mitochondrial cytochrome P-450 concentration nor cholesterol side-chain cleavage activity varied with age or sex.

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Interdental sigmatism is associated with already existing open bite. Membrane-bound alkaline ribonuclease activity in chick embryo cells manifesting interferon-mediated interference. It was observed that all strains of mice treated with HSF during immunization with OA demonstrated enhanced production of hemagglutinating antibodies, as compared to animals treated with antigen alone. The viral load and subtype of hepatitis C virus (HCV) are predictors of the efficacy of interferon (IFN) therapy. The present study explored whether there are long-term changes in cognitive abilities in patients with galactosaemia and whether oral uridine can improve neurocognitive performance. The 2-3-fold variations in the RBE values for various parameters of the organ mass changes were registered at low doses, cardizem max daily dose whereas within the range of median and high doses under study, the differences were insignificant. Additional microfilaments are found to run from the peripheral cytoplasm to the perinuclear region.

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