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Indocin (Indomethacin)
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Indocin

Indocin is a non-steroidal anti-inflammatory drug, also known as an NSAID. It treats pain, inflammation, and swelling. Indocin works well for moderate to severe pain. It should be used carefully when taken long-term since it has some serious side effects.

Other names for this medication:
Artid, Artisid, Donica, Ducain, Edcin, Idicin, Indmecin, Indoc, Indocap, Indocid, Indoflam, Indol, Indomethacin, Indonet, Indopar, Indoriv, Inmecin, Inocin, Methadocin, Microcid, Recticin, Tissop

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Also known as: Indomethacin

Description

{name} is a nonsteroidal anti-inflammatory drug (NSAID).

{name} is used to treat moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis. This medicine is also used to treat shoulder pain caused by bursitis or tendinitis.

Extended-release {name} ({name} SR) should not be used to treat gouty arthritis.

Dosage

This section provides information on the proper use of a number of products that contain indomethacin. It may not be specific to Indocin. Please read with care.

For safe and effective use of this medicine, do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Using too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be used regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

Do not take rectal suppositories by mouth or use it in the vagina.

To use the suppository:

If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper. Remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum Remain lying down for about 15 minutes to keep the suppository from coming out before it melts. Make sure to wash your hands with soap and water before and after inserting this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppositories): For moderate to severe ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis: Adults and children older than 14 years of age—One 50-milligram (mg) suppository, inserted into the rectum up to 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For acute painful shoulder caused by bursitis or tendinitis: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 to 4 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For gout: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Indocin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Indocin overdosage: vomiting, migraine, lightheadedness, confusion, extreme tiredness, feeling of numbness, pricking, burning, creeping on the skin, convulsions, dyspepsia.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Indocin dosage information

Side effects

The most common side effects associated with Indocin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Indocin SR can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Indocin SR may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use Indocin SR if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

heart disease, high blood pressure; a heart attack, stroke, or blood clot; fluid retention; bleeding problems; stomach ulcers or bleeding; asthma; liver or kidney disease; or if you smoke.

If you are pregnant, you should not take Indocin SR unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

This medicine may temporarily affect fertility (ability to have children) in women.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Indocin SR is not approved for use by anyone younger than 14 years old.

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This case report clearly illustrates defined simultaneous cerebrospinal fluid leaks at the cervicothoracic and upper lumbar areas. Immunoheterogeneity of parathyroid hormone in parathyroid cysts: diagnostic implications. Increased volume of the denervated musculature may also accompany acute denervation signal changes. Human leukocyte interferon, prepurified either by acid ethanol extraction or by affinity chromatography with antibodies, was further purified by gel filtration in the presence of sodium dodecyl sulfate. During postnatal development, it is transiently expressed in the optic nerve fibers. The purpose of this study was to assess the oral health status and treatment needs of a Lebanese adult population. The clinical picture in all patients was characterized by dementia. The administration of c-AMP and DB c-AMP to six children with NDI has failed to yield an antidiuretic effect. The overall cost and quality of life assessment in endoscopic research has been limited and must be improved.

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Scanning electron microscopic observations and differentiation of eggs of the Anopheles dirus complex. Forecasting health personnel needs on the basis of long-term developmental trends in relation to the standardized results. Lymphocytes from strains of mice of the C57BL background (e.g., C57BL/6) are resistant while cells from other strains (e.g., 129 and DBA/2) are susceptible. Long-term clinical results after intervention using aorto-coronary bypass. The adsorption of IgG-coated SRBC to virus-infected cells was completely abolished if the tests were carried out in the simultaneous presence of rabbit antiserum elicited against CMV. Apart from the higher glucose intake during the second week, jaundiced infants principally differed from non-jaundiced infants by the development of significant hypophosphataemia. Cholestyramine enhances gallbladder emptying and plasma cholecystokinin responses to oral ingestion of a mixed meal. Sudden early diastolic anterior movement of the septum in endomyocardial fibrosis. The influence of coffee drinking as a possible risk factor for loss of bone mass was assessed in a cohort of 619 70-year-old men and women who were examined with dual photon absorptiometry of the right calcaneum. After a longer period of incubation, an additional cleavage site between Lys-146 and Gly-147 could be demonstrated.

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L 14655 had antimicrobial activity similar to that of cephalothin. 182 patients followed-up for different periods in the last 3 years were routinely monitored for serum T-PSA. Hydroxylation of diazepam (temazepam and oxazepam) led to a loss of, or a considerable reduction in, behavioural activity, whereas activity was preserved, though modified, by demethylation (nordiazepam). A family history of breast cancer reflects shared cultural factors, genetic predisposition, or both. The resistance of hepatocytes to the acute effects of insulin after exposure to dexamethasone alone and the potentiation of insulin action and decreased sensitivity to insulin after exposure to insulin plus dexamethasone are all mediated by post-insulin-binding events. It was shown that the histomorphology of the ancient Ostrea gigas shell is the same as that of the fresh one and both shells are composed of calcite.

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Glomerular localization of preformed immune complexes in nephrotoxic serum nephritis. The withdrawal of the drug was followed by a recurrence after 10 days of the papulopustular, follicular and pruritic lesions. We have reconstituted a minimal receptor.hsp90 assembly system containing four required components, hsp90, hsp70, p60, and p23 (Dittmar, K. The highest rate is observed in neonatal intensive care, where incidence density of catheter-related sepsis varies from four to 23 infections for 1000 catheter-days. Phenyllactic acid was also tested and was not blastomogenic under the same conditions.

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indocin dose gout 2020-07-15

Lymphocytes with surface IgM and/or IgD were present in blood at birth and the percentages over the first 6 months of life were increased compared to older monkeys. Our data confirm earlier observation that in evaluating the renal responsiveness to parathyroid hormone, urinary cyclic AMP is a better parameter than urinary phosphorus. Linear nevus sebaceous syndrome associated with choroidal hemangioma. A case of heterozygous familial hypercholesterolemia showing the regression of coronary atherosclerosis by LDL-apheresis. Insurance and the presymptomatic diagnosis of delayed-onset disease. Thyroid gland function after short-term administration of amiodarone and digoxin. The aim of this study was to determine and describe the role and functions of the community health nurse in the health services of local authorities of the larger cities within the framework of legislation regarding health and the health service structure of the Republic of South Africa. A patient with mitral stenosis and atrial flutter was found to have a normal diastolic closure rate (E to F slope). A 37-year- zithromax drug class old male developed a rapid increase in liver enzymes and cholestatic parameters after starting treatment with risperidone for paranoid psychosis.

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Content of free and protein-bound forms of glucocorticoids in patients with progressive Duchenne muscular dystrophy. Although beta-catenin was observed only at the cell-cell boundaries in four specimens, it was present in the nucleus and cytoplasm and at the cell-cell boundaries in the other 11, suggesting constitutional activation of the Wnt/Wingless signaling pathway in synovial sarcoma. The nodules developed by Rondo were ineffective in the presence of nitrates, and otherwise effective. Single-step growth analyses have shown that the hybrid phage gives a burst about two-thirds that of T7 or T3 on females and about one-half that of theolair 250 mg hond T3 on males. ERCP is indicated when a biliary complication is suspected after laparoscopic cholecystectomy.

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Both approaches have been successful in accounting for detection of simple translational displacements, but we examined how such models coped with more demanding stimuli. The dorsal aspect of the distal segment was further characterized by a cell rich area related to the entrance of the vinculum longum. It is probable that this massive and prolonged occupational exposure to the corrosive effect of NaOH mists induced irritation and burns to the respiratory system, eventually leading over the counter medicine similar to protonix to severe obstructive airway disease. Protective and bronchospasmolytic effect of ipratropium bromide in bronchial antigen challenge tests compared to other antiasthmatic drugs. Histological and roentgenological synopsis on the importance of lymphangiosis carcinomatosa for the occurrence of unilateral Kerley-B lines.

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Dynamic calorimetry revealed changes of the transitional process in 75 patients as compared with the control. To gain insight into the role of the limb deformity (ld) gene in limb morphogenesis, we examined the morphologic details of early embryonic limb formation in the mutant ld/ld mouse. The death-related cysteine proteases of the caspases family play a central role in the execution phase of apoptosis, and we recently reported the importance of serine protease activation in camptothecin-induced apoptotic endonuclease activation in HL60 cells. Beta-lipoprotein cholesterol: calculation without centrifugation and clinical importance. Response to additional autonomic tests (such as head-up tilt with or without venepuncture, and food challenge and exercise) was documented. Congenital Heinz body haemolytic anaemia due to haemoglobin Perth in a Nama child seemingly aggravated by the high nitrate content of the water supply. t-PA activity was measured in the cell media using the chromogenic substrate, S-2251. is well documented, the adoption of Hemofiltration (HF), has been, up to now scarcely considered. Serially arranged, orthogonal side branches that are suggestive of topographical representation of the serially arranged sensilla on the antennule contribute to the stratification of the LAN. In the last resort, however, any form of exercise is better than none at all, when it comes to lowering the coronary risk.

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In preparations of cirrhotic liver, as compared with liver from the intact animals, more distinct activation of glycolysis was caused by addition of ATP and NAD at the stage of 3-week intoxication and also by addition of hexokinase, glyceraldehydephosphate dehydrogenase and lactate dehydrogenase at the stage of distinct cirrhosis of liver (6 weeks of CCL4 intoxication). The development of thrombocytopenia and persistent hypoprothrombinemia precluded liver biopsy. Cultures from these lesions and of blood showed growth of Pseudomonas aeruginosa. Only a small nonsignificant inhibition of neutrophil function occurred in the absence of PAF. The localization of CB1 receptors in the spinal cord, spinal roots, dorsal root ganglion (DRG), and peripheral nerve of the rat flagyl and alcohol effects was determined. In situ staining in nu/nu mice detected the presence of wild-type p53 protein in residual tumor cells following rAAVp53 administration. We therefore hypothesized that the human homologue of the Clamydomonas dynein p28 gene would be an attractive candidate gene for patients with ICS.

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