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Klonopin (Clonazepam)
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Klonopin

Klonopin is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Klonopin works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Adnil, Almac, Anxiset, Calmnir, Cleps, Clonapax, Clonapik, Clonaxyl, Clonazepam, Clonoasig, Clonopam, Clonzy, Clozep, Clozipam, Clozorix, Convaclon, Dipwell, Easyfeel, Esitor, Jasoclam, Klopam, Lozep, Meloprax, Nozim, Onapil, Ozepam, Repam, Revozip, Somnotril, Zepamax, Zeptril, Zicam, Zozep

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Also known as: Clonazepam

Description

Clonazepam is used alone or together with other medicines to treat certain seizure disorders (eg, Lennox-Gastaut syndrome, akinetic, myoclonic, and absence seizures). It is also used to treat panic disorder. Clonazepam is a benzodiazepine that works in the brain to prevent seizures. Benzodiazepines are central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

Klonopin is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.

The efficacy of Klonopin was established in two 6-to 9-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IIIR category of panic disorder.

Panic disorder (DSM-V) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: palpitations, pounding heart or accelerated heart rate; sweating; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking; chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); fear of losing control; fear of dying; paresthesias (numbness or tingling sensations); chills or hot flushes.

The effectiveness of Klonopin in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Klonopin for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.

Overdose

Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Klonopin may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take Klonopin with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol or using street drugs during your treatment with Klonopin also increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol or use street drugs during your treatment.

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GTP stimulates fusion between homologous and heterologous nuclear membranes. Dynamics and morphological peculiarities of pigmentation in the external cornea after removal of the eye in larvae of Rana lessonae Camerano have been studied in situ depending on the developmental stage during prometamorphosis. Such possible controllability of toxic PMA efficacy through adaptation to various extraneous substances is likely to underline the need for differentiated assessment of progressive and regressive elements related to adaptive reaction. 136 unimmunised children aged 6 weeks to 23 months who lived within reach of the treatment centre. The condition of the patient remained without complications for more than 25 years, except for two episodes of rather severe respiratory infections. No significant differences were reported among the three markers according to multiple metastases and metachronous polyps. Pancreatic autotransplantation in the pig: variations in epigastric arterial blood supply. The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions. The object of this work was to study whether a correlation existed between the content of cytochrome d in different bacterial cells and the inhibition of their respiration by cyanide. We report a patient who presented with a bullous eruption and who was found to have T cell CLL.

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Treatment of castrated or intact males with testosterone activated their sexual behaviour and decreased the receptor density in the brain cortex. These NREs are absent from MMTV strains that cause T-cell lymphomas instead of mammary carcinomas. Stratification and the Mantel-Haenszel procedure, and unconditional multiple logistic regression were used to obtain relative risks according to levels of cigarette smoking. Although the complex inhibits tumor growth without undue initial toxocity, longer-term side effects glyburide 2 5 mg limit the use of the compound. This case report documents the unusual presentation of an antenatal ovarian torsion followed by auto-amputation of the ovarian tube complex, finally resulting in a free floating abdominal cyst.

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Guidance and management of the cancer patient by the physician and tumor center. Responses of renin release to different stimuli in essential hypertensive patients classified by WHO stage classification. Treatment with an aromatase inhibitor (anastrozole, 1 mg/day for 3 yr) in a boy previously operated on for a hamartoma causing precocious puberty and presenting with advanced bone maturation and nearly fused epiphyseal cartilages, slowed cartilage fusion consenting a higher final stature than expected (164.4 cm vs 158.4 cm). Epidemiology of cerebrospinal meningitis in the department of Seine from 1936 to 1956. Stimulation of imidazoline receptors inhibits proliferation of human coronary artery vascular smooth muscle cells. The question of whether NFP teachers need to be users is analyzed from historical and current perspectives, and four options are presented for organizing NFP services in multi-method settings. Gadopentetate dimeglumine in craniospinal magnetic resonance imaging: common uses and some potential pitfalls. Toxin-induced mediators such as interleukin I and Tumor Necrosis Factor have been incriminated in septic shock with multivisceral involvement. falciparum merozoites and schizont infected erythrocytes was evaluated by an in vitro assay.

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Weight gain was predictive of birth-weight, each kg increase in total weight gain resulting in about a 30g increase in birthweight. Course of pulmonary tuberculosis after interruption of pregnancy. The resistance of N50-4 cells to CLB was almost completely abolished by combination pretreatment yielding both GSH depletion and GST inhibition. Further characterization of corticotrophin releasing factor activity from a bronchial tumour. Experimental production of new zymodemes of Entamoeba histolytica supports the hypothesis of genetic exchange. Cross-reactions of virally and chemically induced mouse sarcomas: surface expression flonase generic strength of a common viral antigen. Coring of bacterial flagellar filaments using myosin subfragment 1. The patient had typical immunoglobulin deficiency, diarrhea, recurrent respiratory infections, Giardia lamblia in the stool, and lymphoid hyperplasia of the small intestine. Proliferative potential in pituitary adenomas: measurement by monoclonal antibody MIB-1.

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