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Lunesta (Eszopiclone)
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Lunesta

Lunesta is a sedative medication. It affects chemicals in human brain that may become unbalanced and cause sleep problems (insomnia). Lunesta is used to treat insomnia: it causes relaxation to help you fall asleep and stay asleep. EsLunesta may also be used for purposes other than those listed here.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Sumycin, Imdur, Lipitor, Pamelor, Famvir, Provigil

Also known as: Eszopiclone

Description

Lunesta is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class.

Lunesta is a white to light-yellow crystalline solid. Lunesta is very slightly soluble in water, slightly soluble in ethanol, and soluble in phosphate buffer.

Eszopiclone is formulated as film-coated tablets for oral administration. Lunesta tablets contain 1 mg, 2 mg, or 3 mg eszopiclone and the following inactive ingredients: calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin. In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.

Dosage

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take Lunesta only if you are able to get a full night's sleep before you must be active again. Never take this medication during your normal waking hours, unless you have at least 8 hours to dedicate to sleeping.

Take Lunesta with a full glass of water.

Avoid taking Lunesta within 1 hour after eating a high-fat or heavy meal. This will make it harder for your body to absorb the medication.

Lunesta is for short-term use only. Tell your doctor if your insomnia symptoms do not improve, or if they get worse after using this medication for 7 to 10 nights in a row. Do not take Lunesta for longer than 2 weeks without your doctor's advice.

You may have withdrawal symptoms if you stop taking Lunesta after taking it over several days in a row. Do not stop taking Lunesta suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Overdose

In clinical trials with Lunesta, one case of overdose with up to 36 mg of Lunesta was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Lunesta overdoses up to 270 mg (90 times the maximum recommended dose of Lunesta) have been reported, in which patients have recovered. Fatalities related to Lunesta overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Do not share this medication with others. It is against the law.

Side effects

The most common side effects associated with Lunesta are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Lunesta, tell your doctor if you are taking any of the following drugs: rifampin (Rifadin, Rifater, Rifamate, Rimactane); ketoconazole (Nizoral); or antidepressants, narcotic pain medications, muscle relaxers, seizure medications, or anti-anxiety medications.

This list is not complete an there may be other drugs that can interact with Lunesta. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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If substantial amounts of antimicrobials are incorporated into the biomaterial, release pattern and killing efficacy of each substance group has to be determined in order to reach bactericidal concentrations in the environment of adherent bacteria. The present study investigated whether the upright posture inhibits sleep by reducing baroreceptor firing. We postulate that the development of IUGR is related to smaller functional structure in the placenta. The aim of this article is to show how dysphonic voices can be characterized by means of a multivariate statistical analysis of flat vowel spectra. Plantar flexion was progressively performed in prone position against a scale. The two lower vertebrae (L4 and L5) appeared to be transitional toward the sacral region, whereas the upper two vertebrae (L1 and L2) were transitional toward the thoracic region. Of 4 surviving rats that experienced seizures, two developed long-lasting spastic paraparesis which remained unchanged for at least 3 months, whereas the other two were normal in behavior on the days following the administration. Cerebral MRI in neurological asymptomatic patients with malignant melanoma. Who would call one branch of medicine more necessary than another?. This dose was over two orders of magnitude lower than the threshold dose of the same PT preparation required to induce lymphocyte mitogenesis in vitro.

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This study identified several factors associated with anal sphincter tears. Reactions of being nervous and being upset by how other people acted when the bombing occurred accounted for about one-third of the total variation in posttraumatic stress symptom scores and thus were major predictors of posttraumatic stress. Review of the literature shows that the diagnosis, essentially based on X-ray examination, bonescan and arthrography, needs to be confirmed by histological examination. On the contrary, the antral motility was stimulated markedly by injection CCK-8-antiserum into LH, indicating that the endogenous CCK-8 in this area exercises a continuous restraint on antral motility in the basal state. Chest compression elicits extravagal neural reflexes which can alter the respiratory pattern. The high recurrence rate after surgical treatment can be reduced by the addition of radiotherapy. A 41-year-old man presented with progressive unstable angina pectoris during the last three hours.

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In the following article the scheme by Eikmann and Kloke systematizes this approach. These results indicate that high levels of negative air ions can have a significant impact on the airborne microbial load, and that most of this effect is through direct killing of the organisms. Photo-thermal mechanism appears to induce the skin lesions in the Yorkshire pig, whereas photo-thermal and photochemical mechanisms appear to be involved in lesion formation in the Yucatan mini-pig. Expulsions were more frequent at the beginning of the study and when the IUD was inserted more than 30 minutes after delivery of the placenta. Late results of treating children with bronchial asthma at Kislovodsk health resort. Ex vivo perfusion of intestinal allografts with anti-T cell monoclonal antibody/ricin A chain conjugates for the suppression of graft-versus-host disease.

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Evaluation of toxicity of various occupational factors based on the data of acid-base equilibrium. Factors such as zygosity and gestational age influence monitoring in twin pregnancies. Increase in alpha-glycerophosphate dehydrogenase and other oxidoreductase activities of hepatic mitochondria on administration of vanadate to the rat. Recent advances in resolution of two-dimensional echocardiography permit direct visualization of an aortic valve orifice from the transthoracic approach more easily than before. A proportion of the erythroblasts showed ultrastructural abnormalities.

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Sialomucoprotein content of the blood serum in rheumatism in conjunction with endemic goiter. Mechanical properties and wear behavior of light-cured packable composite resins. A decrease of CD4 positive cells was observed in the psoriatic group before therapy. Peculiar focal myocardial degeneration and fatal ventricular arrhythmias in a child. Centromeric probes for chromosomes 1, 2, 3, 4, 10, 12, and 17 and whole-chromosome paint libraries for chromosomes 1, 2, 3, 4, 8, and 12, in conjunction with analysis of G-banded metaphases, allowed the major portion(s) of these 10 PPC-1 marker chromosomes to be defined. The action of penicillin is, in general, to decrease chloride conductance in this preparation. Thirty-two neglected congenital dislocations of the hip in twenty-two children over the age of six years were treated by traction, open reduction and Chiari osteotomy.

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A single blind phase of two week periods of placebo, gallopamil 100 mg o.d. Eight pregnancies complicated by immunologic thrombocytopenic purpura are described and the literature is reviewed. In conclusion, synthalin A markedly affected islet morphology and stimulated glucagon secretion of isolated guinea pigs islets. Chromium supplementation did not markedly affect the performance of calves, but the Cr-nicotinic acid complex and CrCl3 did intensify the response to insulin administered i.v. After operations, the experimental specimens of 4 weeks and 8 weeks were examed histologically by light microscope and studied quantitatively by computer image analysis system. Significance of the clinico-anatomic form of tumor growth in the prognosis of lung cancer. These findings suggest that smoking and family history of EC are important risk factors for EC, and the alteration of P53 gene may be related to smoking and inherited factor. A breakthrough for treatment of acute leukemia with a vitamin A acid derivative. The latter were performed during hydropenia and continuous isotonic saline infusion. Infiltrating recipient mesenchymal cells form the obliterative airway disease lesion and dramatically remodel graft tissue in a model of chronic lung rejection.

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The interdependence between neurodynamic indices and the state of the hearing in blast trauma. We analysed specific IgG subclasses levels to Mycobacterium leprae sonicate extract (MSE), lipoarabinomannan B (LAM) and phenolic glycolipid I (PGL-I) in the sera of leprosy patients with different clinical manifestations. Beside the qualitative possibilities, a quantitative improvement is achieved in the mu eff-scale with significant better peak area reproducibility and equal to more precision in quantitative analysis than with the primary time-scale integration. An untreated long standing depressive condition appeared to be the major etiologic factor. A better understanding is required of the complicated effects of personality on CHD development.

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The T3 band which is located between T1 and T2 seems to be distinct from the soluble forms of tyrosinase. Hypochromic, sideropenic anemia in pregnancy--comments on diagnosis and therapy (proceedings). In this paper, we illustrate a logical approach to reaching a decision regarding which of two migraine treatments should be used in a clearly defined patient. Heart rate and oxygen uptake response to angiotensin in the squirrel monkey at 10 degrees C. Chondroitin 6-sulfate immunoreactivity extended from cone inner and outer segments to the adjoining interphotoreceptor matrix (IPM) surrounding the rods, but only background labeling was observed around the rods. this randomised open crossed study was conducted on 80 healthy menopausal female volunteers treated successively with 1.5 mg of estradiol per day in gel form (Estreva Gel, Theramex, Monaco) and by a transdermal matrix twice-weekly system delivering 50 micrograms/24 h of estradiol (Oesclim 50, Fournier, Dijon-France). Neoplastic cell preparations from four patients with clinically and morphologically well-defined leukaemic reticuloendotheliosis (LRE) were investigated for their capacity to synthesize immunoglobulin in vitro. Field evaluation of pesticides for their suitability in an integrated program for spider mites on pear. Sheep haemolysate was dispersed as fine droplets in a lecithin solution in dichloromethane to yield a W/O-type emulsion.

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Following nephrectomy the BP has remained normal without any therapy for 24 to 64 months. Course determinations of pH-value, serum O 2 - and CO 2 -tension in vaginal and abdominal gynecologic surgery. The amniotic epithelium has only a function as a semipermeable membrane for the diffusion of amniotic fluid. The c-AMP content was determined by combining the methods of Krishna and of Thomson and Appleman, and its turnover was estimated from the activities of adenylcyclase and phosphodiesterase using 3H-adenine. Disease-modifying drugs have been used, with the most recent approach being dietary modification in response to identifying arachidonic acid metabolites as possible contributors to the disease process. Regardless of how well trained, experienced and careful individuals are, if they handle radioactive materials often enough they will eventually have a contaminating incident. Four aneurysms were excluded with a transluminally placed endovascular graft made of a PTFE graft and two Palmaz stents (PTFE-EG), three were excluded with a tantalum-Dacron endovascular graft (TD-EG), and one was surgically treated with a standard PTFE graft (PTFE-Surg). Occupational asthma caused by inhalation of cuttlefish bone dust. The fine structure of the rod-bipolar synapse is described and illustrated.

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The location of positive cells and their pattern of labelling suggested that macrophages, fibroblasts and endothelial cells were the main cell populations expressing monokine genes. Qualitative complementation test for temperature-sensitive mutants of herpes simplex virus. Furthermore, DNA rearrangements are present in lymphocytes with phenotypic and functional characteristics of helper, killer, or suppressor T cells. We have examined the relationship between the number of nucleolar organising regions (NORs) present in 75 primary breast cancers and various clinical and pathological features known to be associated with prognosis in patients with breast cancer. Thyroid hormone stimulates synthesis of a cardiac myosin isozyme.

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Tuberculin skin reactivity four years after neonatal BCG vaccination. BSN students find a way to lessen the severity of reality shock. The capacity of stem cells of peritonium of mesodermal origin to undergo metaplastic transformation and form different tissues developed from mesoderm germ layer is exploited with ulterior motive to use it in the management of human diseases. The exogenous pathway of enzyme adsorption to fibrin fibers seems to represent an important thrombolytic mechanism. Effect of the action of rotary diamond instruments on the enamel and dentine. Effect of manual lymph drainage as described by Vodder on oedema of the hand after fracture of the distal radius: a prospective clinical study. Even in the absence of estrogen recptor, however, most tumor tissue examined contained a measurable amount of estrogen.

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This study was conducted to investigate whether citalopram alters plasma levels of oral theophylline amethopterin . By means of the test of inhibition of peritoneal macrophage adherence, the increased level of sensibilization of splenocytes towards tissue antigens was shown in mice hearing hepatoma 22a. As the substrates modified by these toxins are located in the mammalian cell cytosol, a catalytically active toxin polypeptide must reach this compartment in order to act. Fractures exposed to these levels of radiation all appeared to heal during the course of this experiment, although with varying degrees of delay, with the exception of those exposed to a single dose of 1100 rads 3 days after fracture. Eight patients were successfully weaned from this support, and 6 were discharged from the hospital. This type of band is observed both with thermal sources and with broadband light sources created by pulsed laser light, and it is observed only with s-polarized (TE-mode) light. The amygdalotomy was effective when the status was mild and the focus was circumscribed to the amygdala. Recommendations of the Polish Pthysiopneumonologic Society for diagnosis and treatment of chronic obstructive lung diseases.

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Influence of somatotropic extract on septicemia caused by Staphylococcus aureus in rabbits. 2 Sera containing antibodies against the nicotinic receptor blocked neuromuscular transmission in the phrenic-nerve hemidiaphragm preparation without affecting the muscle responses evoked by direct electrical stimulation. Fat-conserving blepharoplasty corrected skeletonization of the inferior orbital rim in 13 of 14 cases, and was moderately effective at correction of lower eyelid fat protrusion and wrinkles. These findings are discussed in the context of a systems approach to development in general, and to the development of children at risk in particular. Preoperative evaluation and management of the surgical patient with heart disease. Cross-sectional, case-control study in a large, suburban pediatric practice.

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Eccentric exercise of high intensity rather results in a mechanical stress to the fibres. The expression sites of DA D2 Rc mRNA led us to suspect other functions of DA in the placenta besides the regulation of human placental lactogen. Clinical, histologic, histochemical, immunopathologic, and electron microscopic studies of the depigmented lesions in seven patients with systemic scleroderma demonstrated changes similar to those of vitiligo, but with subtle differences. Neutralization of the anticoagulant effects of heparin with protamine (salmine). Its inhibitory activity was found to be reversible and unlikely to result from spermine. In conclusion, the epitope of type 1 anti-intrinsic factor autoantibodies is located in the 251-265 amino acid sequence of the protein. Butenafine provides rapid and persistent antifungal activity and symptom relief in patients with tinea corporis. The anodal edges of the cells underwent retraction of their plasmalemmal extensions, while the cathode edges and the longitudinal ends developed lamellipodia and ruffled membranes. As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas they are quite unnecessary in mouse brain.

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Two animal models of mutated N-ras expression resulting in myelodysplastic and myeloproliferative features maximum daily valium dosage are discussed. Difficulties encountered in gathering information on illegal abortion in the population of women. Tela subcutanea isolated by dissection exhibits an activity of 65 microl./mg. Left-sided traumatic diaphragmatic hernia involving solid viscera. Methylxanthines also accelerated the release of acetylcholine from the ileum associated with stimulation.

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The good predictability, an overall r2 value of 0.75, with such an approach is demonstrated. Their allergenic activity (IgE binding) was not lost during the purification steps. The pathological characteristics of this experimentally induced cerebral ischemia were those of multifocal cerebral infarction. The influence of patient-related factors and the position of the acetabular component on the rate of dislocation after total hip replacement. A man in the thunderstorm: coronary injuries and electric shock.

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Nalidixic acid does not induce auxotrophies of any sort in clinical isolates of C. salivary secretion, radial pulse, forearm sweat gland activity and distance to visual near point. Intra-abdominal injuries of the bowel, mesentery, and mesenteric vessels were found at laparotomy in two patients with nonpenetrating gunshot wounds of the abdominal wall. The animals, which succumbed, had acute necrotizing fibrinous pneumonia. This study investigated the role of preoperative chemotherapy in squamous cell cancer of the esophagus. The first fraction contained mainly lipopolysaccharide which possessed no enterotoxic activity measured by the fluid accumulation in the ligated rabbit ileal loop as well as no activity in the skin permeability test.

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Ligation of the hypogastric arteries in the treatment of massive hemorrhage in gyneco-obstetrics. Frequency with which physicians discuss with and offer HIV testing to prenatal patients. Atropine pretreatment of rats before stress corrected the epithelial pathophysiology. Different cohort formation criteria and variations in the follow-up modify the results of occupational mortality studies. The effects of long chain free fatty acids on human neutrophil function and structure. Propranolol and newer antihypertensive drugs in the management of hypertension. The presence of the two methyl groups reduced the half-wave reduction potential of DMM by about 70 mV, so we expected that its radiosensitizing ability would also decrease. Double product, frequency of breaths, and tidal volume were not significantly changed from (A) to (B). The pattern of abnormal vascular proliferations within this tumor were almost identical with telangiectasia. Classification of liver cancer according to TNM and its clinical use.

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An 18-year-old West Indian male presented with severe sternal pain and an exacerbation of facial acne. Translation of EMC-RNAP WAS SLIGHTLY Reduced if ribosomes from interferon-treated cells were used in the mixed cell-free system, confirming previous reports. The association of hepatitis and signs of hypersensitivity may suggest an immunoallergic mechanism of hepatotoxicity in some patients. A comparison of three methods for the diagnosis of sound, stained, and carious dentine: conventional, mechanico-acoustic, and laser-acoustic methods. 2-alpha-(N-Dansyl-4-aminophenylthio)-N-acetyl-9-O-acetylneuraminic acid (10) was prepared as a new specific and highly sensitively detectable sialate-9-O-acetyl-esterase substrate. An increased percentage release of proteoglycans from OA cartilage compared to N cartilage was apparent both shortly after collection of the cartilage and after culture.

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Electron microscopic study disclosed crystals resembling cholesterol and masses of autophagic vacuoles, many of them glutted with lipid, deposited within cells of the stratum corneum. The finding of a strong preponderance of left-sided strokes calls into question some widely held theories as to the cause of POS and implicates end-hole aortic perfusion catheters as a major factor. Shape and size of synaptic vesicles in different types of presynaptic profiles in the medial septal nucleus of the rat. In addition to evaluating L/S ratios, we performed an assessment of phospholipid concentrations in 17 pregnancies before and after administration of dexamethasone. Management, evaluation and technical support for rehabilitation projects need to take these essential characteristics into account. Postoperative neurologic deficits developed in three patients (11 per cent), and one of these died.

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The results of these dissections are presented together with comparisons of the data with that already available in the literature. von Willebrand factor (vWf) is synthesized as a large precursor that dimerizes in the endoplasmic reticulum and forms multimers in the trans- and post-Golgi compartments of megakaryocytes and endothelial cells. Complete preoperative knowledge of hepatic vascular anatomy should permit better selection of patients for potentially curative resection and avoid operation in patients with incurable tumors. The author is of the opinion that the case was an anastomosis between a. The intrinsic muscle pressures were significantly increased when the cast-brace was applied.

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Evidence is presented that these inclusions may contain desmin, the intermediate filament type characteristic of muscle. Simple transfusion is used to increase oxygen-carrying capacity. No PHI, LDH or CA variants were found among the Land or Sea Dayaks. Head injuries in the pediatric emergency department: a 5-year experience at the Pediatric Clinic of Modena. Even 18 to ultram 100 mg tablets 24 hours after administration, the systolic blood pressure was reduced on average by 20 mmHg, the diastolic pressure by 14 mmHg. Blood culture was positive for Haemophilus influenzae only, in 15 patients. The pathologic reaction was supported by a distinct and pronounced granulomatous inflammatory response. The data of the clinical and electromyographic examination of two M. We have purified the human type C adenovirus E1A 13S mRNA gene product, expressed in Escherichia coli, and demonstrate that the protein exhibits genuine viral functions upon microinjection into mammalian cells.

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These genes show a high level of identity with each other at both DNA and amino acid levels. Protective effects of cyclohexyladenosine following cerebral ischemia in the gerbil hippocampus. Engineering and characterization of a novel fusion protein incorporating B7.2 and an anti-ErbB-2 single-chain antibody fragment for the activation of Jurkat T cells. From 12 cases managed by surgery, the excellent results were achieved in 9, good in 2 and bad in 1 patient, respectively. Combination of immunological and lectin reactions in affinity histochemistry: proposition of the term affinitin. Contrary to earlier beliefs, this tumor does not arise from the synovial lining of joints and bursae, but develops from pluripotential mesenchymal cells through abnormal differentiation into synovial neoplasms. A method is described for the isolation of nuclei from an side effects of amaryl medication axenic strain of Dictyostelium discoideum using a sorbitol/Ficoll solution and low concentration of Triton X-100. Prevalence and intensity of helminth infections (egg counts/g stool) of Ascaris lumbricoides, Trichuris trichiura and hookworms significantly fell in the 2 groups receiving anthelmintic treatment and there were some reductions in the 2 groups not receiving anthelminthic treatment. Intracellular deoxyribonucleotide pools were examined before and after thymidine treatment in highly sensitive T-lymphoid cells, relatively resistant B-lymphoid cells and moderately sensitive melanoma cells.

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