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Skelaxin (Metaxalone)

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Skelaxin is a muscle relaxer used to treat muscle pain and discomfort that is not chronic or long-lasting. The typical dose for adults and children over 12 years old is 800 mg three to four times a day.

Other names for this medication:
Fenaplus, Flexura, Metadol, Metaxalone, Mobiswift, Skeltab

Similar Products:
Levaquin, Phenergan, Priligy, Geodon, Theolair, Celebrex

Also known as: Metaxalone


{name} (metaxalone) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain.

{name} is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.


Usual Adult Dose for Muscle Spasm:

800 mg orally 3 to 4 times a day.

Usual Pediatric Dose for Muscle Spasm:

>= 12 years: 800 mg orally 3 to 4 times a day.

Detailed Skelaxin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of metaxalone can be fatal.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Skelaxin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Skelaxin if you are allergic to metaxalone, or if you have:

anemia (low red blood cells); severe kidney disease; or severe liver disease.

To make sure Skelaxin is safe for you, tell your doctor if you have liver or kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether metaxalone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Skelaxin is not approved for use by anyone younger than 12 years old.

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Electrocardiographic picture of the right-bundle branch block with intermittent left-anterior and left-posterior hemiblock (intraventricular trifascicular block). Codependency: a concomitant field of interest in research into the phenomenon caring. This P450 did not catalyze the hydroxylation of either hexobarbital or testosterone. Effect of hydrocortisone on the rat mammary gland in organ culture. Critical residues which diminished antigen recognition by 1000 to 10,000-fold in molar terms were identified in both N15 Valpha (alphaE94A or alphaE94R, Y98A and K99) and Vbeta (betaR96A, betaW97A and betaD99A) CDR3 loops.

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The effects of anorexia nervosa on skin thickness, skin collagen content and bone density were investigated in a cross-sectional study of 36 women with anorexia nervosa with a 4-year median duration of amenorrhoea and compared with a group of 33 women of comparable age without anorexia and with normal periods. Displacement of bound unactivated FVIII from the platelet surface occurs when vWF is added to the FVIII-platelet complex. The main characteristic seen in sialograms is irregular dilation of the main and branching ducts. Proposed mechanisms suggested the involvement of peroxyl radicals and prostaglandin H synthase for the biotransformation of retinoids. The MRTF was low pass in character having a corner frequency of 100-120 Hz.

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Smokers have been shown to have increased risk of intraoperative pulmonary complications and of a wide range of postoperative complications, but an increased risk of postoperative intensive care admittance has not yet been described. Passing the oral examination for specialist qualification in psychiatry: Part II. Identification of endonuclease activity in HIV-1 gp120 preparations produced using baculovirus expression systems. Intramembranous particles and chlorophyll complexes in chloroplasts. Pars plana vitrectomy with implantation of silicone oil in surgery forvery large retinal tears. Detection of soft-tissue and skeletal infections with ultra low-field (0.02 T) MR imaging. A radical neck disection revealed metastases to lymph nodes, to spinal chain and residual tumor infiltrating the parotid gland. There was an abnormal increase of 5-hydroxyindolacetic acid in the cerebrospinal fluid after probenecid test, suggesting an increase of the turnover of 5-hydroxytryptamine during periodic hypersomnia. Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.

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To examine the role of angiotensin II in the maintenance of blood pressure and the control of aldosterone secretion in man, eight normal subjects were studied on a tilt table in sodium replete and sodium depleted states prior to and subsequent to the intravenous infusion of an angiotensin converting enzyme inhibitor (CEI). Light microscopic immunohistochemistry of the glial fibrillary acidic protein (GFAP) and S-100 protein did not stain a layer corresponding to the extracellular matrix and synapses but showed an intensely positive reaction immediately outside this layer. Measurement of tidal lung volumes in neonates during high-frequency oscillation. Effect of (-)nicotine on GABA efflux from guinea pig cerebral cortex slices. The CTCL generated from activated synovial T lymphocyte populations in RA may be used to assess the functions of these cells and their responses to regulatory factors. Deleterious effect of sodium fluoride on gastrointestinal tract. To describe the dynamic structures of a protein, the core regions moving with strong positive or negative correlations to other regions of the polypeptide chain are detected from the correlation maps of the movements of residues. Professional issues in the institutional treatment of delinquent children. Ectopic ICER expression induces remarkable modifications in AtT20 morphology.

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Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor. Dilatation and curettage revealed abundant avillous cytotrophoblast and syncytiotrophoblast with marked atypia, diagnostic of choriocarcinoma. Tyrosine nitration as a mechanism of selective inactivation of prostacyclin synthase by peroxynitrite. Included in this series is the newly prepared 7,8-difluoro-1,3-dimethyl-5-ethyl-5,10-dihydroalloxazine. Verification of the technique and models was performed by comparing measured frequency response data with graphs created by PSPICE modeling. The intermediate mammary cell populations are characterized as either alveolar hyperplasias or ductal hyperplasias.

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Expression and localization of platelet-derived growth factor ligand and receptor protein during acute and chronic rejection of rat cardiac allografts. Survival after phagocytosis by polymorphonuclear leukocytes was found not to be unique to gonococci, and it is suggested that continual phagocytic recycling minimizes the significance of this occurrence. Intravenous continuous infusion of PYY at doses ranging from 50 to 200 or intravenous bolus infusion of PYY at doses ranging from 50 to 200 showed a tendency to prolong the first cycle of the duodenal MMC and significantly shorten the second cycle. We have studied the incidence of thyroid tumours occurring after cancer in childhood in a cohort of 592 children treated before 1970. Discriminant--analytical investigation on the structural dependence of hyperglycemic and hypoglycemic activity in a series of substituted o-toluenesulfonylthioureas and o-toluenesulfonylureas.

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To further examine this potential relationship, human cell lines expressing ataxia telangiectasia (AT)-mutated dominant-negative fragments, which fail to arrest in S phase in response to ionizing radiation (IR), and AT cells expressing AT-mutated-complementing fragments, which regain the ability to arrest replicative DNA synthesis in response to IR, were analyzed for radiation-induced RPA phosphorylation. The antibody response of rabbits to a single injection of type I pneumococci. Rhesus monkeys develop agglutinating and complement-dependent antisperm antibodies after vasectomy. The vesicle is aspirated into a pipette and a constant point force is applied at the opposite side in motrin dosage chart the direction away from the pipette. Special problems of radiation protection in research institutes and technical plants. Low incidence of tumourigenicity in agarose colonies from spontaneous murine mammary tumours.

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A new surgical concept for repair of congenital clefts of lip and palate. The lesion remained therapy-resistant for aminoglycoside antibiotics. Its effects on Phase I and Phase II enzymes of carcinogen metabolism in primary cultures of rat and human hepatocytes have been investigated. One uncloned variant that produced cancers with a glandular component, MCF10CA1h, was cloned and cells were injected into mice. Histological and ultrastructural characteristics of interface membrane around aseptically loosened prostheses. Their motor performance was fair and autonomic regulation showed a good recovery over first 10 days. Peroxisome-like organelles which react positively to diaminobenzidine, the reaction being partially inhibited by aminotriazole, were identified in both protozoa. Occurrence of neutralizing antibodies against influenzavirus B in the population of Berlin (GDR).

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Role of the distal hinge region of C1-inhibitor in the regulation of C1s activity. Careful fundus examination was carried out with indirect ophthalmoscopy, slit-lamp biomicroscopy and ultrasonography. However, indexes remained generic name of vantin significantly elevated up to 17 days in the group receiving weekly milk instillations. New directions and societal responses to aging: a symposium in honor of Ollie A. IP was evaluated by studying urinary excretion for 5 hours after a test meal containing lactulose, L-rhamnose and xylose in water. The class II gene products, HLA-DR3 and DR4, may be the primary susceptibility genes for IDDM. We report the molecular characterization of seven new keratinocyte transglutaminase mutations (R315C, S358R, V379L, G473S, R687C, deletion Delta679-696, R127Stop) found in lamellar ichthyosis patients.

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The tumor metastatic to the axilla exhibited intracellular virus-like particles similar to those described in adenocarcinoma of breast and other sarcomas. However, F1 harbors some characteristics different from that of Calf thymus F1. The question arises of whether a periaqueductal gray nucleus retroambiguus-spinal cord projection also exists in the rat. Plasma amino acid concentration began to increase 60 min after the meat meal, when hyperfiltration was present. In vivo effects of estrogens on c-erbB-2 oncoprotein levels in chorionic villous tissue and maternal serum. Significant reductions in myocardial contractility both of the right and left cavities with a rise in the intensity of an inflammatory process suggest the leading role of a toxic and infectious agent in myocardial damage. Similarly, cigarette smoking is associated with an immediate increase in 8-epi-PGF2alpha and a quick drop after quitting. The effect of oral BV-araU was tested in cutaneous model infections of shaved Balb/c mice with herpes simplex virus type 1 (HSV-1). We have studied the transcriptional behavior of the mouse mammary tumor virus long repeat (MMTV-LTR) promoter during a prolonged exposure to glucocorticoids. The approximate equality of effectiveness of nitric, sulphuric and cyclamic acids to hydrochloric acid is attributed to the presence of chloride ion in the duodenal contents.

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LPS protected OprF from heat modification and trypsin degradation and facilitated the reincorporation of purified OprF into an artificial lipid bilayer without affecting its pore-forming activity. Changes in acute phase reactants, serum immunoglobulins and complement during the development of gingival inflammation. A case of small cell anaplastic epidermoid norfloxacin brand name company carcinoma of the esophagus is reported. A careful uptitration of dosages is achievable with a low rate of side effects. However, even if the in vitro LI leads to a certain underestimate, it can provide useful data. During melt pelletization in a high shear mixer the solubility of the drug in the molten binder strongly influences the pelletization process. Noise covariance incorporated MEG-MUSIC algorithm: a method for multiple-dipole estimation tolerant of the influence of background brain activity.

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Biochemistry and enzyme induction in MC-29 virus-induced transplantable avian hepatoma. In recognition of the centennial of the American Society for Microbiology. The growth cones of identified motoneurons in embryonic zebrafish select appropriate pathways in the absence of specific cellular interactions. The aim of this paper was to assess the influence of low power infra red laser radiation on blood flow in patients with atherosclerotic disease of the lower limbs. A series of five experiments was conducted with young male albino rats to investigate effects of various levels of dietary Ca, P and Mg on urinary cAMP excretion and kidney calcification. Evaluation of the MAP1b ELISA for the diagnosis of heartwater in South Africa. Serotonin-like immunoreactivity was mapped in the central nervous system (CNS) of the cockroach, Periplaneta americana. Thus, in the arcuate nucleus of female rats, varying circulating levels of estrogen give rise to a reversible reduction in the number of axo-somatic GABA synapses, together with a changing ensheathing of neuronal somata by astrocytes. Biotinidase deficiency: a congenital metabolic disease which can periactin medication generic be successfully treatment with vitamin H. No evidence of mutagenic/carcinogenic activity due to WHR-1142A, lidamidine hydrochloride, was found in any of the 4 tests.

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A competitive protein binding radioassay for 17alpha-ethynylestradiol in human plasma. Atrial myocyte sarcolemma was also more reactive than previously reported in rat atrial myocytes. Biosynthetic human insulin in comparison with conventional intermediary insulin from cattle. Steady-state mRNA levels were determined by Northern and dot blot analyses of total cellular RNA hybridized with cDNA probes specific for fibronectin, procollagen alpha 1III, and procollagen alpha 1I. Inbreeding, lymphoma, genetics and morphology of the Papio hamadryas colony of Sukhumi. Glycogen phosphorylase is richly represented in ABRM fibres and this detection is in opposition with the negative detection of alkaline phosphatase activity. Endosulfan administration (po, 15 and 30 days at 7.5 and 10 mg/kg body wt respectively) inhibited the activity of microsomal mixed function oxidases in kidney tissue of male rats. Giant T-wave inversion in patients with acute coronary insufficiency.

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Better performances were obtained in June than in mid-winter with reference to letter cancellation and random number addition tests. Mealtime assistance of an infant with cerebral palsy and a cleft of the soft palate: in bottle feeding and weaning. A quantitative papergram assay method for prednisolone in tablet for mulations. There is very little in the literature on nursing implications regarding the newer casting materials. Indeed pigeons tested with the herringbone illusions are deceived to a stronger extent with the right eye. Three zofran in pregnancy dose patients had osteogenic sarcoma diagnosed, one with myelodysplastic syndrome, one with colon carcinoma, and one with a soft tissue sarcoma. Numerous tachyzoites, ultrastructurally indistinguishable from Toxoplasma gondii, were found in lesions. The distance from the skin to the epidural space in a Chinese patient population. Platelet satellitosis and other in vitro changes induced by EDTA. In the present study a possible role of this nuclear gene in the transmission of mtDNA from various respiration-competent mutants was studied.

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Heat shock proteins may, in some cases, cause cross-reactivity between B. Effect of the somatostatin analog, octreotide, and of other hormones on the release of the acid-labile subunit of the 150 kDa complex by rat hepatocyte in primary culture. The patterns comprised linear, quadratic, cubic, and quartic mathematical functions and varied in spatial complexity. At this institution we have introduced combined non-operative and orthotic treatment for ruptured tendo Achillis. Proportionately more lives of persons with cardiac arrest were saved in the paramedic area than in the MET area. Radioiodination of chicken luteinizing hormone without affecting receptor binding potency. Field-scale preferential transport of water and chloride tracer by depression-focused recharge. Group A had epilenticular IOL implantation with pars plana lensectomy. Severe infection is treated by chemotherapy and bladder irrigations.

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