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Symmetrel

Symmetrel is a dopamine agonist that treats Parkinson's disease. It works by increasing the amount of dopamine, a chemical messenger in the brain which regulates body movements. It also has an antiviral property.

Other names for this medication:
Amantadine, Amantral, Amantrel, Comantrel, Neaman

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Also known as: Amantadine

Description

Amantadine is an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. Amantadine is also used to treat stiffness and shakiness caused by certain medicines that are used to treat nervous, mental, and emotional conditions.

Amantadine is also an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A). It may be given alone or together with flu shots. Amantadine will not work for colds, other types of flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain amantadine. It may not be specific to Symmetrel. Please read with care.

For patients taking amantadine for Parkinson's disease or movement problems (including dyskinesia) caused by certain medicines used to treat nervous, mental, and emotional conditions:

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide or patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. Improvement in the symptoms of Parkinson's disease usually occurs in about 2 days. However, in some patients, this medicine must be taken for up to 2 weeks before the full benefit is seen.

For patients taking amantadine to prevent or treat flu infections:

Talk to your doctor about the possibility of getting a flu shot if you have not had one yet. This medicine is best taken before exposure or right away after exposure to people who have the flu. To help keep yourself from getting the flu, keep taking this medicine for the full time of treatment. Or if you already have the flu, continue taking this medicine for the full time of treatment even if you begin to feel better after a few days. This will help clear up your infection completely. If you stop taking this medicine too soon, your symptoms may return. This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your doctor. If you are using the oral liquid form of amantadine, use a marked measuring spoon, oral syringe, or medicine cup to measure each dose correctly. The average household teaspoon may not hold the right amount of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing. You may take this medicine with or without food.

Take Osmolex ER™ extended-release tablet in the morning. Swallow whole. Do not crush, open, or chew it.

Do not receive the nasal flu vaccine (live attenuated influenza vaccine) while taking this medicine.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor. For oral dosage forms (extended-release tablets): Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor. For oral dosage forms (liquid-filled capsules, syrup, and tablets): Adults—100 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Older adults—At first, 100 milligrams (mg) once a day as a single dose. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For the treatment or prevention of flu: For oral dosage forms (capsules, syrup, and tablets): Adults—200 milligrams (mg) or 4 teaspoonfuls once a day as a single dose. Older adults—100 milligrams (mg) once a day as a single dose. Children 9 to 12 years of age—100 milligrams (mg) or 2 teaspoonfuls 2 times a day. Children 1 to 9 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 4.4 to 8.8 milligrams (mg) per kilogram (kg) of body weight per day. The dose is divided evenly and given 2 times a day. However, the dose is usually not more than 150 mg per day. Children younger than 1 year of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Symmetrel and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Symmetrel dosage information

Side effects

The most common side effects associated with Symmetrel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of Gocovri® and Osmolex ER™ in the pediatric population. Safety and efficacy have not been established.

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On the formation of crystal proteins during sporulation in Bacillus thuringiensis var. A third pathway utilizes both ubiquinone and cytochrome b and is partiayly inhibited by either thenoyltrifluoroacetone or antimycin A. Radiotherapy was employed in 60 patients, symptomatic treatment--in 10 patients with pancreatic cancer, 9 of them had the disease in stage III. Intercellular relay interactions in normal explant morphogenesis. Precocious puberty in a girl with congenital hypothyroidism receiving continuous L-thyroxine-replacement therapy. To determine the histochemical localization of asparagine-linked oligosaccharides of glycoproteins in a series of different mammalian and avian tissues, the effects of digestion with N-oligosaccharide glycopeptidase upon certain lectin-peroxidase-diaminobenzidine reactions of the histological structures involved have been studied by light norvasc tablet microscopy. Effect of PEEP ventilation on renal function, plasma renin, aldosterone, neurophysins and urinary ADH, and prostaglandins.

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Clinicopathologic correlation and pathogenesis of ocular and central nervous system manifestations in Hallervorden-Spatz syndrome. Cellulose acetate electrophoresis of alkaline phosphatase isoenzymes in human serum and tissue. Cystoid macular edema was present in five eyes, retinal phlebitis in two eyes, and retinal detachments in four eyes. The legislation and its interpretation by the courts emphasise a particular approach to private hospital planning which does not necessarily address the problems faced by consumers of hospital services in Victoria. PTLD occurs with greater frequency in pediatric thoracic organ transplant recipients than in the adult transplant population. Expression and aggregation of recombinant alpha A-crystallin and its two domains. Following EchoGen administration, prostate blood vessel image plavix 75 mg dosage enhancement was noted in all patients, and there were no adverse reactions during or after EchoGen administration with the dose employed. Cetuximab is the most developed one and there is plenty information on the literature about its current status.

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