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Valium (Diazepam)

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Valium is a benzodiazepine (ben-zoe-dye-AZE-eh-peens). It affects chemicals in the brain that may be unbalanced in people with anxiety. Valium is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Valium is sometimes used with other medications to treat seizures. Valium may also be used for purposes not listed in this medication guide.

Other names for this medication:
Almpose, Alpazepam, Anxol, Calmod, Calmpose, Calmtack, Camrelease, Depresom, Depsonil, Diaclam, Diaze, Diazecalm, Diazeco, Diazepam, Direc, Dizapam, Dizep, Elcion, Elpam, Elpose, Imilor, Imlor, Juniz, Karpam, Lakpam, Neomesmar, Nindral, Nupose, Osopose, Paxum, Peacin, Placidox, Ralium, Silprex, Sleecalm, Sparlium, Valrelease, Verzepam, Zeopse, Zycalm

Similar Products:
Diamox, Zyprexa, Coreg, Viramune, Caverta, Addyi, Zyvox

Also known as: Diazepam


Diazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam injection is also used to treat a seizure emergency called status epilepticus.

Diazepam injection is sometimes used as a sedative to help you relax before having surgery or other medical procedure.


Take Valium exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Valium may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Valium should be used for only a short time. Do not take this medicine for longer than 4 months without your doctor's advice.

Do not stop using Valium suddenly, or you could have increased seizures or unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Call your doctor at once if you feel that this medicine is not working as well as usual, or if you think you need to use more than usual. While using Valium, you may need frequent blood tests at your doctor's office.


Seek emergency medical attention. An overdose of diazepam can be fatal. Overdose symptoms may include extreme drowsiness, loss of balance or coordination, limp or weak muscles, or fainting.


Store at room temperature away from moisture, heat, and light. After you have stopped using this medicine, flush any unused pills down the toilet.

Keep track of the amount of medicine used from each new bottle. Valium is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Valium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


If Valium is to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be employed - particularly with known compounds that may potentiate the action of Valium, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants.

The usual precautions are indicated for severely depressed patients or those in whom there is any evidence of latent depression or anxiety associated with depression, particularly the recognition that suicidal tendencies may be present and protective measures may be necessary.

A lower dose is recommended for patients with chronic respiratory insufficiency, due to the risk of respiratory depression.

In debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation (2 mg to 2.5 mg once or twice daily, initially, to be increased gradually as needed and tolerated).

Some loss of response to the effects of benzodiazepines may develop after repeated use of Valium for a prolonged time.

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A retrospective review of the first 2 years of clinical results from a diverse group of orthopedic surgeons using this device at a Canadian University center may provide some insight into potential clinical outcomes in general use. Surface densities of both elements were significantly less on the conformable than on the conventional catheters. Cells lining the lumen of small cysts expressed CK14, CK17, and involucrin, and those in larger cysts showed a positivity for CK1, CK4, CK10, CK14, CK17, and involucrin. The three techniques allow differentiation between reactions produced by the materials, but a poor correlation exists between the results from the different techniques. We report on an 18-month-old boy with an interstitial deletion at 10q23.2-q24.1. The molecular mass of AQN-1 was determined by time-of-flight plasma-desorption mass spectrometry. The importance of the detection of lymphocytic clones for diagnostic purposes is illustrated by selected examples of former misnomers. This study establishes that guinea pig liver cytosolic beta-glucosidase generates a common glucosyl-enzyme intermediate from a variety of aryl beta-D-glucoside substrates and that the intermediate can react with various acceptors to form distinct products at rates which are dependent on the structure, nucleophilicity, and concentration of the acceptor. The therapeutic indications and clinical response are discussed. We conclude that the peripheral lesion of collagen lung stimulates the peripheral c-fiber receptors, leading to cough variant asthma.

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Early morning basal blood-spot and serum samples, and post-ACTH serum samples for 17-OHP measurement were collected from twenty-seven patients with precocious pubarche, hirsutism and/or menstrual abnormalities (age: 3 to 17 years). Evaluation of the release of mutagens and 1-nitropyrene from diesel particles in the presence of lung macrophages in culture. In the RT group, startle was not affected by the CS, and baseline startle was reduced from Session 1 to Session 2. The difference in the mean total gross tubal burn produced by the 2 methods is not statistically significant. Subjects who received amphetamine showed significant increases in systolic and diastolic blood pressure and reduction in end-tidal carbon dioxide. Corneal and conjunctival toxicity with low-dose cytosine arabinoside. Fresh autogenous grafts and osteochondral allografts for the treatment of segmental collapse in osteonecrosis of the hip.

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This patient regained consciousness but was found to be paraplegic and died from bowel infarction related to peritoneal rewarming without adequate perfusion. Signaling through beta-catenin is regulated by modulating its degradation and nuclear translocation. Depression of testosterone secretion in male patients with respiratory failure. Phylogenetic analyses by parsimony and maximum-likelihood methods showed Besnoitia to be reproducibly the sister group to a clade containing Hammondia, Neospora and Toxoplasma. The preliminary specifications for LSCT are as follows: scan speed is within 10 sec for a 40 cm length with a 1 cm slice thickness, and the absorption dose for lung is less than 1 cGy. This temperature-induced fusion of unilamellar vesicles is concentration dependent and can be abolished at lower total phospholipid concentrations. The effect of different chemical and physical agents on the viability of Cysticercus bovis: a preliminary report.

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This study recalls that some teratogens may be implicated in the pathogenesis of CDH, and also that PH, which was also present in treated fetuses without CDH, could be the cause rather than the consequence of CDH. The design of some new compounds to block psychotomimetic drugs. Posttraumatic true aneurysm of the left ventricle caused by a shotgun wound. A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. Immunoglobulin A, phenytoin, and protein were determined in plasma, unstimulated and stimulated whole saliva and stimulated and unstimulated parotid saliva from seizure subjects, aged 18 or more, who had ingested phenytoin for 1 year or more from controls. Treatment of seeds with the herbicide safener fluxofenim increased the total GST activity extracted from T. Cerebrospinal fluid concentration of cyclic AMP in cerebrovascular diseases. Phase contrast microscopic observation of the urinary sediment has to be performed on freshly collected urine.

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This suggests that acetylcholine initiates release of vasoconstrictor prostanoids as well as NO from vascular endothelium. Occurrence of high levels of di-(n-3)polyunsaturated fatty acid species. There is still too little well-documented evidence concerning the beta-blocking activity of the unidentified major metabolites of propranolol to suggest any alteration in the dosage regimen used in renal failure. High-dose epirubicin in locally advanced operable noninflammatory breast cancer: a feasibility trial. Persistent high titer of IgM is associated with several diseases, particularly neuropathies. The CD and ORD spectra cannot be interpreted in terms of tertiary structure probably due to carbohydrate contributions. There is evidence that widespread microvascular thrombus deposition may occur as a consequence of stasis in patients undergoing PHCA and that this might result in vascular occlusion and end organ damage. Time differences between elevation of muscular oxygen tension and increase in painfree walking distance during treatment of severe intermittent claudication with ancrod. The use of these in vitro and in vivo model systems provides new evidence that FGF, although unable to initiate neurogenesis on its own, is required for neural induction as well as for posteriorization. Interconversion of testosterone and androstenedione in the human testis: a comparison between the activities displayed by the interstitium and the seminiferous tubules.

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The first were aggregates of filaments, approximately 80-100 A in width, arranged in small bundles. During the last 7 days, the rats maintained a reasonably stable equilibrium level of 3 ejaculations per day. In the SST the patients are stimulated by hypoglycemia, thyrotropin-releasing hormone, and gonadotropin-releasing hormone after which growth hormone (GH), thyroid stimulating hormone (TSH), prolactin (PRL), luteinizing hormone (LH), and follicle stimulating hormone (FSH) are measured at frequent intervals. The effect of ACTH and cortisone on the carbohydrate-protein complexes of different types of epithelium in relation to their embryological origin. Colostral antioxidants: separation and characterization of two activities in human colostrum. The 1976-77 influenza season and results of laboratory studies (comparison of antibody studies by SRH and HI tests in sera from healthy subjects). Complete replacement of the ascending aorta and the aortic valve with coronary reimplantation. The mode of presentation, management and outcome of thirty-two patients referred to a hepatobiliary unit over a seven year period were analysed. These results provide indirect evidence, that cells contributing to the aortic arches and the septum of the truncus arteriosus in mice are derived from the neural crest.

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Rifampicin resistance mutations which altered the structure of RNA polymerase change the rate of adaptation of spoT cells to minimal media, especially to those containing serine at high concentrations. TACE in the treatment of carcinoma of the prostate: an 80-month surgery. In contrast, we have found that in the slow anterior latissimus dorsi (ALD) muscle, filamin was additionally located throughout the l band as judged by immunofluorescence with affinity-purified antibodies on myofibrils and cryosections. BDNF mRNA is expressed at high levels in hippocampus and BDNF serves as a trophic factor in primary cultures of rat hippocampus. The case for the F-to-U transformation is less strong than for the B-to-Y transformation because the wild-type lineages of F and U are very similar. Both arrhenotokous and thelytokous reproduction are known to occur in the parasitoid wasp Venturia canescens. Previous knowledge of the anatomical course of unmyelinated (C) axons along a peripheral nerve has been scarce and has led to the concept of the axons in a constantly interchanging position. Synaptosomes contained half the lactate and glutamine of cerebrum. Follow-up VA was compared with preoperative VA for the 58 study eyes and correlated with preoperative PRVEP parameters. Rapid enumeration of Fecal Coliforms in water by a colorimetric beta-galactosidase assay.

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Evaluation of an enzyme-linked immunosorbent assay (ELISA) for the detection of HbsAg. An autopsy case with ultrastructural and immunopathological studies. Stroke subtypes among Chinese living in Hong Kong: the Shatin Stroke Registry. On the right chromosomal arm three regions, a 70.6 kb region between the MSB2 and the KSS1 chromosomal markers and two smaller regions dominated by the KRE11 marker and another one in the vicinity of the SER2 marker were sequenced. Transport via the Dct system was vanadate insensitive, and in uncoupler titrations with intact cells, the decrease in the rate of succinate transport correlated closely with the fall in membrane potential but not with the cellular ATP concentration, implying that the proton motive force, rather than ATP hydrolysis, drives uptake. Changes in the antigenic composition of the lungs in experimental berylliosis.

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Renal biopsies showed active proliferative changes, and subendothelial deposits were frequently seen. The most characteristic feature of the precyst is a clump of mitochondria in the cytoplasm. Three hundred and forty eight cases of bites by adult Bothrops jararaca (group A) were admitted to the Hospital Vital Brazil between 1975 and 1984. Mean serum level of carbamazepine was 9.3 microng per milliliter with a suggested therapeutic range of 8 to 12 microng per milliliter reached by eventual doses of 16 to 20 mg per kilogram. A single study in 1993 using the in vitro rat hypothalamic slice preparation suggested that serotonergic modulation of circadian rhythms at the level of the suprachiasmatic nucleus was acting via the newly discovered 5HT7 receptor subtype. The removal of the left ovary determines a modification of the hormonal environment in the hen, as indicated by the structure of the regenerat frequency observed. Furthermore, we found high c-myc score values in three patients with RAEB and in two patients with RAEB-t during the ANLL phase which was diagnosed six to ten months after the initial study.

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Limited proteolysis of integrin alpha v beta3 from human placenta. Heterogeneous expression of glucokinase among pancreatic beta cells. Evidence for a proteolytic contaminant in the purified preparation. Increased expression of protooncogenes may be deleterious to cardiac myocytes as indicated by in situ nick-end labeling of DNA fragments. Synthesis of DNA fragments bearing 7,8-dihydro-8-oxo-adenine: a gamma radiation product. We have devised a general, one-step technique for isolation of strains in which the gene coding for an exported protein is fused to the gene for beta-galactosidase (lacZ). A mechanical model interprets palatal thickening as a compensatory response to increased instability of the midpalatal suture effected by an anterior placement of the masseteric muscle mass. Dysphagia is a very common but not universal symptom of the disease process.

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Increasing severity of the attack lead to increasing finding of other radiological changes in the thorax, but these have not yet been statistically examined. Fatal pulmonary hypertension in a patient with mixed connective tissue disease: report of an autopsy case. Bands for IL-5 appeared in all groups, while bands for IL-12 were not detected in any group. In Experiment 1 untreated rats were observed and the temporal structure of their behavior was analyzed to establish an estimate of the false-positive error rate appropriate for use in such analyses. Information is presented on physical and behavioural teratogenic risks, impaired intrauterine growth, and neonatal toxicity, withdrawal, and death. This article describes what to look for and expect from a mentor, how-to be a good protege, and the mentor-protege relationship.

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These results provide a neuroanatomical basis for these receptors jointly playing a role in gastric motor functions. Jurisdictional problems in the autopsy of aircraft accident victims. The degree of conjugate substitution did not affect the liberation rates, whereas enhanced drug activation was observed with decreasing molecular size of the carrier dextran. Development of myeloid and erythroid colonies and proliferation of myeloid stem cells in cyclophosphamide- and erythropoietin-treated mice. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. The minimal inhibitory concentration of amikacin was two- to fourfold lower bisoprolol zebeta 10 mg tablet than the minimal inhibitory concentration of kanamycin for the Salmonella group B, Ps aeruginosa and P multocida strains examined, whereas the E coli and Salmonella group D strains were eqaully susceptible to the 2 antibiotics.

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Number of mast cells in the Harderian gland of the lizard Podarcis sicula sicula (Raf): the annual cycle and its relation to environmental factors and estradiol administration. Changes in free protoporphyrin levels and catalase activity in erythrocytes of rabbits poisoned with lead or phenylhydrazine. Tributyrin specifically induces a lipase with a preference for the sn-2 position of triglyceride in Geotrichum sp. Examples of the application of such techniques to the results of observational epidemiological studies are now proliferating. The ultrastructure of mitotic nuclei of Blastocrithidia triatomae. The role of silent ischemia, reperfusion, or both in the initiation of fatal arrhythmias in larger groups of patients with advanced coronary-artery lesions remains to be defined. Reconstruction of the common bile duct after intra-operative accidental injuries. The uptake of 85Sr in non-fractured bones was reduced which was also most probably due to a decrease of specific activity of 85Sr. Podiatry: a medical care specialty in quest of full professional status and recognition. Localization of enzymes in specialized regions of the microsomal membrane.

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Caesarean delivery is not associated with a significant reduction in long term pelvic floor morbidity compared with spontaneous vaginal delivery. Some aspects of the ecology of the tick, Ixodes ricinus, L., in Wales. Rheumatoid arthritis with systemic manifestations: diagnosis and prognosis. Voltage-dependent properties of electrical synapses formed between identified leech neurones in vitro. There are several different species of RNA synthesized before the cells initiate hemoglobin synthesis. Calcium acetate has been shown in acute studies to have twice the binding capacity of phosphorus per calcium absorbed than calcium carbonate. Introduction of PNO into the lungs of dust-laden rats over a period of 4 months produces an appreciable diminution in the quantity of all the lipid components against the background of an increased lipolytic activity, recuced under the effect of quartz dust. Impaired dentofacial development after radiotherapy of a non-Hodgkin lymphoma: report of case. Kinetics of permeation of 2,3-butanediol on isolated perfused rat kidney model assessed by proton nuclear magnetic resonance spectroscopy. Measuring affect at work: confirmatory analyses of competing mood structures with conceptual linkage to cortical regulatory systems.

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Serological relationships of an iridescent virus (type 25) recently isolated from Tipula sp. Two possible estimators of probabilities of interest have been considered: maximum likelihood and unbiased estimators. Because the guinea pig does not produce AA, it conserves and stores a supply in the aqueous humor via active transport. They try to find out the difference in ways of hurting by perpetrators. These results suggest that patients with systemic sclerosis are not at increased risk for cholelithiasis because of gallbladder dysmotility. Improving task comprehension in the measurement of health state preferences. Ocular anomalies of individuals with mental illness and dual diagnosis. Four patients had dehiscence of a lacerated ureter that had been primarily repaired. When cells were allowed to phagocytose yeast to capacity, endocytosis stopped and subsequent presentation of particles (either yeast or beads) did not result in further uptake.

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The present experiments explore whether there may be some forms of implicit memory for odors. The variable regions isolated from Aa1 and Aa3 Fd fragments not only reacted quantitatively with immunoadsorbents conjugated with the homologous anti-a allotype antibody, but also completely inhibited the binding of the parent Fd fragment to the homologous antibody as fosamax 70mg dosing measured by radioimmune assay. Insulin and glucose requirements during the first stage of labor in insulin-dependent diabetic women. Quantitative determination of Australia (Au-SH) antigen and the clinical course of serum hepatitis. In contrast, virus rescued from the G-variant cDNA clone, in comparison to the clinical isolate and the A-variant, was more fusogenic in vitro but replicated to lower cumulative titers and was less neurovirulent in vivo. A holistic approach to the symptomatology and treatment of poliomyelitis. This region receives primary visceral and gustatory sensory afferent fibers and has widespread interconnections with brainstem structures, hypothalamus, and limbic forebrain.

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A comparative analysis of immunological indices in a local affections of different cortical zones detected that the influence of regulating mechanisms on the cortical level is accompanied by less expressed effects than on the behalf of the hypothalamo-limbic structures. Studies on triple-helical peptides illustrate the ability to observe kinetic folding intermediates directly and the ability to propose detailed mechanisms of folding through the use of real-time NMR methods. Combination effect of photodynamic therapy and microwave hyperthermia on experimental squamous cell carcinoma in vivo. Photocalorimetry allows for a rapid assessment of the rate of polymerization (photospeed) of light-curing dental composites and is ideally suited for the study of kinetics and for optimization of formulations. Effects of starvation for heme on the synthesis of porphyrins in Escherichia coli. The effects of treatment on the lysosomal hydrolases acid phosphatase, cathepsin D, and aryl sulfatase were analyzed at different intervals ranging from 1 to 15 days after seven injections, and from 1 to 48 h after a single injection. Single dose studies carried out in eight healthy volunteers showed that CAPS Phenytoin exhibited a small but significantly higher bioavailability (P less than 0.05). Transfer and induction of delayed hypersensitivity to methylated bovine serum albumin in the absence of adjuvant.

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All 5-HT1A receptor agonists tested dose-dependently decreased the exploratory behaviour of experimentally naive rats, while buspirone (2.5 mg/kg) and gepirone (10 mg/kg) had only a weak effect on the locomotor activity and stereotyped behaviour in the apomorphine-pre-sensitised rats. Patients who underwent mitral valve replacement without preservation of annular-papillary continuity for pure mitral incompetence were classified into rheumatic and myxomatous based on valvular histopathology. The ESR, fibrinogen and plasma viscosity did not correlate with the presence of infection, whereas the CRP level was elevated in the majority of patients with infection/fever and decreased when fever subsided. A kinetic study of the alpha-keto acid dehydrogenase complexes from pig heart mitochondria. The method was developed by Ilizarov for the lengthening of long enchondral bones. Dramatic improvement of severe Pneumocystis carinii pneumonia by corticosteroids despite lack of antipneumocystis therapy in acquired immunodeficiency syndrome. There are two constant-region genes (C beta 1 and C beta 2), each capable of rearrangement and expression as RNA. Auditory Sequential Memory, Verbal Expression, and Auditory Closure.

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The Wisconsin Council on Education (Wiscouncil) developed and pilot tested an evaluation of student performance for Level I fieldwork to be use for both occupational therapy and occupational therapy assistant students. The Limitation of Infarct Size by trimetazidine Trial (LIST) randomized 94 patients with acute myocardial infarction undergoing primary PTCA into two groups: placebo versus trimetazidine i.v. The animal model described could be valuable in studying immunity to parainfluenza virus infections. A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. They had a strong inhibiting activity in a radioimmunoassay test with labeled glycogen. In this contact situation a number of problems were seen to arise, both as a result of circumstances within the sanatorium and because many patients retain health norfloxacin 400 mg uses in bengali -beliefs of a more traditional kind.

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