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Xeloda (Capecitabine)
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Xeloda

Xeloda is a chemotherapy drug. It treats certain types of cancer like breast cancer, colon cancer, and rectal cancer. Xeloda belongs to the group of medicines called antineoplastics.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Biaxin, Leukeran, Naprosyn, Catapres, Avodart, Aricept

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Xeloda are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Hydrocarbon solvent exposure data: compilation and analysis of the literature. Methods of grounded theory were used to explore the questions: How do intensive care nurses perceive touch and the process of touching?. In cases of poor tolerance of the transplant, with repeated rejection, the reduction and eventually the stopping of immunosuppression is necessary. We present a previously undescribed skeletal dysplasia characterized by mild platyspondyly, small thorax with cupping of the anterior ends of the ribs, irregular proximal femoral metaphyses, and lacy appearance of the iliac wings. The tapping test performed at the same time demonstrated that the number of taps was significantly less in the case of ZPC than in the case of ZLP or the placebo. Both the high extensibility of the erythrocyte membrane under shear and its positive heat of deformation represent special features of its elastic response, which are poorly understood as yet. The baboon (Papio ursinus) was used as a model to investigate the possibility of oxalate crystallization in the soft tissues due to long-term feeding of ascorbic acid in high doses. Effect of Intercordin Polfa on coronary blood flow and myocardial oxygen consumption. Mean packed cell volumes and total leukocyte counts were about the same for infected and uninfected animals. The distribution and morphology of LGN K pathway axons within the layers and CO blobs of owl monkey V1.

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These mAbs were also strongly reactive with vascular endothelium within a wide variety of carcinomas (including lung, colon, breast, and others) but not with normal vascular endothelium. Both secretin and caerulein increased the flow rate of pancreatic exocrine secretion. Synthesis and antiviral activities of adamantane spiro compounds. Dietary nonprotein calories and cerebral infarction size in rats. Anatomo-patholocgical study of the pulmonary lesions produced by explosive decompression in the guinea pig. The volume elasticity of the chamber is dependent not only upon the myocardium elastic modulus and the wall thickness ratio, but also on the shape of the chamber. This study involved the use of mathematical statistical procedures following a standard method using SIR database (Scientific Information Retrieval) software implemented on the CDC Cyber 170/730 mainframe in the Trieste University Computing Center that is connected with the Chair of Geriatric Pathology. (e) Like lysozyme, beta-glucuronidase is released from phagocytizing leukocytes. A preliminary study of high resolution P31 nuclear resonance of normal and malignant tissue is reported. Contribution of the Brno University Pharmacy School to the development of pharmaceutical science.

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Radiographic findings and the absence of history of trauma suggest a congenital etiology of this illness. Synthesis of 7-(1,7-disubstituted-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxamido) -cephalosporins. The immediate issues in secondary prevention and the later outcomes in primary prevention are outlined. Substrates studies demonstrate the presence of at least two overlapping PDE species in the major peak(IIs and II). aureus M cells, peptidoglycan particles isolated from the organism were efficiently opsonized by normal human serum and phagocytized by human polymorphonuclear leukocytes.

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Perspectives on postgenome medicine: Gene therapy for brain tumors. Our results show that treatment of EC with HIV-tat induces the cell surface expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1 in a time- and dose-dependent manner. 1-84 PTH stimulated elastase release from PMNL in a dose-dependent and time-dependent manner. Does seasonal reproductive state affect the neuroendocrine response of the ewe to a long-day pattern of melatonin?. In one of the patients with pulmonic valve endocarditis, the pulmonic valve and right ventricular outflow tract revealed the shaggy echoes in diastole, along with systolic fluttering of the pulmonic valve, right ventricular dilatation and paradoxic septal motion. Coronary arterial revascularization in an adult with congenitally corrected transposition. Surgical treatment of hemorrhages of the gastrointestinal system in thrombopenia. This report describes the case of a 60-year-old woman with severe metabolic bone disease and fractures due to vitamin D deficiency and hyperparathyroidism. We conclude with a summary of major unsolved questions in this area.

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Differentiation of chick embryo somites in chorioallantoic culture. Studies on forgiveness have only recently emerged in the psychological literature. Surgical treatment is one option for patients with severe PPH or for symptomatic relief. Several clinical and experimental arguments suggest that the liver has a privileged status regarding allograft rejection. In shaft fractures, however, the anatomical reduction group showed significantly less residual angulation. flaAII (motC, cheV) of Salmonella typhimurium is a structural gene involved in energization and switching of the flagellar motor. As compared to the lymphoblastic and polymorphic types, the follicular cleaved cell lymphoma has less euchromatin, less mitosis, slower growth rate and higher cohesiveness between tumor cells. 175 consecutive patients with a Freestyle aortic bioprosthesis underwent an echocardiographic and Doppler examination according to a common protocol.

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Cutaneous sensory stimulation leading to facial flushing and release of calcitonin gene-related peptide. As the mutations are not limited to the ischemic limb in unilateral patients, they are unlikely to contribute to the pathophysiology of claudication. Molecular species composition of the major phospholipids in brain and retina from rainbow trout (Salmo gairdneri). Learning disability and cerebral palsy are often related to factors present before birth. Research on the function of antagonistic relations of specific proteins from antibodies in immunological reactions. Effects of calcium on iodine metabolism in the light of research with radioactive iodine. We report on a case of thrombus formation on a native bicuspid aortic valve, which was found during an elective operation for aortic valve replacement. An antiseptic mouthrinse containing 0.09 percent zinc chloride as the anticalculus agent provides a clinically relevant reduction in calculus formation in people with a moderate rate of such formation. Thymectomy effectively prevents the development of spontaneous lymphoma in the AKR but how this effect is achieved remains to be determined.

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Three mutations causing alpha-1-antitrypsin deficiency have been identified by gene amplification and direct DNA sequencing. Aspirin-related small bowel diaphragm disease identified during emergency laparotomy. However the effect of polyions is not exclusively related to the electric charge since ineffective molecules were found in both classes of compounds. The particle size of BSA decreased as the PEG-BSA ratio increased. Identification of organic sulfur compounds transferred to fish from petroleum suspension. Thus, Ca channel-dependent mechanism of vasospasm and thrombogenesis induced by PAF in vivo is confirmed. These connections from area TPO to post-Rolandic association areas may have a modulating influence on the sensory association input leading to multimodal areas in the superior temporal sulcus. Sperm or testis-specific variants of H2B observed in sea urchins were not found in the sea star. In addition, the discrepancy between alveolar bone height and the levels of the clinical attachment at cleft sites demonstrated the presence of a long supracrestal connective tissue attachment adjacent to cleft defects.

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Electrophysiologic effects of serotonin on atrioventricular conduction in dogs. The myoepithelial cell, which is ectodermal in origin, plays an essential role in their secretion. Tumor necrosis factor-alpha production induced in T lymphocytes through the AIM/CD69 activation pathway. This action is synergistic and maximal with spermidine, which elevated up to 13-fold the mortality produced by this organophosphorus compound. The pathogenesis of arthritis in Lyme disease: humoral immune responses and the role of intra-articular immune complexes. Effects of sodium selenite on methylmercury embryotoxicity and teratogenicity in mice.

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The purpose of this paper is therefore to attempt to summarize and comment upon present knowledge and belief on this subject. Systematic administration of direct thrombin inhibitors as well as of antithrombin has proven effective at reducing formation of neointima after injury to vessel wall in various animal models. Partial amino acid sequence of a hemocyanin subunit from Palinurus vulgaris. Effects of serum concentration on the expression of carcinogen-induced transformation in the C3H/10T1/2 CL8 cell line. Acanthamoeba discriminates internally between digestible and indigestible particles. A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. Endoscopic sphincterotomy of the lower segment of the sphincter of Oddi resulted in recovery of the normal response to caerulein, i.e. Myelography was performed with a combination of air and an aqueous myelographic contrast media. The ratio of de novo unbalanced translocation to 47, trisomy 21 Down syndrome. Kidney transplantation following total lymphoid irradiation in diabetics.

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Preoperative clinical, hemodynamic and echocardiographic evaluation with operative procedures and early postoperative results of all patients are reported. Minimal requirements for lysis of ectromelia-infected P-815 cells. In contrast, children with other developmental disabilities were notable for general small stature, which affected the hands, feet, eyes, and head size, as well as height. Could bacterial vaginosis be due to the competitive suppression of lactobacilli by aerobic microorganisms?. These psychological variables are conceptualized as maladaptive coping, which may be addressed as part of a biopsychosocial model of treatment for chronic pelvic pain patients. The bioavailability of orally administered testosterone was investigated in normal and hypogonadal men, prepubertal boys, normal women, and in patients with fatty liver, liver cirrhosis and surgical portocaval shunts. This may be brought about through recruitment of sympathetic vasodilatory nervous activity in the central nervous system (CNS). When autoregulation is impaired, blood pressure and hematocrit determine cerebral oxygen delivery.

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Sex chromosome analysis of cartilage cells from the epiphyses of transplanted bones demonstrated that the growing bones rocaltrol were composed of cells from the grafted embryo. Such cardiac performance in Fontan circulation stemmed from increased impedance due to the additional connection of the pulmonary vascular bed to the systemic vasculature and from the lack of a compensatory increase in contractility for increased afterload. Biosynthesis of cell wall peptidoglycan and polysaccharide antigens by protoplasts of type III group B Streptococcus. The oligosynaptic reflex was still elicitable with age, its magnitude decreasing similarly to the monosynaptic reflex. We conducted a prescription survey to examine the use of antianginal drugs in patients with unstable angina in a tertiary care Indian hospital.

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The purified DNA demonstrated excellent biological activity as demonstrated by restriction endonuclease digestion, E. Evaluation of leukergy test as an indicator of infection in hip joint in children. Dimensional measures showed that the delusions of schizophrenics were more unlikely and that those of mood psychotics had a stronger mood theme. Adjuvants and immunostimulants for enhancing vaccine potency in fish. Skin and nail mycoses in patients treated at the Provincial Dermatological Outpatient Clinic in Cracow in the years 1974--1977. Over 14 days neurontin capsules 400mg after recovery from the limbic status, the animals received daily electrical stimulation to the ipsilateral hippocampus at the intensity of afterdischarge threshold which was determined before the injection of QA. Synergism in experimental infections with non-sporulating anaerobic bacteria. We apply this method to images selected from the LLNL/UCSF Digital Mammogram Library, and produce a receiver operating characteristic (ROC) curves to detail the trade-off between probability of detection and false alarms.

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The enzyme activity was significantly decreased in the combination with microsomes obtained from either vitamin D-deficient or vitamin D3-treated rat liver and with SCP obtained from vitamin D3-treated rat. Anti-allergic activities of animal biles and commercially available bile acids were evaluated in experimental allergic disease models. To evaluate the effect of peritoneal fluid (PF) from patients with endometriosis on gamete interaction under hemizona assay (HZA) conditions. Microelectrode experiments showed that the elevation in TEP is due mainly to a depolarization of the basal membrane followed by, and perhaps also accompanied by, a smaller hyperpolarization of the apical membrane. On the other hand, the immunoreactivity of the processes noted at the early stages later on became more intense and covered the full extent of the fibers.

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B-cell chronic lymphocytic leukaemia: clonal chromosome abnormalities and prognosis in 89 cases. In this study, the attachment of uniform salt forms of LPS from Salmonella abortus-equi to erythrocytes from various animal species was investigated. The Rh(e) antigen was eluted as a single component using isoelectric focusing in a pH gradient of 6 to 8. Averaged number of reconstructed intercostal arteries was 2.1 for each patient. Full advantage was taken of the single-strand conformation polymorphism (SSCP) of cDNA and cellular DNA fragments amplified by the polymerase chain reaction (PCR), followed by DNA sequencing of mutated fragments. The significance of the viral carrier state in tissue culture systems. He had chronic renal failure and on hemodialysis (HD) for 22 years. After intradermal skin testing was performed, the erythema and wheal was recorded immediately. National performance on phenergan cough medication an external quality assurance program indicates that analytical techniques used for measurement of tricyclic antidepressants (TCAs) are grossly inadequate. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration.

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Total body irradiation (TBI), given as 10 rad daily for five days a week for a total dose of 150 rad has been used in an attempt to control the chronic phase of chronic myeloid leukemia (CML). Methanol vapour therefore does not appear to exert appreciable toxicity at these exposure levels towards rat lung. False radiologic image of an adrenal tumor due to the large gastric tuberosity. Host stadium specificity in the gregarine assemblage parasitizing Tenebrio molitor. Colorimetric determination of poly(N-vinyl-2-pyrrolidone) in contact lens solutions. The anomalous false-positive results often found in the primed lymphocyte how to give prevacid capsule to a baby typing (PLT) test seem to be partially due to the release of blastogenic factor (BF) from the stimulating cell, resulting in back stimulation of the primed lymphocyte. Buffaloes had lower plasma cortisol and 9-fold higher plasma antidiuretic hormone as compared with the two Holstein groups.

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Late development of vesical fistulas following radiotherapy for carcinoma of the cervix. This effect varied with the age of the spleen donor, but was most dramatic with splenocytes from 2 to 3-week-old mice. A three-part study is described that examines postoperative weakness after open carpal tunnel release and investigates the role of the transverse carpal ligament in the digital flexor pulley system. Most primary lymphedemas occur at the time of puberty with a time span of 10 to 30 years. After exposure to MTX sarcoma 1509a populations generic glucophage xr 1000 mg could not be rescued by the treatment of CF.

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Separation of immunoglobulins by ultracentrifugation in density gradients: application to rubella. 5,888 noninstitutionalized men and women age 65 years or older in four U.S. They have been tested to support the growth of malolactic bacteria in acid medium: only the peptidic fraction supports this growth. The retention of 237Np was followed by whole body counting and serial sacrifice of groups of animals. Dosage distribution in a cross section of broad proton beams of arbitrary configurations. The size of the aryl moiety, the position of the nitrogen relative to the aryl moiety and the type of acyl group are determinants of the carcinogenic potency of N-arylacylhydroxamic acids. Procollagen synthesis in cell culture: nascent chain population consistent with polycistronic mRNA. SV40-transformed cells with temperature-dependent serum requirements. Moreover, we have found that the expressed hMC2R in M3 cells showed similar ACTH binding affinity and coupling to adenylate cyclase as the MC2R of normal human adrenal cells, contrarily to most of the other expression cell models.

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Correlation between what medicine is albendazole microbiology and previous sinus surgery in patients with chronic maxillary sinusitis. Voltage-dependent binding and calcium channel current inhibition by an anti-alpha 1D subunit antibody in rat dorsal root ganglion neurones and guinea-pig myocytes. A novel in situ method of SV40 transfection for the establishment of immortal pulmonary alveolar type II cell lines. When compared to control subjects, baseline serum prolactin levels were elevated in the renal failure patients (range 11 to 16 mmicrogram/ml for renal failure patients, 6 to 9 mmicrogram/ml for controls, P less than 0.05). We examined a family of 15 individuals, seven of whom were affected. Determination of 222Rn emanation fraction and diffusion coefficient in concrete using accumulation chambers and the influence of humidity and radium distribution. The role of insulin resistance in the pathogenesis of diabetes mellitus. There is a lack of evidence that thrombolytic therapy improves clinically relevant outcomes of patients with acute pulmonary embolism. In this article, we review some selected elements of the current state of our theoretical ignorance, focusing mostly on DNA electrophoresis, and we offer several suggestions for further theoretical investigations. Generalized urticaria to cyclophosphamide has been reported previously in 5 cases.

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